Toxicity of cadmium and protective effect of bee honey, vitamins C and B complex

Abstract

The present work aimed to study the toxic effect of cadmium (Cd) on rabbits' blood indices, as well as the therapeutic effect of the antioxidant agents, vitamins C and B complex and bee honey on Cd intoxicated rabbits. Cadmium chloride (CdCl2) was injected subcutaneously at a dose of 3 mg/kg of body weight. The results showed a significant increase in serum glucose, triglycerides, cholesterol, total protein, albumin, globulin, urea and creatinine, compared to the control group. In addition, CdCl2 intoxication increased the levels of uric acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. Concerning haematological parameters, the more obvious changes were an increase in mean corpuscular volume and a decrease in white blood cells count, platelets, lymphocytes, heamatocrit, haemoglobin and red blood cells count. Treatment of CdCl2-intoxicated animals with vitamins C and B complex and bee honey showed a decrease in the harmful effects of Cd by restoring haematological and biochemical changes. Bee honey treatment was the most effective in providing recoveries in the altered blood parameters.

Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism

“…The evidence of the bioactivities of honey can be credited to its polyphenolic contents which, in turn, are regularly linked to its antioxidant and anti-inflammatory actions, as well as to its cardiovascular, antiproliferative and antimicrobial benefits. [22][23][24] A variety of phenolic natural products have been documented for their anti-ulcerogenic activity with an excellent level of stomach protection. In addition to their action as gastroprotective, these antioxidant compounds can be an alternative for the cure of gastric ulcers.…”

Influence of intravenous Egyptian fennel honey infusion on the antioxidant activities and some haemo-indices in healthy goats

“…The leucogram revealed that TWBCs elevated significantly by the 4 th week post intravenous infusion (Fiure 6), where the percentages of lymphocytes ( Figure 7) and monocytes ( Figure 8) increased significantly by the 3 rd week. Ingestion of daily honey solution increased total WBCs, lymphocytes 41,66,69 and monocytes. 41,66,70 In the present study, intravenous honey infusion decreased segmented cells (Figure 9) significantly by the 3 rd week, while increased both band ( Figure 10) and eosinophil cells ( Figure 11) but not significantly.…”

“…In the present work, the leucogram also revealed that TWBCs elevated significantly by the 4 th ( Figure 6), while lymphocytes ( Figure 7), monocytes ( Figure 8) and segmented cells (Figure 9) % showed significant increase earlier by the 3 rd week post infusion. Ingestion of honey solution ameliorates the oxidative stressed toxic effects in rabbits (cadmium) 69 and rats (hydrocarbon 71 or induced malignancy 72 elevating TWBCs and lymphocytes %, rather than in breast cancer women. 73 Also, honey ingestion elevated lymphocytes % in normal healthy human, 74 quails.…”

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

“…Furthermore, the structural changes in the hepatocytes caused by exposure to this metal (Table ) were returned to nearly normal as a result of the impact of honey (Abdel‐Moneim & Ghafeer, ). The research by Abdelaziz et al () has demonstrated that p.o. honey administration (as a fluid, 9 mg/kg bw) to rabbits 1 hour before intoxication with a single dose of CdCl 2 (3 mg/kg bw, s.c.) decreased the activities of enzymatic markers of hepatocellular injury—AST, ALT and ALP, as well as the concentration of bilirubin in the serum compared to rabbits given this xenobiotic alone (Abdelaziz et al, ).…”

“…What is more, its consumption is recommended for people with eye diseases, increased risk of cardiovascular diseases and gastrointestinal disorders (Ajibola et al, 2012). Although, experimental studies confirm the ability of honey to scavenge FR and protect from lipid peroxidation in the liver (Cheng et al, 2015), little is known in the literature about the preventive role of natural honey against Cd action on hepatocytes (Abdelaziz, Elhabiby, & Ashour, 2013;Abdel-Moneim & Ghafeer, 2007).…”