Toxicity of binary mixtures of metal oxide nanoparticles to Nitrosomonas europaea

Yu, Ran; Wu, Junjie; Liu, Meiting; Zhu, Guangcan; Chen, Lianghui; Chang, Yan; Lü, Huijie

doi:10.1016/j.chemosphere.2016.03.065

Cited by 51 publications

(31 citation statements)

References 47 publications

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“…On the other hand, the combination of ZnO Nps with CeO 2 and Y 2 O 3 Nps also increased the toxicity at ≤400 µg/mL and the activation of p-p38 in a clear synergistic effect. The increased cell toxicity observed with CeO 2 Nps in combination with ZnO Nps at a low to moderate concentration, possibly mediated by the activation of p38 in the cells, was also described in the bacterium Nitrosomonas europaea [ 39 ]. The increased toxicity in the bacteria was also independent of the ZnO solubility, a finding that is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

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Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB

Dávila-Grana

Diego-González

González-Fernández

et al. 2018

IJMS

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In recent years, there has been an increase in the production of several types of nanoparticles (Nps) for different purposes. Several studies have been performed to analyse the toxicity induced by some of these individual Nps, but data are scarce on the potential hazards or beneficial effects induced by a range of nanomaterials in the same environment. The purpose of the study described here was to evaluate the toxicological effects induced by in vitro exposure of human cells to ZnO Nps in combination with different concentrations of other metal oxide Nps (Al2O3, CeO2, TiO2 and Y2O3). The results indicate that the presence of these Nps has synergistic or antagonistic effects on the cell death induced by ZnO Nps, with a quite marked beneficial effect observed when high concentrations of Nps were tested. Moreover, analysis by Western blot of the main components of the intracellular activation routes (MAPKs and NFκB) again showed that the presence of other Nps can affect cell activation. In conclusion, the presence of several Nps in the same environment modifies the functional activity of one individual Np. Further studies are required in order to elucidate the effects induced by combinations of nanomaterials.

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Section: Discussionmentioning

confidence: 99%

“…The increased toxicity in the bacteria was also independent of the ZnO solubility, a finding that is consistent with our results. Moreover, the authors characterized the combination of TiO 2 and CeO 2 Nps and identified a protective effect of TiO 2 Nps on the toxicity caused by CeO 2 Nps [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB

Dávila-Grana

Diego-González

González-Fernández

et al. 2018

IJMS

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“…In natural environment, organisms are exposed to a mixture comprising of two or more contaminants, instead of individual ones [ 11 ]. Recently, there are some pioneering studies that highlighted combined toxicity of binary mixtures of CeO 2 and TiO 2 NPs [ 12 ], CuO and ZnO NPs [ 13 ], TiO 2 and ZnO NPs [ 14 ], SiO 2 and TiO 2 NPs [ 15 ]. Most of the studies stated that toxicity of joint action of binary NP mixtures to organisms is antagonistic.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the studies stated that toxicity of joint action of binary NP mixtures to organisms is antagonistic. For example, Yu et al [ 12 ] found that the binary toxicity (antagonistic toxicity) of CeO 2 and TiO 2 NPs to Nitrosomonas europaea was generally lower than that induced by the single NPs. Hua et al [ 16 ] also stated that TiO 2 NPs reduced the effects of ZnO NPs on zebrafish embryos.…”

Section: Introductionmentioning

confidence: 99%

TiO2, SiO2 and ZrO2 Nanoparticles Synergistically Provoke Cellular Oxidative Damage in Freshwater Microalgae

Liu

Wang

et al. 2018

Nanomaterials

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Metal-based nanoparticles (NPs) are the most widely used engineered nanomaterials. The individual toxicities of metal-based NPs have been plentifully studied. However, the mixture toxicity of multiple NP systems (n ≥ 3) remains much less understood. Herein, the toxicity of titanium dioxide (TiO2) nanoparticles (NPs), silicon dioxide (SiO2) NPs and zirconium dioxide (ZrO2) NPs to unicellular freshwater algae Scenedesmus obliquus was investigated individually and in binary and ternary combination. Results show that the ternary combination systems of TiO2, SiO2 and ZrO2 NPs at a mixture concentration of 1 mg/L significantly enhanced mitochondrial membrane potential and intracellular reactive oxygen species level in the algae. Moreover, the ternary NP systems remarkably increased the activity of the antioxidant defense enzymes superoxide dismutase and catalase, together with an increase in lipid peroxidation products and small molecule metabolites. Furthermore, the observation of superficial structures of S. obliquus revealed obvious oxidative damage induced by the ternary mixtures. Taken together, the ternary NP systems exerted more severe oxidative stress in the algae than the individual and the binary NP systems. Thus, our findings highlight the importance of the assessment of the synergistic toxicity of multi-nanomaterial systems.

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“…Hetero-aggregates formed by electrostatic interaction between AgNPs and hematite prevented AgNPs to have a direct contact with Escherichia coli cells [70]. CeO 2 NPs and TiO 2 NPs aggregated when present as a mixture in bacterial culture medium due to their opposite surface charges, while CeO 2 NPs had no effect on ZnONPs stability [71]. Magnetic Fe 3 O 4 NPs with different surface functionalities adsorbed various metal ions (Cr(III), Co(II), Ni(II), Cu(II), Cd(II), Pb(II) and As(III)) by different mechanisms (chelation, ion exchange or/and electrostatic interaction etc.)…”

Section: Transformations Of Mixture Of Enps and Metallic Pollutants Imentioning

confidence: 99%

Effects of Mixtures of Engineered Nanoparticles and Metallic Pollutants on Aquatic Organisms

Liu

Slaveykova

2020

Environments

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In aquatic environment, engineered nanoparticles (ENPs) are present as complex mixtures with other pollutants, such as trace metals, which could result in synergism, additivity or antagonism of their combined effects. Despite the fact that the toxicity and environmental risk of the ENPs have received extensive attention in the recent years, the interactions of ENPs with other pollutants and the consequent effects on aquatic organisms represent an important challenge in (nano)ecotoxicology. The present review provides an overview of the state-of-the-art and critically discusses the existing knowledge on combined effects of mixtures of ENPs and metallic pollutants on aquatic organisms. The specific emphasis is on the adsorption of metallic pollutants on metal-containing ENPs, transformation and bioavailability of ENPs and metallic pollutants in mixtures. Antagonistic, additive and synergistic effects observed in aquatic organisms co-exposed to ENPs and metallic pollutants are discussed in the case of “particle-proof” and “particle-ingestive” organisms. This knowledge is important in developing efficient strategies for sound environmental impact assessment of mixture exposure in complex environments.

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Toxicity of binary mixtures of metal oxide nanoparticles to Nitrosomonas europaea

Cited by 51 publications

References 47 publications

Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB

Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB

TiO2, SiO2 and ZrO2 Nanoparticles Synergistically Provoke Cellular Oxidative Damage in Freshwater Microalgae

Effects of Mixtures of Engineered Nanoparticles and Metallic Pollutants on Aquatic Organisms

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