Toxicity evaluation of Meiliang Bay, Lake Taihu, China—a drinking water source

Chen, Yuangao; Chen, Haigang; Wu, Yulin; Li, Zhaoli; Sun, Liwei; Qu, Mengmeng; Kong, Zhiming

doi:10.1007/s10750-006-0498-0

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…Water quality in west Taihu Lake may have chronic adverse health effects on E. gracilis, suggesting an ecological health risk. Overall, we have found that E. gracilis is a more sensitive ecotoxicological model than human peripheral blood (Wu et al 2008), mouse spermatid cells and zebra fish embryos (Chen et al 2007). …”

Section: Discussionmentioning

confidence: 69%

Organic pollutants and ambient severity for the drinking water source of western Taihu Lake

et al. 2011

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Measurement of the organic compounds found in western Taihu Lake and evaluation of the ambient severity (AS) of the water using multimedia environmental goals (MEG) was conducted. The comet assay and the antioxidant enzyme approach were used to test the potential toxicity of water samples on the microalgae Euglena gracilis. Total concentrations of 25 organic pollutants in samples from two sites were 6.700 and 14.655 μg/l, respectively, with a calculated total ambient severity (TAS) of less than 1 and therefore minimal risk to human and ecological health. Organic extracts from the samples at these two sites was found to induce dose-dependent DNA damage on microalgae cells. DNA damage together with changes in superoxide dismutase (SOD) and peroxidase (POD) activities indicated that the potential pollutant toxicity was far higher at one of the two sites than at the other site. The comet assay combined with the activities of antioxidant enzymes may be of value as a biomarker for presence of organic pollutants in drinking water sources.

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Section: Discussionmentioning

confidence: 69%

Organic pollutants and ambient severity for the drinking water source of western Taihu Lake

et al. 2011

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“…Data are the means ± SD of three replicates. * P \ 0.05 were more than 40 priority pollutants (e.g., pesticides, hydroxybenzenes and heterocyclics) found in the extracts (Chen et al 2007). An increasing number of industrial, agricultural, and commercial organic pollutants in the aquatic environment lead to various deleterious effects on organisms, and in lower concentrations, the organic pollutants may have no detectable acute effects on organisms, but may reduce their survival via long-term chronic effects.…”

Section: Discussionmentioning

confidence: 95%

“…This indicates that the water body of Meiliang Bay, Lake Taihu may have chronic adverse effect on E. gracilis and due to its importance in the ecosystem, the whole system may be in danger. Compared with other kind of assay materials, the microalgae E. gracilis is more sensitive than results with human peripheral blood (Wu et al 2008), mouse spermatid cells (Chen et al 2007) and zebra fish embryos (Chen et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Genotoxicity of organic pollutants in source of drinking water on microalga Euglena gracilis

Zhao

Gao

et al. 2009

Ecotoxicology

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The potential toxicities of organic pollutants in the drinking water source at Meiliang Bay of Lake Taihu were investigated by comet assay and antioxidant enzyme approach on microalgae Euglena gracilis. The organic extracts of the water samples could induce DNA damage on microalgae cells. Statistically significant differences (P < 0.05) were observed at groups of 0.3x, 3x and 10x concentrations compared with the control and a solvent control (DMSO). The organic extracts also affected antioxidant enzyme activity and induced lipid peroxidation in the microalga. In the high dose group, there was an obvious increase in SOD content (P < 0.05). The results suggest that the concentrated organics from water sample extracts have adversary effects on E. gracilis and could possibly damage the ecosystem.

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Gene expression profiles in liver of mouse after chronic exposure to drinking water

Wu¹,

Zhang²,

Zhao³

et al. 2009

J of Applied Toxicology

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cDNA micorarray approach was applied to hepatic transcriptional profile analysis in male mouse (Mus musculus, ICR) to assess the potential health effects of drinking water in Nanjing, China. Mice were treated with continuous exposure to drinking water for 90 days. Hepatic gene expression was analyzed with Affymetrix Mouse Genome 430A 2.0 arrays, and pathway analysis was carried out by Molecule Annotation System 2.0 and KEGG pathway database. A total of 836 genes were found to be significantly altered (1.5-fold, P < or = 0.05), including 294 up-regulated genes and 542 down-regulated genes. According to biological pathway analysis, drinking water exposure resulted in aberration of gene expression and biological pathways linked to xenobiotic metabolism, signal transduction, cell cycle and oxidative stress response. Further, deregulation of several genes associated with carcinogenesis or tumor progression including Ccnd1, Egfr, Map2k3, Mcm2, Orc2l and Smad2 was observed. Although transcription changes in identified genes are unlikely to be used as a sole indicator of adverse health effects, the results of this study could enhance our understanding of early toxic effects of drinking water exposure and support future studies on drinking water safety.

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Toxicity evaluation of Meiliang Bay, Lake Taihu, China—a drinking water source

Cited by 10 publications

References 10 publications

Organic pollutants and ambient severity for the drinking water source of western Taihu Lake

Organic pollutants and ambient severity for the drinking water source of western Taihu Lake

Genotoxicity of organic pollutants in source of drinking water on microalga Euglena gracilis

Gene expression profiles in liver of mouse after chronic exposure to drinking water

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