Toxicity evaluation of biodegradable and thermosensitive PEG‐PCL‐PEG hydrogel as a potential <i>in situ</i> sustained ophthalmic drug delivery system

Yin, Hongbo; Gong, Changyang; Shi, Shuai; Liu, XuYang; Wei, Yuquan; Zhang, Qian

doi:10.1002/jbm.b.31498

Cited by 58 publications

(32 citation statements)

References 26 publications

(40 reference statements)

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“…The injectable PECE hydrogel is thermosensitive nano-material which is flowing sol at low temperature that turns to nonflowing gel at body temperature. Our previous studies have shown its safety to be intracamerally injected as an ideal sustained ophthalmic drug delivery system [14,15]. So, in the current study, we provide data that the antifibrotic effect of bevacizumab loaded PECE hydrogel intracameral injection is superior to bavacizumab alone in the management of postoperative scarring after GFS in the rabbits.…”

Section: Introductionsupporting

confidence: 51%

Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

Han

Wang

et al. 2015

J Mater Sci: Mater Med

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PEG-PCL-PEG (PECE) hydrogel for intracameral injection as a sustained delivery system can get a stable release of the medication and achieve an effective local concentration. The injectable PECE hydrogel is thermosensitive nano-material which is flowing sol at low temperature and can shift to nonflowing gel at body temperature. This study evaluated the intracameral injection of bevacizumab combined with a PECE hydrogel drug release system on postoperative scarring and bleb survival after experimental glaucoma filtration surgery. The best result was achieved in the bevacizumab loaded PECE hydrogels group, which presented the lowest IOP values after surgery. And the blebs were significantly more persistent in this group. Histology, Massion trichrome staining and immunohistochemistry further demonstrated that glaucoma filtration surgery in combination with bevacizumab loaded PECE hydrogel resulted in good bleb survival due to scar formation inhibition. In conclusions, this study demonstrated that bevacizumab-loaded PECE hydrogel for intracameral injection as a sustained delivery system provide a great opportunity to increase the therapeutic efficacy of glaucoma filtration surgery.

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Section: Introductionsupporting

confidence: 51%

Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

Han

Wang

et al. 2015

J Mater Sci: Mater Med

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“…This hydrogel system showed good biodegradability, sustained release, and ocular biocompatibility, indicating that the system is a safe candidate for sustained ophthalmic drug delivery. Many other in situ polymeric gelling systems, such as chitosan, 80 poloxamer, 81 HPMC, 82 PEG-poly-e caprolactone (PCL)-PEG, 83 poly(N-isopropylacrylamide)/chitosan, 84 poloxamer/ chitosan, 85 pluronic F-127/chitosan, 86 and poloxamer/ carbopol 87 were explored for topical ocular applications.…”

Section: Pluronicsmentioning

confidence: 99%

Novel Strategies for Anterior Segment Ocular Drug Delivery

Cholkar

Patel

Vadlapudi

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

147

107

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Research advancements in pharmaceutical sciences have led to the development of new strategies in drug delivery to anterior segment. Designing a new delivery system that can efficiently target the diseased anterior ocular tissue, generate high drug levels, and maintain prolonged and effective concentrations with no or minimal side effects is the major focus of current research. Drug delivery by traditional method of administration via topical dosing is impeded by ocular static and dynamic barriers. Various products have been introduced into the market that prolong drug retention in the precorneal pocket and to improve bioavailability. However, there is a need of a delivery system that can provide controlled release to treat chronic ocular diseases with a reduced dosing frequency without causing any visual disturbances. This review provides an overview of anterior ocular barriers along with strategies to overcome these ocular barriers and deliver therapeutic agents to the affected anterior ocular tissue with a special emphasis on nanotechnology-based drug delivery approaches.

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“…Data indicated that the prepared hydrogel was biocompatible and biodegradable despite the temporary elevated intraocular pressure and slight corneal endothelial damage at specific concentrations. Therefore, this hydrogel showed great biocompatibility, biodegradability, and sustained release property in eyes, making this system a safe candidate for sustained ophthalmic drug delivery [105]. Furthermore, Gong et al [106] studied a PEG-PCL-PEG hydrogel system for basic fibroblastic growth factor (bFGF) antigen delivery.…”

Section: Pharmaceutical Applicationmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

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Toxicity evaluation of biodegradable and thermosensitive PEG‐PCL‐PEG hydrogel as a potential in situ sustained ophthalmic drug delivery system

Cited by 58 publications

References 26 publications

Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

Novel Strategies for Anterior Segment Ocular Drug Delivery

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

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