Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus

Mohamed, Elsnoussi Ali Hussin; Lim, Chung Pin; Ebrika, Omar Saad; Asmawi, Mohd Zaini; Sadikun, Amirin; Yam, Mun Fei

doi:10.1016/j.jep.2010.10.008

Cited by 79 publications

(57 citation statements)

References 26 publications

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“…In addition to bodyweight, relative organ weight has also been used as another basic indicator to determine whether the rats have been exposed to harmful agents [35,36]. Their organs will tend to swell or damage if they were subjected to toxic substances.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

2016

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Background: Oxidative stress (OS) has been linked to the pathology of a variety of chronic and degenerative diseases. Medicinal plants contain bioactive compounds which are capable of preventing and fighting these diseases. The nephroprotective and antioxidant properties of the aqueous leaf extract of Costus afer (C.afer) against cyclosporine A CsA -induced nephrotoxicity in Wistar albino rats were investigated. Methods: Six groups of five weight-matched animals each, were used for the study. The first and second groups served as normal and toxic control and were given olive oil and CsA (50 mg/kg b.w.) orally respectively while groups 3, 4, 5 and 6 ingested 375, 750 and 1125 mg/kg b.w. aqueous leaf extract and 100 mg/kg b.w. of the Silymarin respectively one hour prior to administration of CsA 50 mg/kg b.w. Results: Treatment with C. afer extract at doses of 375, 750 and 1125 mg/kg prevented the CsA induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly (p < 0.05) reduced plasma creatinine, BUN, K + and renal malondialdehyde (MDA). Furthermore, all the doses were able to induce a significant increment (P < 0.05) of renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity, catalase(CAT), glutathione-S-tranferase (GST), serum electrolytes (Na + and HCO 3 − ), body and kidney weight. The nephroprotective effects of C.afer extract were confirmed by a reduced severity of renal cellular damage. Conclusion: Aqueous leaf extract of C.afer has a protective role against CsA-induced nephrotoxicity probably mediated through its antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

2016

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“…given in the volume of 10 mL/kg of body weight (Mohamed et al, 2011). Rats were fasted for 24 h before the administration of CEBP.…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

Antiulcer activity of the chloroform extract ofBauhinia purpurealeaf

Hisam

Zakaria

Mohtarrudin

et al. 2012

Pharmaceutical Biology

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“…Thus there is a need to evaluate the safety and efficacy of these plants thoroughly to maximize their benefits for mankind. 6 Hibiscus rosa-sinensis (Linn.) is an evergreen woody, glabrous, showy shrub 5-8 feet in height belonging to family Malvaceae.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant, Toxicological and wound healing Properties of Hibiscus rosa-sinensis L. (Malvaceae) ethanolic leaves extract on different Experimental animal models

Mondal¹,

Ghosh²,

Sagar³

et al. 2016

IJPER

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Objective: The present research article was conducted to study the toxicity profile, antioxidant potential and wound healing activity of ethanolic leaves extract of Hibiscus rosa-sinensis L. (ELEHR). Materials and Methods: In-vitro antioxidant properties were assessed using DPPH radical scavenging activity, Nitric oxide scavenging activity, and superoxide radical scavenging activity. Acute toxicity was performed to study the general behavioural pattern of mice and sub-acute toxicity studies were performed to study the toxic effects of the test extract on different biochemical and haematological parameters, body and organ weight and histopathology of liver, pancreas and kidney. Wound healing properties was evaluated using excision, incision, dead space and burn wound model. Results: Strong antioxidant activity was recorded in a concentration dependant manner for ELEHR in all three models. The toxicological evaluation of ELEHR revealed that it has a reasonable safety profile as there was no severe alteration. In the evaluation of wound healing properties, ELEHR treated group showed an enhanced wound contraction rate and epithelisation period in both excision and burn wound models, whereas in incision wound model wound breaking strength was significantly increased in extract treated group compared to control. Histology of the skin of healed excised wound also showed restoration to normal architecture in extract treated group. Wound healing activity was further substantiated by enhanced antioxidants and connective tissue markers which were estimated in dead space wound model. Conclusion: Thus ELEHR proved to be effective in wound healing which may be because of strong antioxidant properties and also possesses reasonable safety profile.

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Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus

Cited by 79 publications

References 26 publications

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Antiulcer activity of the chloroform extract ofBauhinia purpurealeaf

Evaluation of Antioxidant, Toxicological and wound healing Properties of Hibiscus rosa-sinensis L. (Malvaceae) ethanolic leaves extract on different Experimental animal models

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