Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos

Quintaneiro, Carla; Teixeira, Bruna; Benedé, Juan L.; Chisvert, Alberto; Soares, Amadeu M.V.M.; Monteiro, Marta S.

doi:10.1016/j.chemosphere.2018.11.096

Cited by 47 publications

(30 citation statements)

References 53 publications

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“…Campos et al [16] confirmed that exposure to OC at 0.23 and 18.23 mg Kg −1 could lead to an increase in GST levels of Chironomus riparius while 4-MBC at 14.13 mg Kg −1 could cause reductions of CAT activity and an increase of GST activity in Chironomus riparius. Quintaneiro et al [17] found that GST activity in zebrafish embryos (0-96 hpf) was elevated after exposure to 4-MBC at above 0.15 mg L −1 . Owing to the complexity of organic UV filters in aquatic environment, the induction of oxidative stress with the significantly affected antioxidant defenses can be used to reflect the comprehensive pollution of PCPs in aquatic environment and to evaluate the environmental risks of polluted water.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Oxidative Stress Status in Zebrafish (Danio rerio) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)

Huang

Wang

et al. 2020

IJERPH

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Organic UV filters are a kind of emerging pollutants, which have been widely used in personal care products (PCPs). This study evaluated the effects of benzophenone-4 (BP-4), 4-aminobenzoic acid (PABA), and 2-phenylbenzimidazole-5-sulfonic acid (PBSA) on the selected indices of antioxidative responses in zebrafish (Danio rerio) liver. Zebrafish were exposed to two different doses (i.e., 0.5 and 5 mg L−1) of semi-static water with three individual compounds. Liver samples were collected on 7 and 14 days to analyze biochemical indicators, including superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH), and malondialdehyde (MDA). Oxidative stress occurred in zebrafish liver with significantly changed indicators during the whole exposure period. Different experimental groups could induce or inhibit the activity of antioxidant enzymes with varying degrees. With a prolonged exposure time and increased exposure dose, the hepatic lipid peroxidation was also obviously observed. Moreover, the toxicity order of three organic UV filters was analyzed using the integrated biomarker response (IBR) index and the results indicate that exposure to PABA for 7 days at 0.5 mg L−1 and PBSA for 7 days at 5 mg L−1 induced the most severe oxidative stress in the liver of zebrafish.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Oxidative Stress Status in Zebrafish (Danio rerio) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)

Huang

Wang

et al. 2020

IJERPH

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“…This issue is of special importance because, as a UV-B filter, OMC can bioaccumulate in the aquatic ecosystems [30,31] and has greater environmental repercussions with potential risks to human health [16,32]. For instance, recently the US state of Hawaii has banned sunscreens containing OMC due the potential risks posed to corals [33].…”

Section: Introductionmentioning

confidence: 99%

UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

Lorigo

Quintaneiro

Lemos

et al. 2019

IJMS

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Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).

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“…Aynı çalışmada, 4-metilbenziliden kafurun hipotalamus-pitüiter-gonadal ve hipotalamustiroid aksında rol oynayan genlerin ekspresyonunu değiştirebileceği bildirilmiştir. 75 Alternatif olarak kullanılan doğal organik kökenli maddelerin de tamamen güvenli olduğu düşünülmemelidir. Örneğin; kollajen üretimini aktive etmek için kozmetiklerde kullanılan soya isoflavonu olan genistein bir fitoöstrojendir ve endokrin bozucu olduğu bilenen bir maddedir, kullanım limitlerine dikkat edilmesi gerekmektedir.…”

Section: Ultraviyole Filtreleriunclassified

Toxicity of Cosmetic Products: Endocrine Disruptor Chemicals

Karaman¹,

Özden²

2019

J Lit Pharm Sci

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Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos

Cited by 47 publications

References 53 publications

Evaluation of the Oxidative Stress Status in Zebrafish (Danio rerio) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)

Evaluation of the Oxidative Stress Status in Zebrafish (Danio rerio) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)

UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

Toxicity of Cosmetic Products: Endocrine Disruptor Chemicals

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