Toxicity, bioaccumulation and biotransformation of Cu oxide nanoparticles in <i>Daphnia magna</i>

Santos-Rasera, Joyce Ribeiro; Neto, Analder Sant’Anna; Monteiro, Regina Teresa Rosim; Gestel, Cornelis A.M. van; Carvalho, Hudson Wallace Pereira de

doi:10.1039/c9en00280d

Cited by 26 publications

(24 citation statements)

References 51 publications

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“…Kwon et al (2015) analyzed the effects of TiO 2 NP and evidenced damage in the morphology of the microvilli membranes of D. magna , and proved that the uptake of such NP depended on their agglomeration. Similar results were found by other authors who considered other kinds of metallic NP such as Au, Ag, and CuO (Asghari et al, 2012; Lovern et al, 2008; Ribeiro et al, 2014; Santos‐Rasera et al, 2019; Seitz et al, 2015) and other microcrustacean species like Ceridaphnia silvestrii (Mansano et al, 2018) and Moina macrocopa (Borase, Patil, et al, 2019). Once the NP reach the filter membranes, the greatest retention is generally in the intestine, affecting growth and inducing individuals' mortality (Khan et al, 2014; Kwon et al, 2014; Zhao & Wang, 2012; Zhu et al, 2010).…”

Section: Main Ecotoxicological Effects Of Np On Microcrustaceanssupporting

confidence: 85%

Metallic, metal oxide, and metalloid nanoparticles toxic effects on freshwater microcrustaceans: An update and basis for the use of new test species

Gutiérrez

Ale

Andrade

et al. 2021

Water Environment Research

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In this article, we performed a literature review on the metallic, metal oxide, and metalloid nanoparticles (NP) effects on freshwater microcrustaceans, specifically focusing on (i) the main factors influencing the NP toxicity and (ii) their main ecotoxicological effects. Also, given that most studies are currently developed on the standard test species Daphnia magna Straus, we analyzed (iii) the potential differences in the biological responses between D. magna and other freshwater microcrustacean, and (iv) the ecological implications of considering only D. magna as surrogate of other microcrustaceans. We found that NP effects on microcrustaceans depended on their intrinsic properties as well as the exposure conditions. Among the general responses to different NP, we identified body burial, feeding inhibition, biochemical effects, metabolic changes, and reproductive and behavioral alterations. The differences in the biological responses between D. magna and other freshwater microcrustacean rely on the morphology (size and shape), ecological traits (feeding mechanisms, life cycles), and intrinsic sensitivities. Thus, we strongly recommend the use of microcrustaceans species with different morphological, physiological, and ecological characteristics in future ecotoxicity tests with NP to provide relevant information with regulation purposes regarding the discharge of NP into aquatic environments. Practitioner points Nanoparticles effects depend on intrinsic and external factors. Nanoparticles affect the morphology, physiology, and behavior. Effects on Daphnia differ from other microcrustaceans. The use of more diverse test species is suggested.

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Section: Main Ecotoxicological Effects Of Np On Microcrustaceanssupporting

confidence: 85%

Metallic, metal oxide, and metalloid nanoparticles toxic effects on freshwater microcrustaceans: An update and basis for the use of new test species

Gutiérrez

Ale

Andrade

et al. 2021

Water Environment Research

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“…When NPs are used in biomedical applications two very important characteristics must be considered: toxicity and cellular uptake (Rees et al, 2019;Santos-Rasera et al, 2019;Zhang C. et al, 2019). In fact, the biocompatibility of NPs is one of the most critical characteristics of nanoplatforms to be suitable for biomedical purposes (Elmowafy et al, 2019;Liu et al, 2020), and the NPs capability to be internalized by target cells, compared to not-target cells, is a very important goal (Emami et al, 2019;Khan et al, 2019;Khanna et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Sanità

Carrese

Lamberti

2020

Front. Mol. Biosci.

341

147

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The use of nanoparticles (NP) in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the uptake efficiency significantly limit their use in clinical practice. The physico-chemical properties of NPs including surface composition, superficial charge, size and shape are considered the key factors that affect the biocompatibility and uptake efficiency of these nanoplatforms. Thanks to the possibility of modifying physico-chemical properties of NPs, it is possible to improve their biocompatibility and uptake efficiency through the functionalization of the NP surface. In this review, we summarize some of the most recent studies in which NP surface modification enhances biocompatibility and uptake. Furthermore, the most used techniques used to assess biocompatibility and uptake are also reported.

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“…A detailed overview is given in Supporting Information, Tables S1 and S2. In brief, dose-response relationship data on D. magna immobilization were retrieved from 20 reports: Briffa et al (2018), Cui et al (2017), Cupi et al (2016), Dabrunz et al (2011), Heinlaan et al (2008), Kim et al (2017), Lee et al (2012), Ma et al (2012), Newton et al (2013), Oleszczuk et al (2015), Santos-Rasera et al (2019), Schiwy et al (2016), Seo et al (2014), Song et al (2015), Sovová et al (2009), Strigul et al (2009), Wyrwoll et al (2016), Xiao et al (2015Xiao et al ( , 2016, and Yang et al (2014). The detailed information of each record of ENM, like size and coating, test duration, illumination, and media composition is listed in Supporting Information, Tables S1 and S2.…”

Section: Data Selection and Collectionmentioning

confidence: 99%

Development of a Quasi–Quantitative Structure–Activity Relationship Model for Prediction of the Immobilization Response of Daphnia magna Exposed to Metal‐Based Nanomaterials

Bunmahotama

Vijver

Peijnenburg

2022

Enviro Toxic and Chemistry

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The conventional Hill equation model is suitable to fit dose-response data obtained from performing (eco)toxicity assays. Models based on quasi-quantitative structure-activity relationships (QSARs) to estimate the Hill coefficient ( ) n H were developed with the aim of predicting the response of the invertebrate species Daphnia magna to exposure to metal-based nanomaterials. Descriptors representing the pristine properties of nanoparticles and media conditions were coded to a quasi-simplified molecular input line entry system and correlated to experimentally derived values of n H . Monte Carlo optimization was used to model the set of n H values, and the model was trained on the basis of reported dose-response relationships of 60 data sets (n = 367 individual response observations) of 11 metal-based nanomaterials as obtained from 20 literature reports. The model simulates the training data well, with only 2.3% deviation between experimental and modeled response data. The technique was employed to predict the dose-response relationships of 15 additional data sets (n = 72 individual observations) not included in model development of seven metal-based nanomaterials from 10 literature reports, with an average error of 3.5%. Combining the model output with either the median effective concentration value or any other known effect level as obtained from experimental data allows the prediction of full dose-response curves of D. magna immobilization. This model is an accurate screening tool that allows the determination of the shape and slope of dose-response curves, thereby greatly reducing experimental effort in case of novel advanced metal-based nanomaterials or the prediction of responses in altered exposure media. This screening model is compliant with the 3Rs (replacement, reduction, and refinement) principle, which is embraced by the scientific and regulatory communities dealing with nanosafety.

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Toxicity, bioaccumulation and biotransformation of Cu oxide nanoparticles in Daphnia magna

Abstract: This study investigated the toxicity, bioaccumulation and biotransformation of copper oxide nanoparticles (nCuO) and CuSO4 in Daphnia magna.

Cited by 26 publications

References 51 publications

Metallic, metal oxide, and metalloid nanoparticles toxic effects on freshwater microcrustaceans: An update and basis for the use of new test species

Metallic, metal oxide, and metalloid nanoparticles toxic effects on freshwater microcrustaceans: An update and basis for the use of new test species

Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Development of a Quasi–Quantitative Structure–Activity Relationship Model for Prediction of the Immobilization Response of Daphnia magna Exposed to Metal‐Based Nanomaterials

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