Toxicity assessment of the green Dunaliella salina microalgae

El-Baz, Farouk; Aly, Hanan F.; Salama, Abeer

doi:10.1016/j.toxrep.2019.08.003

Cited by 19 publications

(13 citation statements)

References 19 publications

(20 reference statements)

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“…These results are in line with a previous study that showed that pretreatment with D. salina microalga (1000 mg/kg) normalized liver enzyme levels in rats intoxicated with paracetamol [40]. D. salina has also been shown to be safe [41] and exert a hepatoprotective action in carbon tetrachloride-induced liver toxicity via the presence of many forms of carotene and xanthophylls [42].…”

Section: Discussionsupporting

confidence: 90%

Dunaliella salina microalgae oppose thioacetamide-induced hepatic fibrosis in rats

2020

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HighlightsDunaliella salina opposed the fibrotic effect of thioacetamide in rat liver.D. salina significantly reduced serum levels of ALT, AST, ALP and total bilirubin.D. salina revealed an elevation in GSH and a reduction in MDA in sera.D. salina caused fall in hepatic contents of α-SMA and collagen I to normal level.Scoring of fibrosis indicated that D. salina is an efficient hepatoprotective agent.

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Section: Discussionsupporting

confidence: 90%

Dunaliella salina microalgae oppose thioacetamide-induced hepatic fibrosis in rats

2020

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“…The third and fourth groups were administered D. salina (100 and 200 mg/kg; p.o. ), respectively [26,27], after TAA injection for 7 days.…”

Section: Methodsmentioning

confidence: 99%

Amelioration of Hepatic Encephalopathy Using Dunaliella salina Microalgae in Rats: Modulation of Hyperammonemia/TLR4

Baz

Elgohary

Salama

2021

BioMed Research International

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Hepatic encephalopathy (HE) is a neuropsychiatric disease that is developed as a complication of both acute and chronic liver failure affecting psychomotor dysfunction, memory, and concentration. This study is aimed at evaluating the therapeutic effects of Dunaliella salina (D. salina) microalgae in thioacetamide- (TAA-) induced HE in rats. HE was induced by TAA (200 mg/kg; i.p.) for three successive days. Forty male Wister albino rats were divided into 4 groups; the first group was served as a normal, and the second group was injected with TAA and served as TAA control. The third and fourth groups were administered D. salina (100 and 200 mg/kg; p.o.), respectively, after TAA injection for 7 days. The behavioral and biochemical markers as well as histological aspects of HE were estimated. This study revealed that TAA caused behavioral changes, oxidative stress, neuroinflammation, nuclear pyknosis, and neurons degeneration. D. salina improved liver function and decreased oxidative stress and inflammatory mediator as TLR4 protein expression. Also, D. salina elevated HSP-25 and IGF-1 as well as improved brain histopathological alterations. In conclusion, D. salina exerted a therapeutic potential against HE via its antioxidant, antiinflammatory and cytoprotective effects.

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“…[18] for 30 days. Groups 4 and 5: diabetic rats received D. salina powder (100 & 200 mg/kg) [19,20] for 30 days.…”

Section: Methodsmentioning

confidence: 99%

Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin

El-Baz

Salama

2020

BioMed Research International

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Diabetic neuropathy (DN) is a widespread disabling disorder including peripheral nerves’ damage. The aim of the current study was to estimate the potential ameliorative effect of Dunaliella salina (D. salina) on DN and the involvement of the thioredoxin. Diabetes was induced by streptozotocin (STZ; 50 mg/kg; i.p). Glimepiride (0.5 mg/kg) or D. salina powder (100 or 200 mg/kg) were given orally, after 2 days of STZ injection for 4 weeks. Glucose, total antioxidant capacity (TAC), superoxide dismutase (SOD), and catalase (CAT) serum levels as well as brain contents of thioredoxin (Trx), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured with the histopathological study. STZ-induced DN resulted in a significant (P<0.05) rise in glucose blood level and brain contents of TNF-α and IL-6 and produced a reduction in serum TAC, SOD, CAT, and brain Trx levels with irregular islets of Langerhans cells and loss of brain Purkinje cells. Treatment with glimepiride or both doses of D. salina alleviated these biochemical and histological parameters as compared to the STZ group. D. salina has a neurotherapeutic effect against DN via its inhibitory effect on inflammatory mediators and oxidative stress molecules with its upregulation of Trx activity.

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Toxicity assessment of the green Dunaliella salina microalgae

Abstract: Graphical abstract

Cited by 19 publications

References 19 publications

Dunaliella salina microalgae oppose thioacetamide-induced hepatic fibrosis in rats

Dunaliella salina microalgae oppose thioacetamide-induced hepatic fibrosis in rats

Amelioration of Hepatic Encephalopathy Using Dunaliella salina Microalgae in Rats: Modulation of Hyperammonemia/TLR4

Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin

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