Toxicity assessment of nanoparticles in various systems and organs

Yang, Yuan; Qin, Z. H.; Zeng, Wei; Yang, Tao; Cao, Yubin; Mei, Chaorong; Yu, Keming

doi:10.1515/nano.0034.00115

Cited by 33 publications

(49 citation statements)

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“…Some recent studies predicted that most of the currently produced TiO 2 will be converted into nano forms by the end of year 2026 (Galletti, 2016). Moreover, TiO 2 NPs are among the most nanomaterials used in therapy, drug delivery, engineering, agriculture, personal care products, cosmetics, sunscreens, toothpaste, electronics, clothes, paints, and covers, as imaging agent and foodstuffs (Chabanyuk, 2014;Galletti;Yang et al, 2017). In addition, TiO 2 NPs are widely invested in nanomedicine and are being used in diseases diagnosis and advanced imaging and nanotherapeutics like photodynamic therapy, antimicrobial drugs and skin care products (Yuan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles

Al‐Doaiss

Ali

et al. 2019

Int. J. Morphol.

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Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate the renal damage that might be induced by the acute toxicity TiO 2 NPs. A total of 40 healthy male adult Wistar albino rats (Rattus norvegicus) were exposed to TiO 2 NPs (126, 252, 378 mg/kg bw) for 24 and 48 h. Fresh portions of the kidneys from each rat were processed for histological and histochemical alterations. In comparison with respective control rats, exposure to TiO 2 NPs has marked the following glomerular, tubular and interstitial alterations including the followings: glomerular congestion, Bowman's capsule swelling and dilatation, inflamed glomeruli, renal tubules cloudy swelling, karyorrhexis, karyolysis, infiltration of inflammatory cells, congestion, necrosis, hydropic degeneration, dilatation and congestion of blood vessels, hyaline droplets and hyaline casts precipitation, interstitial edema and fibrosis. From the findings of the current work one may conclude that TiO 2 NPs are capable of inducing kidney damage with more insulation in the cortex and the proximal convoluted tubules than the medulla and the distal ones respectively. In addition, it might be concluded that renal damage induced by these nanomaterials is dose and duration of exposure dependent. Further hematological, biochemical, immunohistochemical, and ultra-structural studies are recommended.

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Section: Introductionmentioning

confidence: 99%

Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles

Al‐Doaiss

Ali

et al. 2019

Int. J. Morphol.

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“…They have smaller size, large number of atoms on their surface and different surface characteristics, as level of energy. These differences attract more attentions to study adverse effects of nanoparticles (Shi et al, 2013 andYang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The Possible Protective Role of N-Acetyl Cysteine against Titanium Dioxide Nanoparticles Intestinal Toxicity in Adult Male Albino Rats

Amin

Shabana

2019

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: With extensive applications of nanoparticles including titanium dioxide nanoparticles (TiO2 NPs) in different fields, many adverse effects may threat both environmental and medical health. Aim of this work: To evaluate the role of n-acetyl cysteine (NAC) against TiO2 NPs intestinal toxicity in adult albino rats. Material and methods: Fifty adult male albino rats were classified into five groups. Group I: negative control received regular diet and water. Group II: positive control administered 1ml of 5% gum acacia solution once a day. Group III: gavaged orally with NAC (100 mg/kg). Group IV: orally gavaged with TiO2 NPs (1200 mg/kg) once a day. Group V: orally gavaged once daily with TiO2 NPs (1200 mg/kg) and NAC (100 mg/kg). After 6 weeks, all rats were weighed and blood sample were submitted to estimate serum level of citrulline. Then parts of ileum from all rats was dissected and subjected to interleukin 6 (IL6), interleukin 10 (IL10) and tumor necrosis factor (TNF-α) estimation, histopathological examination and determine the extent of DNA damage by gel electrophoresis. Results: The results revealed that TiO2 NPs induced significant decreases in body weight, and serum level of citrulline with significant increases in IL6, TNF-α and significant decrease IL10 in tissues of ileum. These were associated with histopathological changes in the ileum and DNA damage detected by gel electrophoresis. Co-administration of NAC with TiO2 NPs provided protection against these changes. Conclusion: TiO2 NPs exposure causes inflammation in ileum with DNA damage and administration of NAC offers protection against its damaging effects.

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“…NPs, with smaller diameters and larger surface areas, are suspended for longer in the air and result in more harm to the public 5,6 . A large number of studies have found that widespread exposure to NPs is nocuous to the main organs of humans, such as the respiratory tract, skin, brain, lungs, and immune system [7][8][9][10] , leading to neuroinflammation and decreased cognitive abilities, even causing a DNA damage [11][12][13][14][15] . According to an analysis of the Global Burden of Disease Study 2017 (ref.…”

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confidence: 99%

High-performance particulate matter including nanoscale particle removal by a self-powered air filter

et al. 2020

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Particulate matter (PM) pollutants, including nanoscale particles (NPs), have been considered serious threats to public health. In this work, a self-powered air filter that can be used in high-efficiency removal of PM, including NPs, is presented. An ionic liquid-polymer (ILP) composite is irregularly distributed onto a sponge network to form an ILP@MF filter. Enabled by its unique electrochemical properties, the ILP@MF filter can remove PM 2.5 and PM 10 with high efficiencies of 99.59% and 99.75%, respectively, after applying a low voltage. More importantly, the charged ILP@MF filter realizes a superior removal for NPs with an efficiency of 93.77%. A micro-button lithium cell or silicon-based solar panel is employed as a power supply platform to fabricate a portable and self-powered face mask, which exhibits excellent efficacy in particulate removal compared to commercial masks. This work shows a great promise for high-performance purification devices and facile mask production to remove particulate pollutants.

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Toxicity assessment of nanoparticles in various systems and organs

Cited by 33 publications

References 0 publications

Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles

Renal Histological Alterations Induced by Acute Exposure of Titanium Dioxide Nanoparticles

The Possible Protective Role of N-Acetyl Cysteine against Titanium Dioxide Nanoparticles Intestinal Toxicity in Adult Male Albino Rats

High-performance particulate matter including nanoscale particle removal by a self-powered air filter

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