Toxicity and tissue distribution of methylsulfonylmethane following oral gavage in broilers

Rasheed, M.S. Abdul; Oelschlager, Maci L.; Smith, Brooke N; Bauer, Laura L.; Whelan, Rose; Dilger, Ryan N.

doi:10.3382/ps/pez265

Cited by 10 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…bacterial inhibition by MSM were available for comparison. However, one study was published investigating toxicity and tissue distribution of MSM following oral gavage in broilers (Rasheed et al 2019). Study one used a single oral dose of MSM at 0, 50, 100, 300, 1000 or 2,000 mg kg À1 body weight.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study in poultry showed a single oral dose MSM at 1000–2000 or 1500 mg kg −1 BW for 21 days did not show any adverse health effects in the chickens, nor did MSM provide growth enhancement over unmedicated controls (Rasheed et al . ). No antibacterial studies of MSM were found in the literature.…”

Section: Introductionmentioning

confidence: 97%

“…It has been given Generally Regarded as Safe status by the United States Food and Drug Administration (FDA) and is classified as a nutritional supplement for horses, dogs and humans (Butawan et al 2017). A recent study in poultry showed a single oral dose MSM at 1000-2000 or 1500 mg kg À1 BW for 21 days did not show any adverse health effects in the chickens, nor did MSM provide growth enhancement over unmedicated controls (Rasheed et al 2019). No antibacterial studies of MSM were found in the literature.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Methylsulfonylmethane exhibits bacteriostatic inhibition of Escherichia coli , and Salmonella enterica Kinshasa, in vitro

Poole

Benjamin²,

Genovese

et al. 2019

J Appl Microbiol

View full text Add to dashboard Cite

Aims To evaluate antibacterial properties of methylsulfonylmethane (MSM) on Escherichia coli (MDRE21) and Salmonella enterica serovar Kinshasa (SK132). Methods and Results Bacterial proliferation analysis was measured spectrophotometrically during log phase growth with 0, 3, 5, 7, 10, 12 and 16% MSM. To assess the mechanism of inhibition, cultures were grown overnight with 0–16% MSM and enumerated on unmedicated brain–heart infusion agar (BHIA) or BHIA with 0–16% MSM. The long‐term viability studies were done to evaluate the impact of 10% MSM. Absorbance data indicated a dose‐dependent inhibition from 0 to 16% MSM. There was no growth of MDRE21 or SK132 on BHIA in 10–16% MSM. Both strains enumerated on unmedicated BHIA from overnight cultures with 10–16% MSM were able to partially recover. Conclusions Recovery after MSM removal may be indicative of a bacteriostatic mechanism of inhibition. The long‐term viability studies illustrated that neither MDRE21 nor SK132 could be rescued from 10% MSM after 5 or 6 days respectively. Significance and Impact of the Study Methylsulfonylmethane antibacterial activity may prove useful during pre or postharvest food safety as a disinfectant. The primary benefit being, its clinical safety to humans. Comparisons to other disinfectants would also need to be done to determine if MSM was superior to those already on the market and would be cost effective.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Methylsulfonylmethane exhibits bacteriostatic inhibition of Escherichia coli , and Salmonella enterica Kinshasa, in vitro

Poole

Benjamin²,

Genovese

et al. 2019

J Appl Microbiol

View full text Add to dashboard Cite

show abstract

“…Thus, the rise in serine and threonine might be beneficial for broiler physiology. The increase in dimethyl sulphonealso known as methyl sulphonyl methane and commonly deriving from the dietary constituents and microbiota metabolism (Engelke et al 2005)can improve chicken health (Jiao et al 2017;Abdul Rasheed et al 2019) due to its antioxidant and antiinflammatory effects (Marañ on et al 2008). The reduction in ascorbate, which is a renowned antioxidant compound endogenously synthetised by the avian kidney (Grollman and Lehninger 1957), can be interpreted as a consequence of the antioxidant and radical scavenging properties of tannins (Chung et al 1998;Redondo et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Insights into the mode of action of tannin-based feed additives in broiler chickens: looking for connections with the plasma metabolome and caecal microbiota

Brugaletta

Luise

Cesare

et al. 2020

Italian Journal of Animal Science

View full text Add to dashboard Cite

“…As MSM is absorbed via the small intestine of animals, MSM-enriched animal products (e.g., milk) have been reported [16]. Earlier studies also reported that dietary MSM could enrich its concentration in the plasma, brains, and livers of broiler chickens [17,18], suggesting the possibility of effective transfer of dietary MSM into animal products. However, there are scarce data about the incorporation of dietary MSM into the eggs of laying hens, which prompted us to set up the current experiment.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Dietary Methyl Sulfonyl Methane into the Egg Albumens of Laying Hens

et al. 2022

View full text Add to dashboard Cite

This study evaluated the effects of graded levels of dietary methyl sulfonyl methane (MSM) on the laying performance, egg quality, antioxidant capacity, and the incorporation of MSM into the egg albumen of laying hens. A total of 240 73-week-old laying hens (Lohmann Brown Lite) were randomly allotted to 1 of 5 dietary treatments, with 8 replicates of 6 birds per replicate. The experimental diets were formulated by mixing corn and soybean meal-based diets with MSM to reach 0.0, 1.0, 2.0, 3.0, and 4.0 g per kg of diet, and were fed to the birds for 12 weeks. Increasing dietary MSM led to a significant quadratic effect on the feed intake and feed conversion ratio at 4 weeks (p < 0.05). However, none of the egg qualities and egg components were altered by dietary MSM. The deposition of MSM in egg albumens increased in a linear manner (p < 0.05) in response to the increasing dietary MSM levels. The concentration of malondialdehyde in the egg yolk decreased at 12 weeks (linear and quadratic effect; p < 0.05), as the dietary MSM levels increased. Increasing dietary MSM affected the indicators of antioxidant/oxidative stress in the serum samples, such as superoxide dismutase at 12 weeks (linear and quadratic effect; p < 0.05), total antioxidant capacity at 8 and 12 weeks (linear effect; p < 0.05), and malondialdehyde at 8 weeks (linear effect; p < 0.05). Taken together, our study shows that dietary MSM has potential to be used as an antioxidant feed additive for laying hens, and can be used to produce functional eggs with health benefits for humans.

show abstract

Toxicity and tissue distribution of methylsulfonylmethane following oral gavage in broilers

Cited by 10 publications

References 22 publications

Methylsulfonylmethane exhibits bacteriostatic inhibition of Escherichia coli , and Salmonella enterica Kinshasa, in vitro

Methylsulfonylmethane exhibits bacteriostatic inhibition of Escherichia coli , and Salmonella enterica Kinshasa, in vitro

Insights into the mode of action of tannin-based feed additives in broiler chickens: looking for connections with the plasma metabolome and caecal microbiota

Incorporation of Dietary Methyl Sulfonyl Methane into the Egg Albumens of Laying Hens

Contact Info

Product

Resources

About