Toxicity and genotoxicity evaluation of Passiflora alata Curtis (Passifloraceae)

Boeira, Jane Marlei; Fenner, Raquel; Betti, Andresa Heemann; Provensi, Gustavo; Lacerda, Luciana de Almeida; Barbosa, Patrícia Rick; González, Félix Hilario Díaz; Corrêa, Ana Grasielle Dionísio; Driemeier, David; Dall’Alba, Marília P.; Pedroso, Annelise P.; Gosmann, Grace; Silva, Juliana da; Rates, Stela Maris Kuze

doi:10.1016/j.jep.2009.09.037

Cited by 21 publications

(15 citation statements)

References 32 publications

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“…of Passiflora alata aqueous extract containing 2.6% of flavonoids (PA) did not alter behavioral, histopathological, biochemical and hematological parameters in rats, indicating low acute toxicity (Boeira et al, 2010). This is in line with the study by Amaral et al (2001) reporting that an aqueous extract administrated daily (800 mg/kg, p.o.)…”

Section: Introductionsupporting

confidence: 83%

“…The hypothesis that PA acts on CYP450 isoforms deserves further studies. Our interest in studying the effect of Passiflora alata on weight gain and feeding behavior was based on a previous report by Boeira et al (2010) that demonstrated that rats repeatedly treated (14 days) with PA 300 mg/kg (p.o.) did not gain weight.…”

Section: Groupmentioning

confidence: 99%

“…to pregnant rats did not affect the fertility neither caused offspring alterations. However, PA presented genotoxic effect assessed by the comet and micronucleus assays in mice blood cells (Boeira et al, 2010). Moreover, rats treated for 14 days with this extract at 300 mg/kg (p.o.)…”

Section: Introductionmentioning

confidence: 98%

“…Moreover, rats treated for 14 days with this extract at 300 mg/kg (p.o.) did not gain weight, showed irritability signs and had tendency to anxiogenic-like behavior in the elevated plus maze test (Boeira et al, 2010;Gosmann et al, 2011). These results could be indicative of toxicity or, alternatively, suggest a specific effect on feeding and anxious behavior, as described for endogenous ligand of central-type benzodiazepines receptors such as endozepines (De Mateos-Verchere et al, 1998Do Rego et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Repeated administration of an aqueous spray-dried extract of the leaves of Passiflora alata Curtis (Passifloraceae) inhibits body weight gain without altering mice behavior

Braga

Stein

Stolz

et al. 2013

Journal of Ethnopharmacology

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Section: Introductionsupporting

confidence: 83%

Section: Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Repeated administration of an aqueous spray-dried extract of the leaves of Passiflora alata Curtis (Passifloraceae) inhibits body weight gain without altering mice behavior

Braga

Stein

Stolz

et al. 2013

Journal of Ethnopharmacology

Self Cite

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“…N/O: no observation, F: female, M: male, n: number of organisms. (2014), who reported no negative effects from P. incarnata in pregnant and lactating rats, and Devaki et al (2012) who reported that P. incarnata does not produce toxic effects in rats; however, Boeira et al (2010) reported that P. alata produces mild genotoxic damage and inhibits weight gain in mice. The GSI and PDGMS of the females in P2 and P3 treatments showed statistically significant differences with respect to those obtained from the NAT females.…”

Section: Discussionmentioning

confidence: 99%

Effect of Passiflora incarnata (L) extract on gonadal maturation in young tilapia (Oreochromis sp.)

Ramirez

López-Cardiel

Lezama

et al. 2017

lajar

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ABSTRACT. The effect of Passiflora incarnata's extract (PE) on gonadal maturation in young tilapia (Oreochromis sp.) was evaluated by administering feed supplemented with PE during the first 90 days immediately after yolk sac assimilation. One hundred and fifty fishes with 0.01 ± 0.003 g average body weight were randomly distributed in ten tanks with the following duplicated treatments: commercial feed (NAT), NAT with 60 mg kg -1 of 17-MT (MET), and NAT supplemented with 31.10 mg, 62.30 mg and 124.60 mg of PE g -1 (P1, P2, P3 respectively). There were no significant differences (P > 0.05) in the average body weight or in the male-female sex ratio between the experimental treatments (P1, P2, P3) and the control (NAT). Statistical differences in the gonadosomatic index (GSI) and the percentage distribution of gonadal maturation stages (PDGMS) were observed in females of P2 and P3. With respect to the females of NAT, the treatments P2 and P3 presented a lower GSI and a lower percentage of females in stage III (GSI: 1.11 ± 0.88, 1.04 ± 0.99 and 1.71 ± 0.72; PDGMS: 45, 30 and 80%, respectively). No significant differences in GSI or PDGMS were observed in the males. The results suggest that the observed differences in GSI and PDGMS in females are unrelated to antinutritional effects. Instead, these differences could be due to a possible antiestrogenic effect attributed to the possible anti-aromatase action of some of its compounds. Future research focusing on the use of PE for reproductive control in tilapia is suggested.

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Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

Konta

Almeida

Amaral

et al. 2013

Phytotherapy Research

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Various species of the genus Passiflora have been extensively used in traditional medicine as sedatives, anxiolytics, diuretics and analgesics. In the present study, after the identification and quantification of phytochemical compounds from yellow passion fruit pulp by liquid chromatography-photodiode array-mass spectrometry (HPLC-PDA-MS/MS), its antihypertensive effect was investigated on spontaneously hypertensive rats. Additionally, the renal function, evaluated by kidney/body weight, serum creatinine, proteinuria, urinary flow, reduced glutathione (GSH) levels and thiobarbituric acid-reactive substances (TBARS) and mutagenicity in bone marrow cells were assessed to evaluate the safety of passion fruit consumption. Yellow passion fruit pulp (5, 6 or 8 g/kg b.w.) was administered by gavage once a day for 5 consecutive days. HLPC-PDA-MS/MS analysis revealed that yellow passion fruit pulp contains phenolic compounds, ascorbic acid, carotenoids and flavonoids. The highest dose of passion fruit pulp significantly reduced the systolic blood pressure, increased the GSH levels and decreased TBARS. There were no changes in renal function parameters or the frequency of micronuclei in bone marrow cells. In conclusion, the antihypertensive effect of yellow passion fruit pulp, at least in part, might be due to the enhancement of the antioxidant status. The exact mechanisms responsible by this effect need further investigation.

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Toxicity and genotoxicity evaluation of Passiflora alata Curtis (Passifloraceae)

Cited by 21 publications

References 32 publications

Repeated administration of an aqueous spray-dried extract of the leaves of Passiflora alata Curtis (Passifloraceae) inhibits body weight gain without altering mice behavior

Repeated administration of an aqueous spray-dried extract of the leaves of Passiflora alata Curtis (Passifloraceae) inhibits body weight gain without altering mice behavior

Effect of Passiflora incarnata (L) extract on gonadal maturation in young tilapia (Oreochromis sp.)

Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

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