Toxicity and antioxidant activity of Syzygium aromaticum, Mondia whitei, Carissa spinarum and Caesalpinia bonduc

Afanyibo, YG; Esseh, K; Idoh, Kokou; Koudouvo, Koffi; Agbonon, Amégnona; Gbéassor, Messanvi

doi:10.31254/phyto.2019.8307

Cited by 6 publications

(3 citation statements)

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“…The radical scavenging and antioxidant activities, as well as the therapeutic potentials of M. whitei leaf and root extracts, have been reported (17,33). However, not much is known about the ethnopharmacological properties of the fruit extract.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Anadozie

Adewale

Akawa

et al. 2022

J Herbmed Pharmacol

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Introduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and is known for its nutritional and medicinal uses. This study evaluated the protective effect of M. whitei fruit against cadmium-induced hepatic damage in rats. Methods: Twenty-five albino (Wistar strain) rats were randomly assigned into five equal groups. Rats in group I served as control, rats in group II were intoxicated with 5 mg/kg body weight (b.w.) cadmium chloride (CdCl2 ) for 5 days via an oral route, while groups III, IV, and V were respectively administered with 5 mg/kg b.w. CdCl2 for 5 days co-treated with 70 mg/kg b.w silymarin, 250 and 500 mg/kg b.w. of aqueous fruit extract of M. whitei (AEMW) for 7 days. Results: Cadmium caused a significant (P<0.05) increase in the concentration of cadmium in the liver as well as liver function markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. In addition, a significant (P<0.05) elevation in the level of malondialdehyde (MDA) and a reduction in the nitric oxide (NO) and antioxidant status were noted in the CdCl2 -exposed rats; hepatic degeneration and congested portal area were also noted. These changes were, however, reduced in the cadmium-intoxicated rats co-treated with silymarin, 250 mg/kg or 500 mg/kg AEMW. Conclusion: Our result suggests that AEMW exerts protective effects against CdCl2 -induced hepatic damage in rats, and this might be due to the presence of phytochemicals in the plant capable of scavenging oxidative stress caused by cadmium.

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Section: Discussionmentioning

confidence: 99%

Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Anadozie

Adewale

Akawa

et al. 2022

J Herbmed Pharmacol

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“…This is due to many positive aspects such as its diversity, availability, low cost, efficacy and low side effects [8]. However, in low-income countries, traditional healers most often use plant extracts in the long and short term without knowledge of the toxic effects that these could cause [9]. This situation could most often lead to toxic effects especially on the liver [9; 10], or even to death [11].…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and effect of subacute administration of "4 heures du matin" bitters on anthropometric and hematological parameters in Wistar rats

Kouassi¹,

Kouakou²,

Oussou³

et al. 2022

GSC Biol. and Pharm. Sci.

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"Bitters" are macerations of medicinal plants in alcohol, widely consumed for various reasons. Despite their high consumption, there is little scientific data on their safety/toxicity profile. Therefore, this study aims to assess the acute toxicity and the effect of subacute administration of "4 heures du matin” bitters, consumed to correct erectile dysfunction. The acute toxicity tests were conducted on female rats with the equivalent of 17 or 22 cups corresponding to doses of 1190 and 1540 ml/kg bw. Clinical signs of toxicity and animal death were assessed. For the subacute toxicity study, 70 rats including 35 females and 35 males divided into 3 groups were used. The group 1 rats received orally distilled water. Those in groups 2 and 3, subdivided into 3 subgroups each, received the respective doses of 140; 280 and 420 ml/kg bw of “koutoukou” and “4 heures du matin” bitters daily for 28 days. The body weight of the rats was weekly assessed. Blood samples were taken for hematological analysis. The results of acute toxicity study showed clinical signs of toxicity in rats. "4 heures du matin" bitters caused mortalities ranging from 40 to 60% of the total number of rats. The anthropometric study showed a non-significant increase in the weight of experimental rats. At the haematological level, a significant increase (p<0.001) in MCHC levels and a significant drop in hematocrit percentages was highlighted in male rats gavaged with “koutoukou”. On the leukocyte, the solutions did not induce significant changes in both sexes of rats. The “4 heures du matin” bitters can be considered relatively safe for low-dose consumption in a short period. However, the long-term and high-dose consumption of this bitter poses a huge risk and harmful effect that could compromise the health of consumers.

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“…In low-income countries where most of the population engage in herbal medicine, the use of plants remains traditional [ 23 ]. But, the scientific knowledge about biological properties of active compounds of these plants as well as the doses to be administered is ignored and most of the time this situation leads to treatment failures [ 24 ]. It has been demonstrated that many traditional beneficial herbs have genotoxic or systemic (liver and kidney) toxicity [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Sindete

Gbankoto

Osseni

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Plant medicine is the oldest form of health care known to mankind; hence, studies on their safety for use are essential for the control of adverse drug effects. In Benin, Caesalpinia bonduc is one of many medicinal plants used as aphrodisiac, and for treatment of various ailments including prostatic hyperplasia. Despite its numerous ethnomedicinal benefits, toxicological information associated with its chronic use is currently limited. Objective. The present study therefore assessed the toxicity of an ethanolic root extract of Caesalpinia bonduc in Wistar rats. Methods. Caesalpinia bonduc root extract was administered by oral gavage at doses of 31.25, 125, and 500 mg/kg/day for 90 days to male Wistar rats, after which body weight changes, food consumption, urinary parameters, hematological and blood biochemical parameters, organ weights changes, gross pathology, and histopathology of vital organs were assessed. Results. There were no death or abnormal clinical signs, no significant changes in body weight gain or urinary parameters, and no changes in necropsy and histopathology findings of vital organs associated with extract treatment. However, some indices such as erythrocytes, total cholesterol, and aspartate amino transferase increased in rats treated with high doses of the extract, as well as relative weight of testes, followed by a decrease in food intake and prostate relative weight. Conclusion. The results indicate that an ethanolic root extract of Caesalpinia bonduc does not cause significant adverse effects and suggest its tolerability up to 500 mg/kg for daily administration of 90 days.

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Toxicity and antioxidant activity of Syzygium aromaticum, Mondia whitei, Carissa spinarum and Caesalpinia bonduc

Cited by 6 publications

References 0 publications

Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats

Acute toxicity and effect of subacute administration of "4 heures du matin" bitters on anthropometric and hematological parameters in Wistar rats

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

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