Toxicité hépatique et rénale de la fluindione (Préviscan®)

Cadranel, J.; Demontis, R; Seddik, Mimouna; Ramdani, Sofiane; Belloula, D.; Biour, M

doi:10.1016/j.gcb.2008.07.003

Cited by 3 publications

(2 citation statements)

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“…[ 4 ] Fluindione is the most prescribed oral anticoagulant in France (it represents nearly 80% of all prescribed anticoagulants). [ 5 ] Since 1987, hepatic and renal adverse effects through immunoallergic mechanisms have been well documented with fluindione. [ 5 ] Association of DRESS syndrome to fluindione was first desbribed by Sparsa et al [ 6 ] Since then, 36 cases of DRESS syndrome associated to fluindione were reported in a 10 years period.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 ] Since 1987, hepatic and renal adverse effects through immunoallergic mechanisms have been well documented with fluindione. [ 5 ] Association of DRESS syndrome to fluindione was first desbribed by Sparsa et al [ 6 ] Since then, 36 cases of DRESS syndrome associated to fluindione were reported in a 10 years period. [ 7 ] The mean time-to-onset of DRESS syndrome after fluindione treatment was 28.4 days; occurrence was more rapid in patients with previous hypersensitivity syndrome with a chemically related drug.…”

Section: Discussionmentioning

confidence: 99%

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DRESS syndrome with thrombotic microangiopathy revealing a Noonan syndrome

Bobot

Coen

Simon³

et al. 2018

Medicine

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Rationale:The life-threatening drug rash with eosinophilia and systemic symptoms (DRESS) syndrome occurs most commonly after exposure to drugs, clinical features mimic those found with other serious systemic disorders. It is rarely associated with thrombotic microangiopathy.Patient concerns:We describe the unique case of a 44-year-old man who simultaneously experienced DRESS syndrome with thrombotic microangiopathy (TMA) after a 5 days treatment with fluindione.Diagnoses:Clinical evaluation leads to the discovery of an underlying lymphangiomatosis, due to a Noonan syndrome.Intervetions:The anticoagulant was withdrawn, and corticosteroids (1 mg/kg/day) and acenocoumarol were started.Outcomes:Clinical improvement ensued. At follow-up the patient is well.Lessons:The association of DRESS with TMA is a rare condition; we believe that the presence of the underlying Noonan syndrome could have been the trigger. Moreover, we speculate about the potential interrelations between these entities.

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Section: Discussionmentioning

confidence: 99%