Toxicidad por neonicotinoides: revisión de tema y reporte de dos casos

Atehortúa, Andrés Felipe Estrada; Mejía, Marie Claire Berrouet; Giraldo, Jaime Andrés

doi:10.18566/medupb.v35n1.a06

Cited by 5 publications

(9 citation statements)

References 10 publications

(22 reference statements)

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“…In Colombia, Estrada et al signaled two cases admited with digestive manifestations, coma (Glasgow score 6 and 3, respectively) and respiratory failure with 70-75% Sa O 2 . One of the patients also presented dormant miosis and was thus given atropine [37]. In Saudi Arabia, there was a case with generalized erythematous maculopapular rash typical of leukoclastic vasculitis, which was conirmed by biopsy.…”

Section: Sri Lankamentioning

confidence: 97%

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Acute Poisoning with Neonicotinoid Insecticide

Nistor¹,

Frăsinariu²,

Ştreangă³

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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Neonicotinoids are a class of insecticides considered less toxic to humans than organophosphates, carbamates, organochloride and pyrethroids. The purpose of this chapter was to systematize existing data in the literature on acute intoxication with neonicotinoids to help practitioners. Clinical manifestations vary across diferent human systems.Gastrointestinal symptoms consist of nausea, vomiting, abdominal pain and corrosive lesions. In the central nervous system, headaches, agitation, confusion, fasciculations, seizures or coma may occur, while tachycardia or bradycardia, hypertension, hypotension and palpitations occur in the cardiovascular system. Respiratory efects are dyspnea, aspiration pneumonia or respiratory failure. Solvents that drive the insecticide also have an important role in the toxic efects. There are no speciic biological tests of neonicotinoid intoxication, and their dosing is not routinely available. Treatment is symptomatic. Mortality is less than 3%, well below the poisoning with anticholinesterase insecticides, like organophosphates and carbamates.

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Section: Sri Lankamentioning

confidence: 97%

“…Thus, eight cases were reported in India [27][28][29][30][31][32][33], two in Turkey [34,35], two in Portugal [36], two in Colombia [37], two in Japan [38], one case in Saudi Arabia [39], Iran [40], Poland [41] and four cases in Taiwan [41][42][43][44][45].…”

Section: Poisoning -From Specific Toxic Agents To Novel Rapid and Simmentioning

confidence: 99%

Acute Poisoning with Neonicotinoid Insecticide

Nistor¹,

Frăsinariu²,

Ştreangă³

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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“…is chemical property limits these compounds to overpass the blood-brain barrier (BBB) [20]. In addition to the high selectivity of these pesticides on the nicotinic acetylcholine receptors (nAChRs) of insects, they have been given safety profiles favorable to humans [11].…”

Section: Discussionmentioning

confidence: 99%

“…Neonicotinoid insecticides such as clothianidin and thiacloprid are first-generation, water-soluble compound pesticides [ 18 , 19 ]. This chemical property limits these compounds to overpass the blood-brain barrier (BBB) [ 20 ]. In addition to the high selectivity of these pesticides on the nicotinic acetylcholine receptors (nAChRs) of insects, they have been given safety profiles favorable to humans [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats

Mora-Gutiérrez

Guevara

Rubio

et al. 2021

Journal of Toxicology

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Neonicotinoids are pesticides that act as agonists of nicotinic receptors for acetylcholine in insects’ central nervous system (CNS). Chronic exposure to neonicotinoids in humans is related to autism, memory loss, and finger tremor. In this article, we evaluate the effect of subchronic oral administration of two neonicotinoids in the same mixture: clothianidin and thiacloprid. Decreasing doses of both pesticides were administered to rats starting from the lethal dose 50 (LD50) reported by the manufacturer. Our results indicate that the administration of three doses of decreasing amounts of LD50 (5/10, 4/10, and 3/10 LD50) resulted in 100% death in all cases. Ten administration times of 2/10 LD50 of the mixture caused only 20% of death cases after twenty-seven days, which was determined as a subchronic administration scheme. The animals administered 2/10 LD50 showed behavioral alterations after the first and second administration. Electrographic studies showed abnormal discharge patterns in the CNS. 72 h after the tenth dose, learning and memory tests were performed in the Morris water maze. Our results revealed significant decreases in permanence at the quadrant and the number of crosses ( P = 0.0447 , P = 0.0193 , respectively), which represent alterations in the short-term memory test, but there were no significant changes in a long-term memory test. Likewise, the brains of these animals showed tissue architecture loss, nucleosomal retraction, and a significant increase in the pycnosis of the granular neurons of the dentate gyrus analyzed at 72 h after the last dose ( P = 0.0125 ). Toxic effects and cognitive deterioration that have been found in communities living near contaminated areas are probably related to the agricultural use of neonicotinoids.

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“…methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine) is a broad spectrum insecticide of the neonicotinoid group, used either as a foliar spray or as a seed treatment (Maienfisch et al, 2002;Nauen et al, 2003;Mourtzinis et al, 2019). Substances in this group are agonists of the post-synaptic nicotinic acetylcholine receptors (nAChRs), which makes them efficient insecticides (Jeschke and Nauen, 2008;Estrada Atehortúa et al, 2016).…”

Section: New Insights Into the Mode Of Action Of Thiamethoxam On Seed...mentioning

confidence: 99%

New insights into the mode of action of thiamethoxam on seed germination physiology

et al. 2022

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In order to contribute to understanding the mode of action of the thiamethoxam in plants, we have carried out a virtual screening and in silico molecular docking study with TIA. The pharmacophoric search for protein ligands with three-dimensional structures similar to TIA resulted in several protein ligands with Tanimoto score equal to or greater tha 0.5, but only the ligand isoniazid (ISZ) was bound to a protein from plant origin, which was an ascorbate peroxidase (APX). Molecular docking of ISZ and TIA to several APX’s revealed that TIA binds more strongly to these enzymes than ISZ, suggesting that TIA acts on plants through inhibition of this enzyme. When seedlings obtained from wheat and soybean seeds treated with different concentrations ot TIA, the activity of APX decreased with increasing TIA concentration. Therefore, both in silico and experimental results suggest that TIA can promotes plant growth through inhibition of the enzyme APX

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Toxicidad por neonicotinoides: revisión de tema y reporte de dos casos

Cited by 5 publications

References 10 publications

Acute Poisoning with Neonicotinoid Insecticide

Acute Poisoning with Neonicotinoid Insecticide

Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats

New insights into the mode of action of thiamethoxam on seed germination physiology

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