Toxicidad ocular de la quimioterapia sistémica anticancerosa

Omoti, A E; Omoti, Caroline Edijana

doi:10.4321/s1885-642x2006000200001

Cited by 35 publications

(15 citation statements)

References 35 publications

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“…These changes are in the form of reduced amplitude of the ERG waves (a-and b-), which suggests functional changes in the retina. This finding is in agreement with Omoti (2006) and Ozkan et al (2013). Retina Figure 6.…”

Section: Discussionsupporting

confidence: 89%

Apoptosis and electroretinogram after intravitreal injection of methotrexate in an experimental rabbit model

Aly

Ebrahim²

2016

gpb

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The aim of this study was to explore the changes in electroretinogram of rabbit retina and apoptosis in methotrexate-induced toxicity. Rabbits were divided into 5 groups. Group I served as control in which saline solutions was injected intravitreally. Methotrexate (800 μg, 1.76 μmol) was injected into the vitreous of both eyes of rabbits groups II, III, IV and V by an insulin injector with a 26 gauge needle under general anesthesia. Retinal function was assessed by electroretinogram (ERG) after 2, 4, 10 days and one month then animals were decapitated. The eyes were enucleated and processed for DNA fragmentation studies by gel electrophoresis to retinae and measurement of caspase-3 activities. The results indicated a significant reduction (p ˂ 0.05) in a- and b-wave, a time-dependent appearance of the typical ladder pattern of internucleosomal fragmentation, a characteristic of apoptosis and increase of relative caspase-3 activity after methotrexate intravitreal injection. Methotrexate lead to apoptosis, increase of caspase-3 and affect retinal function.

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Section: Discussionsupporting

confidence: 89%

Apoptosis and electroretinogram after intravitreal injection of methotrexate in an experimental rabbit model

Aly

Ebrahim²

2016

gpb

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“…[1][2][3][4] The development of new cancer therapy strategies that are highly specic to tumor cells for cancer treatment with high efficacy and low side effects is thus urgently needed. [1][2][3][4] The development of new cancer therapy strategies that are highly specic to tumor cells for cancer treatment with high efficacy and low side effects is thus urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

et al. 2014

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Upconversion nanoparticles (UCNPs) have drawn much attention in cancer imaging and therapy in recent years. Herein, we for the first time report the use of UCNPs with carefully engineered surface chemistry for combined photodynamic therapy (PDT) and gene therapy of cancer. In our system, positively charged NaGdF4:Yb,Er UCNPs with multilayered polymer coatings are synthesized via a layer by layer strategy, and then loaded simultaneously with Chlorin e6 (Ce6), a photosensitizing molecule, and small interfering RNA (siRNA), which targets the Plk1 oncogene. On the one hand, under excitation by a near-infrared (NIR) light at 980 nm, which shows greatly improved tissue penetration compared with visible light, cytotoxic singlet oxygen can be generated via resonance energy transfer from UCNPs to photosensitizer Ce6, while the residual upconversion luminescence is utilized for imaging. On the other hand, the silencing of Plk1 induced by siRNA delivered with UCNPs could induce significant cancer cell apoptosis. As the result of such combined photodynamic and gene therapy, a remarkably enhanced cancer cell killing effect is realized. Our work thus highlights the promise of UCNPs for imaging guided combination therapy of cancer.

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“…Unfortunately, no in vivo confocal microscopy facility was available in our unit to visualize the extent of damage to the corneal nerve. In addition, systemic chemotherapy is known to cause ocular side effects, but these are rarely observed with the use of cisplatin which can result in posterior segment toxicity (if it does occur) [24].…”

Section: Discussionmentioning

confidence: 99%

Clinical Spectrum and Outcomes of Ocular and Periocular Complications following External-Beam Radiotherapy for Inoperable Malignant Maxillary Sinus Tumors

Ting

Rana-Rahman

et al. 2020

Ocul Oncol Pathol

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Purpose: To highlight the clinical spectrum, management, and outcomes of ocular/periocular complications following high-dose external-beam radiotherapy (EBRT) for inoperable malignant maxillary sinus-involving tumors (MMST). Methods: A retrospective, interventional case series. All patients who were diagnosed with inoperable MMST (with orbital involvement) and treated with high-dose fractionated EBRT (65 Gy in 30 fractions) at James Cook University Hospital, UK, were included. Results: Seven patients with advanced MMST (T4aN0M0–T4bN2cM0) were included and were followed up for 23.8 ± 10.2 months. Severe lid margin disease, dry eye, and neurotrophic keratopathy were universally observed. Other complications included cicatricial conjunctivitis (71%), corneal perforation (57%), limbal stem cell deficiency (LSCD; 43%), glaucoma (29%), and superimposed candida keratitis (14%). Amniotic membrane transplant (AMT; 71%), tarsorrhaphy (43%), tectonic keratoplasty (29%), and evisceration (14%) were warranted. Intact corneal epithelium was observed in all patients and good corrected-distance visual acuity (≥20/60) was observed in 3 (43%) patients at final follow-up. Conclusion: High-dose EBRT for inoperable MMST can lead to a wide array of severe ocular/periocular complications. AMT serves as a potentially useful treatment modality to restore the ocular surface integrity after severe radiation keratopathy. We advocate active monitoring for any evolving ophthalmic complications during and after EBRT to enable timely intervention.

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Toxicidad ocular de la quimioterapia sistémica anticancerosa

Cited by 35 publications

References 35 publications

Apoptosis and electroretinogram after intravitreal injection of methotrexate in an experimental rabbit model

Apoptosis and electroretinogram after intravitreal injection of methotrexate in an experimental rabbit model

Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

Clinical Spectrum and Outcomes of Ocular and Periocular Complications following External-Beam Radiotherapy for Inoperable Malignant Maxillary Sinus Tumors

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