Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

Wang, Xin; Li, Kai; Yang, Guangbao; Cheng, Liang; He, Lei; Liu, Yumeng; Li, Yonggang; Guo, Liang; Liu, Zhuang

doi:10.1039/c4nr02495h

Cited by 135 publications

(87 citation statements)

References 47 publications

(119 reference statements)

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“…Nanoparticles based on the NaGdF 4 host lattice are being investigated for a variety of applications such as magnetic resonance imaging (MRI) [1][2][3][4][5][6][7][8][9] , multimodal biological labelling/sensing and imaging, 10-21 photodynamic therapy, 10,[22][23][24] spectral conversion in solar cells, 25,26 and nanothermometers. 27,28 NaGdF 4 and other NaREF 4 nanocrystals (RE = rare earth) are often prepared in oleic acid based solvent mixtures yielding very narrow particle size distributions.…”

Section: Introductionmentioning

confidence: 99%

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

2015

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NaGdF 4 nanocrystals of the hexagonal β-phase can be prepared with very narrow size distribution from small particles of the cubic α-phase of NaGdF 4 , but, until now, this method does not allow to control the final particle size. Here we show that the size of β-NaGdF 4 particles can be varied between 4 nm and more than 60 nm by using small α-phase particles with different sodium content as precursor. Heating of the 3-4 nm α-phase particles dispersed in oleic acid/octadecene solvent leads to Ostwald ripening and the formation of β-NaGdF 4 particles with narrow size distribution in all cases. The size of the β-NaGdF 4 particles increases with increasing sodium deficiency of the α-phase particles indicating that the number of β-phase seeds nucleating in the system depends on the ratio of sodium to gadolinium used in the synthesis of the α-phase material.

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Section: Introductionmentioning

confidence: 99%

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

2015

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“…If the absorption spectrum of the photosensitizer overlaps with the emission spectrum of the nanoparticle, the dye should produce singlet oxygen as in PDT. Several articles have also been published on the conjugation of photosensitizers to upconverting nanoparticles, and their indirect activation via infrared excitation of the nanoparticle [22][23][24][25][26][27][28] . The alternative approach of using downconverting nanoparticles has also been investigated, although not as thoroughly 29,30 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of biologically stable, doped LaF3 nanoparticles co-conjugated to PEG and photosensitizers

Bekah

Cooper

Kudinov

et al. 2016

Journal of Photochemistry and Photobiology A: Chemistry

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“…Owing to the existence of Gd 3+ , these nanoparticles could serve as a T 1 MR contrasting agent. Very recently, they demonstrated the synergistic anticancer effect of PDT and gene therapy [92]. In this study, NaGdF 4 :Yb/Er UCNPs were functionalized via LbL coating of counter-charged polymers and then loaded with Ce6 via hydrophobic interaction.…”

Section: Polymer-based Loadingmentioning

confidence: 99%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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Light-activated therapy (LAT) has attracted enormous attention over the past decades because light enables noninvasive activation or release of various therapeutic compounds, such as photosensitizers, chemotherapeutic drugs, proteins, and genes with high spatial and temporal resolution. However, most currently used photosensitive compounds in LAT are sensitive to ultraviolet (UV) or visible light which suffers from some limitations such as low tissue penetration and photodamage to living organisms. Upconversion nanoparticles (UCNPs) that can convert near-infrared (NIR) light to visible/UV light have been proven to be effective for LAT in vivo in recent years, owing to the high tissue penetration and minimal photocytotoxicity of NIR light. Furthermore, hydrophilic UCNPs with targeting moieties can transport hydrophobic drugs in biological media and achieve active targeting, thus enhancing the therapeutic efficacy. In this chapter, we review the recent advances in the field of UCNP-based LAT with focus on photodynamic therapy (PDT) and NIR light-triggered release and uncaging.Keywords Light-activated therapy Á Upconversion nanoparticles Á Near-infrared excitation Á Photodynamic therapy Á Photosensitizer Á Light-triggered drug release Á Uncaging IntroductionThe past decades have seen considerable interest and progress in light-activated therapy (LAT), including photodynamic therapy (PDT), chemotherapy, gene therapy, and photothermal therapy (PTT) as light is noninvasive and controllable both spatially and temporally compared to other stimuli such as temperature, pH, ultrasound, and applied magnetic or electric fields [1,2]. Owing to these Zhenzhen Guo and Fan Zhang contributed together to this chapter.© Springer-Verlag Berlin Heidelberg 2015 F. Zhang, Photon Upconversion Nanomaterials, Nanostructure Science and Technology, DOI 10.1007/978-3-662-45597-5_9 285 advantages, this effective therapeutic approach is beneficial to control drug dosing in terms of quantity, location, and time, hence maximizing therapeutic effect while minimizing side effects [3]. However, the excitation of most commonly used photosensitizers for PDT and photoactive molecules for the release of chemotherapeutic drugs and genes relies on high-energy ultraviolet (UV) or visible light irradiation [4,5]. The tissue penetration depth of UV-visible light is shallow because of the scattering and absorption by tissue chromophores [6]. What is worse, the heterocyclic bases of DNA are major UV-absorbing chromophores in the skin. The absorption leads to damage of the DNA, which may result in the generation of tumors [7]. These limitations would greatly hamper their applications in vivo. Compared to UV and visible light, near-infrared (NIR) light has a larger penetration depth, lower levels of the auto-fluorescence , and photodamage effect [8] and is thus better suited for biomedical applications. Therefore, another component that is capable of converting NIR excitation into UV or visible emission should be introduced into current LAT systems in o...

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Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

Cited by 135 publications

References 47 publications

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

Synthesis and characterization of biologically stable, doped LaF3 nanoparticles co-conjugated to PEG and photosensitizers

Upconversion Nanoparticles for Light-Activated Therapy

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Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

Cited by 135 publications

References 47 publications

Size Control of Nearly Monodisperse β-NaGdF4 Particles Prepared from Small α-NaGdF4 Nanocrystals

Size Control of Nearly Monodisperse β-NaGdF4 Particles Prepared from Small α-NaGdF4 Nanocrystals

Synthesis and characterization of biologically stable, doped LaF3 nanoparticles co-conjugated to PEG and photosensitizers

Upconversion Nanoparticles for Light-Activated Therapy

Contact Info

Product

Resources

About

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals

Size Control of Nearly Monodisperse β-NaGdF₄ Particles Prepared from Small α-NaGdF₄ Nanocrystals