Toxic polyneuropathy of shoe-industry workers. A study of 122 cases.

Cianchetti, Carlo; Abbritti, Giuseppe; Perticoni, G.; Siracusa, Andrea; Curradi, F

doi:10.1136/jnnp.39.12.1151

Cited by 72 publications

(31 citation statements)

References 24 publications

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“…Other authors have stressed that many solvents primarily cause neuropathy, while objective signs of central nervous involvement have been minor, if any (8,48). Our findings of slight positive signs of slowed nE'rve conduction velocities among the car painters and no increase in EEG abnormalities in comparison to the reference group of railroad engineers is similar.…”

Section: Discussionmentioning

confidence: 99%

“…Nerve conduction velocities and electromyographic findings have been published by Italian authors (1,8), and American authors (3, 6) have used ENMG methods as screE'ning tests for cases of methyl-nbutyl ketone-induced neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…Neurophysiological methods have proved sensitive in showing the neurotoxic effects of several industrial chemicals (8,34). We decided to apply these methods in our study, which was focused on car painters exposed to a mixture of organic solvents.…”

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confidence: 99%

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Neurophysiological effects of long-term exposure to a mixture of organic solvents.

Seppäläinen¹,

Husman²,

Martenson³

1978

Scand J Work Environ Health

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effects of long-term exposure to a mixture of organic solvents. Scand. j. work environ. & health 4 (1978) [304][305][306][307][308][309][310][311][312][313][314]. Neurophysiological effects of long-term exposure to a mixture of organic solvents was studied among 102 car painters from 27 car repair garages in Helsinki. The reference group consisted of 102 age-matched railroad engineers from the Finnish State Railways. The mean age was 35 years and the exposure time ranged from 1 to 40 years (mean 14.8, SD 8.5). According to measurements the mean concentration of the solvent mixture was relatively low in the garages, namely, 31.8 % of the Finnish threshold limit value (TLV), the range of separate components varying from 4 to 212 % of the respective TLVs. The main components of about 20 organic solvents of the mixture were toluene, xylene, butyl acetate and white spirit. Electroencephalograms (EEGs) of all the 102 exposed and 102 nonexposed subjects were studied, but electroneuromyographic measurements were made of only 59 car painters and 53 referents with a similar age distribution. Motor (MCV and CVSF) and sensory conduction (SCV) velocities, as well as motor distal latencies, were recorded from nerves in the upper and lower extremities. Abnormal EEGs were encountered in 32 car painters and 37 referents. The frequency of abnormal EEGs was in both groups higher than expected on the basis of EEG literature (about 10 0 /0). Twenty-six car painters had a complex of four common symptoms of disturbances in the central nervous system; the same symptom complex was found in 12 engineers. Forty-six percent of the car painters with this symptom complex had an abnormal EEG, while only 26 Ofo of those without this symptom complex had an abnormal EEG. Railroad engineers did not show such a tendency. Abnormally slow MCVs or SCVs and/or prolonged motor distal latencies were found in 12 of the 59 car painters but in none of the 53 engineers studied. Other authors have stressed that many solvents primarily cause neuropathy, while objective signs of central nervous involvement have been minor, if any. Our findings are similar; they showed slight positive signs of slowed nerve conduction velocities among the car painters and no increase in EEG abnormalities in comparison to the reference group of railroad engineers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neurophysiological effects of long-term exposure to a mixture of organic solvents.

Seppäläinen¹,

Husman²,

Martenson³

1978

Scand J Work Environ Health

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“…Peripheral neuropathy has recently been studied extensively in typical work environments (1,5,7,14), in "sniffers" (8,17,18,23), and in experimental animals (21,27,29,30). In such studies the causes of neuropathy have been n-hexane (14,27,33), trichloroethylene (7), and methyl butyl ketone (1,21,29,31).…”

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confidence: 99%

Clinical neurological findings among car painters exposed to a mixture of organic solvents.

Husman¹,

Karli²

1980

Scand J Work Environ Health

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“…HEX is a neurotoxic solvent and can cause sensorimotor polyneuropathy, mainly affecting distal sensory and motor nerves, both in industrial settings 1−6) and in glue-sniffing addicts 7−10) . In occupationally exposed workers following a sufficient level of exposure to HEX, subjects gradually experience weakness and/or numbness and paresthesia in their distal extremities 2,4,6) . The severity of the neuropathy and the related clinical signs and symptoms are proportional to the intensity, duration and frequency of exposure 9,11,12) .…”

Section: Abstract : a S Y M P T O M A T I C S H O E M A K E R S mentioning

confidence: 99%

Electrophysiological Studies of Shoemakers Exposed to Sub‐TLV Levels of n‐hexane

Neghab

Soleimani

Khamoushian

2012

Journal of Occupational Health

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Sciences, Iran-Background and Objectives: Exposure to n-hexane, a neurotoxic solvent, has been associated with sensorimotor polyneuropathy, both in occupationally exposed workers and in glue-sniffing addicts. The present study was carried out to ascertain whether exposure to sub-TLV levels of n-hexane was associated with electrophysiological abnormalities and to determine if these possible abnormalities have any correlations with parameters such as the biological exposure index (BEI) of this neurotoxic chemical, workers' TWA exposure to n-hexane and/or duration of employment. Materials and Methods: Twenty-seven asymptomatic male workers from 6 shoemaking workshops were studied and compared with a group of 20 age-and sexmatched normal controls with no history of exposure to any neurotoxic agent. They underwent physical examinations as well as conventional needle electromyographic examinations and sensory and motor nerve conduction studies of upper and lower extremities. The TWA exposure to n-hexane and urinary concentration of free 2,5-hexanedione were also determined. Data were analyzed using version 16.0 of the SPSS/PC statistical package. Results: The TWA exposure to n-hexane was estimated to be 83.2 mg/m 3 . Electrophysiological studies showed that the amplitudes of sensory nerve action potential (SAP) for median and sural nerves were significantly lower in exposed subjects than in unexposed normal controls. Additionally, a significant correlation was found between these

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Toxic polyneuropathy of shoe-industry workers. A study of 122 cases.

Cited by 72 publications

References 24 publications

Neurophysiological effects of long-term exposure to a mixture of organic solvents.

Neurophysiological effects of long-term exposure to a mixture of organic solvents.

Clinical neurological findings among car painters exposed to a mixture of organic solvents.

Electrophysiological Studies of Shoemakers Exposed to Sub‐TLV Levels of n‐hexane

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