Toxic nephropathy

Ge, Schreiner; Jf, Maher

doi:10.1016/0002-9343(65)90149-x

Cited by 123 publications

(28 citation statements)

References 248 publications

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“…These changes in GST profile and concentration in the kidney are associated with distention of the S2 and S3 regions of the proximal tubules, as reported earlier by investigators from other laboratories [15][16][17]29].…”

Section: Discussionsupporting

confidence: 78%

“…Mercury was select ed for study because it induces toxic effects on the kidney [15][16][17]. The kidney was examined because of prior find ings that toxic concentrations of heavy metals, including mercuric chloride, increased GST concentrations in the kidney [5,18] and increased urinary levels of GST [19,20], The study reveals that those cell populations showing increases in mGSTA (mouse GST), following toxicant exposure, may be protected from necrosis by the increase in GST and that GST may serve as a biomarker to assess renal injury [21].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increased Levels of Glutathione S Transferases and Appearance of Novel Alpha Class Isoenzymes in Kidneys of Mice Exposed to Mercuric Chloride

McGuire

Daggett

Bostad

et al. 1997

Nephron

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Glutathione S transferases (GST) are a family of enzymes that detoxify electrophilic xenobiotics. This enzyme family was examined in kidneys of mice exposed to mercuric chloride, a known nephrotoxin, because GST have been shown to protect cells against toxicant-induced damage and may serve as biomarkers for toxicant exposure. The purpose of this study was to determine the effect of mercuric chloride on GST activity, isoenzyme levels, and cellular localization in the kidney of Swiss Webster mice. The cellular localizations of alpha, mu, and pi class GST in the kidneys of control and mercuric chloride treated mice were studied immunohistochemically. The GST isoenzyme levels were measured by high-performance liquid chromatography. The mice treated with mercuric chloride had (1) increased amounts of GSTA1/A2 protein in kidney homogenates as compared with controls when analyzed by chromatography and electrophoresis; (2) two new isoforms of the alpha isoenzyme in kidney as demonstrated by Western blot, polyacrylamide gel electrophoresis, and high-performance liquid chromatography, and (3) increased reactivity between antibodies, against GSTA1/A2 or GSTM1 isoenzymes, and cells in the proximal and distal renal tubules as shown by immunohistochemical techniques. The authors conclude that the GSTA1/A2 may protect those cells in the proximal and distal tubules of the renal cortex from toxicant effects of mercuric chloride. This would be one general mechanism for cell protection against a wide variety of toxicants including heavy metals and halogenated aromatics.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Increased Levels of Glutathione S Transferases and Appearance of Novel Alpha Class Isoenzymes in Kidneys of Mice Exposed to Mercuric Chloride

McGuire

Daggett

Bostad

et al. 1997

Nephron

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“…The nephrotoxic effect of carbon tetrachloride has long been recognized: acute renal failure has been ob served in individuals exposed by ingestion and inhala tion [13,14]. Published case reports have demonstrated that short-term high-level exposure to other solvents can result in acute tubular necrosis as well.…”

Section: Acute Tubular Necrosismentioning

confidence: 99%

Solvent Nephrotoxicity in Humans and Experimental Animals

1990

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Evidence from human case reports, epidemiologic studies and animal experiments have suggested that exposure to organic solvents is associated with a wide spectrum of renal disorders, including tubular necrosis, interstitial disease, glomerulonephritis and neoplasia. This review summarizes what is known about solvent-induced renal damage in humans and experimental animals, with emphasis on hypothesized mechanisms by which this broad range of disorders may occur.

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“…In the present study hypokalemia was found only in 23 cancer patients out of 900 patients. [5][6][7][8][9] Hypokalemia is accompanied by enhanced renal cystogenesis and may lead to interstitial scarring and renal insufficiency, and hypokalemia is also associated with end stage chronic kidney disease population. 10,11 In the present study, also it is found that Genito-urinary disorders are the significant contributors of hypokalemia, about 13% of patients had genito-urinary disorders Limitation of this study could not perform the more detailed investigation of the hypokalemia like regarding the mortality, consumption of diuretics, steroids, insulin therapy.…”

Section: Discussionmentioning

confidence: 99%

Hypokalemia in hospitalized patients in tertiary care teaching hospital Belagavi, Karnataka, India: a retrospective study

2017

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Background: Hypokalemia is well known condition in which serum potassium levels falls less than the normal level (normal range 3.5 to 5.1mmol/L). It has adverse effect on cardiac rhythm, blood pressure.1 The objective of the study was to look for causes and associated factors of hypokalemia.Methods: Patients age, sex, potassium value and primary diagnosis of hypokalemia patients collected from tertiary care teaching hospital retrospectively. Hypokalemia patients are classified based on the severity of hypokalemia, age, sex and primary diagnosis. Results: Study reveals that both males and females are equally affected by hypokalemia, individuals with age between 40 to 60 are most affected and less than 20 are least affected by hypokalemia.Conclusions: Hypokalemia is significantly associated with gastrointestinal and genitourinary disorders when compared with other disorders.

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Toxic nephropathy

Cited by 123 publications

References 248 publications

Increased Levels of Glutathione S Transferases and Appearance of Novel Alpha Class Isoenzymes in Kidneys of Mice Exposed to Mercuric Chloride

Increased Levels of Glutathione S Transferases and Appearance of Novel Alpha Class Isoenzymes in Kidneys of Mice Exposed to Mercuric Chloride

Solvent Nephrotoxicity in Humans and Experimental Animals

Hypokalemia in hospitalized patients in tertiary care teaching hospital Belagavi, Karnataka, India: a retrospective study

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