Toxic metal complexes of macrocyclic cyclen molecule – synthesis, structure and complexing properties

Litecká, Miroslava; Gyepes, Róbert; Vargová, Zuzana; Vilková, Mária; Almáši, Miroslav; Walko, Martin; Imrich, Ján

doi:10.1080/00958972.2017.1305493

Cited by 11 publications

(19 citation statements)

References 27 publications

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“…The prepared solutions were then used to examine their antibacterial activity using the agar diffusion method. 4…”

Section: Antibacterial Testmentioning

confidence: 99%

“…These complexes can be incorporated in chemical or biological matrices and used in a variety of environments [3]. TMCs are essential components of the human body's structural and functional elements and play a vital role in many physiological or pathological procedures [4]. TMCs drugs (TMCD) have become increasingly important in inorganic and medicinal chemistry and have attracted a great deal of attention over the past decade in drug development strategies [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…TMCs are essential components of the human body's structural and functional elements and play a vital role in many physiological or pathological procedures [4]. TMCs drugs (TMCD) have become increasingly important in inorganic and medicinal chemistry and have attracted a great deal of attention over the past decade in drug development strategies [4,5]. The studies have also shown that the nanomaterials and nanocomplexes have distinctive physical, chemical and biological applications [6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

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Three nanocomplexes of Cu(II), Co(II), and Ni(II) with theophylline were synthesized by ultrasonic sonication method. This method was used to produce smaller and narrow-distributed nanoparticles without any aggregations. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR) and elemental analysis (C, H, N, and S) were used to identify and to suggest the structure of the synthesized nanocomplexes. The transmission electron microscopy (TEM) results exhibited that the size of nanocomplexes was in the range of 15-25 nm. The efficacy of the synthesized nanocomplexes was examined against four types of bacterial strains, Staphylococcus aureus, Bacillus subtilis (gram-positive bacteria), and Klebsiella pneumoniae, Escherichia Coli (gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as they resulted in an inhibition zone between 98% and 100%. The copper nanocomplex gave the highest inhibition zone by 100% for each type of bacterial strains, due to the surface plasmon. Therefore, a further test for the copper nanocomplex Cu(THP) 2 (H 2 O) 2 (Cl) 2 was carried out on skin injuries of laboratory mice after it was converted into cream with vaseline and was found to have a very potent influence in healing skin injuries.

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“…The prepared solutions were then used to examine their antibacterial activity using the agar diffusion method. 4…”

Section: Antibacterial Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

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“…Organic-metal complexes are important in medicinal chemistry and are widely used for diagnosis purpose and treatment of different diseases such as arthritis, cancer, anti-microbial, anti-fungal and anti-parasitic agents [ 1 – 3 ]. Transition metals are important in the human body and perform several important functions [ 4 ]. Over the past decade, transition metals found an increasing use in drug design and development [ 4 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

et al. 2022

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Background Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts. Results Anthranilic acid complexes (1–10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV–vis spectrometry, mass spectrometry and magnetic susceptibility. The morphology and size of metal complex (1–10) particles were determined by scanning electron microscope (SEM) and the surface area was determined by BET analysis. TGA and CHN analysis data indicated that the stoichiometries of complexes were 1:2 metal/ligand except for Ag(I), Al and Bi. Furthermore, DFT study was performed to optimize the structure of selected complexes. The complexes (1–10) were evaluated for their catalytic activity in the reduction of 4-nitrophenol (4-NP), antibacterial activity against S. aureus, P. aeroginosa and E. coli as well as their antifungal activity against F. solani and A. niger. The complexes were also tested against the second-stage juveniles (J2) root-knot nematodes. Conclusion Co(II) complex 5 and Cu(II) complex 6 showed high catalytic activity for the reduction of 4-NP to 4-aminophenol (4-AP). Ag(I) complex 3 showed the best activity against the pathogens that were tested namely clinically important bacteria S. aureus, P. aeroginosa and E. coli, commercially important fungi F. solani and A. niger and J2 root-knot nematodes M. javanica.

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“…Transition metal complexes drug (TMCD) have become increasingly important in inorganic and medicinal chemistry and have attracted a great deal of attention over the past decade in drug development strategies [6]. Nanotechnology plays an important role in inorganic chemistry through the formation of nano complexes and nano oxides, which are included in many biological and industrial applications [7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(II), Mn(II) and Fe(II) Theophylline Complexes in Nanoscale

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

View full text Add to dashboard Cite

Toxic metal complexes of macrocyclic cyclen molecule – synthesis, structure and complexing properties

Cited by 11 publications

References 27 publications

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies

Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(II), Mn(II) and Fe(II) Theophylline Complexes in Nanoscale

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