Toxic Epidermal Necrolysis Induced by Carbamazepine: A Case Study

Laskar, Jahirul Islam; Chakravarty, Pinaki; Dewan, Babul

doi:10.22159/ajpcr.2017.v10i7.18406

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism involves impairment in lymphocyte transformation with a gradual decrease in cyclic adenosine monophosphate (cAMP) and cell proliferation. Others like ACE inhibitors, frusemide, biguanides etc, could also cause psoriasiform eruptions all over the body [26,27]. With the discontinuation of metoprolol, the lesions and eruptions were found to be reduced and there was no reappearance of lesions when treated with atenolol in its initial stage.…”

Section: Discussionmentioning

confidence: 99%

Case Study on Beta Blockers Induced Psoriasis

Rajan¹,

Jeyamani²,

Kaviya³

et al. 2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Drug-induced Psoriasis is one among the common etiological factors of Psoriasis reported worldwide. Familiar drugs known to cause psoriasiform eruptions include Anti-malarials, Beta blockers, NSAIDs, Lithium. etc. Certain antihypertensives like ACE inhibitors, diuretics are also documented to have caused psoriatic episodes. A 57 y old South-Indian male patient with a history of Hypertension, Diabetes Mellitus, Atrial Fibrillation for 4 y; was on antihypertensive therapy for Hypertension and Atrial Fibrillation with proponolol for past 2 y and metoprolol initially. He was presented to the hospital two weeks after switching on to Metoprolol therapy for chief complaints of erythematous scaly lesions especially over both the extremities and paronydrial appearance of nails. Initially, he was on Propranolol therapy which was then shifted to Metoprolol due to an appearance of oral lesions in the mouth. Metoprolol was now discontinued and switched on to Atenolol. After 1-2 w of therapy with Atenolol, the lesions were found to disappear and no recurrence of psoriatic conditions were found. Proper reviewing of medical history for any allergic reactions and the optimization of drug therapy through Therapeutic Drug Monitoring could be initiated by Clinical Pharmacist in order to avoid such drug-induced flares.

show abstract

Section: Discussionmentioning

confidence: 99%

Case Study on Beta Blockers Induced Psoriasis

Rajan¹,

Jeyamani²,

Kaviya³

et al. 2019

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

Carbamazepine

2017

Reactions Weekly

View full text Add to dashboard Cite

Case Reports of Stevens Johnson Syndrome (SJS) Induced by Chemically Unrelated Drugs

Vangoori¹,

Kandra

Uppala³

et al. 2023

RJPT

View full text Add to dashboard Cite

Stevens-Johnson syndrome (SJS) is considered as serious mucocutaneous autoimmune disease which is potentially fatal. It may be initiated by medical treatment or infection and sometimes both may be triggering factors. Skin reactions involving loss of skin and mucus membrane and in severe cases, systemic symptoms may be appeared in SJS. In most of the cases medication is the causative factor. Toxic Epidermal Necrolysis (TEN) is a severe form of SJS, as it involves more than 30% of the skin surface with extensive damage to the mucous membranes. SJS and TEN are distinguished based on the extent of the detached skin surface area. It starts with flu-like symptoms, rashes with pain; the upper layer of affected skin dies, sheds and begins to heal after several days. In severe cases, it may leads to life threatening condition. Here we are presenting drug induced SJS in three different cases with different drugs. In first case, a 40-years male treated with Phenytoin 400mg for epilepsy, in second case, a 50-years male was given Amoxicillin + clavulanic acid-625 for some skin lesions and in third case, 50-years old female was given Methotrexate 7.5mg for Rheumatoid arthritis. In all the three cases, SJS symptoms were started within a period of 5-10days. All the symptoms and reactions were noticed and assessed for the confirmations of SJS.

show abstract

Toxic Epidermal Necrolysis Induced by Carbamazepine: A Case Study

Cited by 3 publications

References 13 publications

Case Study on Beta Blockers Induced Psoriasis

Case Study on Beta Blockers Induced Psoriasis

Carbamazepine

Case Reports of Stevens Johnson Syndrome (SJS) Induced by Chemically Unrelated Drugs

Contact Info

Product

Resources

About