Toxic Epidermal Necrolysis and Acute Kidney Injury due to Glyphosate Ingestion

Indirakshi, J; Sunnesh, A; Aruna, M; Reddy, Munish; Kumar, Avnish; Chandra, V. Sarat; Sangeetha, B; Katyarmal, D.T.; Ram, R; Kumar, V Siva

doi:10.4103/ijccm.ijccm_423_16

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…2,3 However, adverse effects have been reported in individuals exposed to glyphosate, including cutaneous adverse reactions. For instance, a case of toxic epidermal necrolysis due to ingestion of glyphosate has been described, 4 as well as skin reactions secondary to direct contact with glyphosate in the occupational setting, predominantly chemical burns and irritant contact dermatitis (ICD). 5,6 A case of contact dermatitis with a delayed erythema multiforme-like reaction on the abdomen hours after contact with the arms during fumigation labour has also been published.…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused by herbicide containing glyphosate‐isopropylamine salt

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused by herbicide containing glyphosate‐isopropylamine salt

et al. 2022

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The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease

et al. 2022

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The usage of glyphosate is increasing worldwide. Glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern in unknown chronic kidney disease (CKDu). As with Cd and other elements, glyphosate exposure has been reported as risk factor for CKDu in farmers. This study aimed to evaluate the in uence of co-exposure to glyphosate and heavy metals in chronic kidney disease. In this study, the urine samples from 55 patients with CKD and 100 participants without CKD were analyzed for glyphosate, As, Cd, and Pb concentrations, and eGFR. Negative associations between glyphosate, AMPA, As, and Cd concentrations in the urine and eGFR were found for study subjects (p < 0.05). With regard to the effect of co-exposure, the odds ratios (OR) for subjects with an eGFR of < 60 mL/min/1.73 m 2 was signi cant because of the high Cd concentration (> 1 µg/g creatinine; OR = 7.57, 95% CI = 1.91-29.95). With regard to the effect of co-exposure, the OR for subjects with an of eGFR < 45 mL/min/1.73 m 2 was signi cant at high glyphosate concentration (> 1 µg/g creatinine; OR = 1.57, 95% CI = 1.13-2.16) and As concentration (> 1 µg/g creatinine; OR = 1.01, 95% CI = 1.00-1.02). These results showed that glyphosate, AMPA, As, and Cd have an effect on CKD; notably, Cd, As, and glyphosate exposure can be important risk factors after stage 3a of CKD, and that there was a co-exposure effect of As and glyphosate in CKD after stage 3b.The potential health impacts of glyphosate should be considered, especial for patients with CKD and eGFR below 45 mL/min/1.73 m 2 .

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Toxic Epidermal Necrolysis and Acute Kidney Injury due to Glyphosate Ingestion

Cited by 2 publications

References 10 publications

Allergic contact dermatitis caused by herbicide containing glyphosate‐isopropylamine salt

Allergic contact dermatitis caused by herbicide containing glyphosate‐isopropylamine salt

The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease

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