Toxic Epidermal Necrolysis

Potter, Brian; Auerbach, Robert; Lorincz, Allan L.

doi:10.1001/archderm.1960.01580060057006

Cited by 22 publications

(4 citation statements)

References 6 publications

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“…The lesions were virtually restricted to the epidermis, the dermis showing only minor secondary changes. Although this was the first recorded grouping of the syndrome other isolated cases of a similar nature had been previously reported under a variety of descriptive names (Lang andWalker, 1956, see Potter, Auerbach andLorincz, 1960). Since LyeU's publication there have been many additional reports of similar cases in the literature.…”

supporting

confidence: 56%

“…A second feature over which some doubt exists is whether acantholysis occurs. It has been observed by some (Potter, Auerbach and Lorincz, 1960 ;Minkowitz, 1965) and denied by others (Frain-Bell and Koblenzer, 1961 ;WoM, 1965). In our material there was no evidence of typical acantholysis and we do not beheve that the bullae result from an acantholytic process.…”

Section: Discussionmentioning

confidence: 91%

“…The exact site of bulla formation is variously reported as intra-epidermal (Potter, Auerbach and Lorincz, 1960 ;Helfman, 1964 ;and Minkowitz, 1965), or sub-epidermal (Bailey, Eosenbaum and Anderson, 1965). Eowell and Thompson (1961) state that the cleavage can occur in both sites depending on the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Toxic Epidermal Necrolysis (Lyell's Disease)

Shilkin

Huston

1966

Australas J Dermatol

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SUMMARY Two cases of “toxic epidermal necrolysis” with a fatal outcome are reported. The histological features have been assessed and it is believed that in this condition bullae form as a result of coalescence of intra‐epidermal vesicles which themselves have formed from the rupture of numerous intracellular vacuoles. Acantholysis did not occur. Although there was a history of drug ingestion in both cases the etiological role of these, or of intercurrent disease, was unhelpful in elucidating the pathogenesis of the syndrome.

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supporting

confidence: 56%

Section: Discussionmentioning

confidence: 91%

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Toxic Epidermal Necrolysis (Lyell's Disease)

Shilkin

Huston

1966

Australas J Dermatol

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“…Thirteen cases in adults G-D, 1:!. 14 and ten cases in children ~-4~; 11 Review of the systems was negative. Temperature was 98.6°; pulse, 120; respirations, not recorded; weight, 20 lb.…”

mentioning

confidence: 94%

Toxic Epidermal Necrolysis (Scalded Skin Syndrome)

Baird

Reichelderfer

1963

Clin Pediatr (Phila)

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Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments

Elias¹

1977

Archives of Dermatology

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The essential clinical features of staphylococcal scalded skin syndrome (SSSS) and otherforms of toxic epidermal necrolysis (TEN) are contrasted. Whereas TEN is a devastating disease of multiple causes and of high fatality affecting all age groups, SSSS comprises many clinical entitles that occur primarily in early childhood and is caused by certain phage group 2 staphylococci. Because of the high cleavage plane, the barrier is only translently perturbed, and rapid recovery is the rule. Although the early stages of SSSS may resemble other widespread dermatoses clinically, the correct diagnosis is suggested, even prior to frank exfoliation, by the presence of cutaneous tenderness and a positive Nikolski sign. However, rapid bedside confirmation is now possible with exfoliative cytology and frozen sections. Recent availability of in vivo and in vitro animal models of SSSS have advanced the knowledge of the disease: the responsible epidermolytic toxin has been characterized, and the purely extracellular pathogenesis of SSSS has been established. The epidermolytic toxin is strikingly species and tissue specific, attacking only certain keratinizing epithelia of mice, hamsters, monkeys, and man. The lower incidence of SSSS in adults is primarily due to a supreior capacity to metabolize and excrete the toxin, as well as more efficient immune capabilities. The mechanisms of epidermolytic toxin action and the molecular site of action are still the focus of active investigation.

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Toxic Epidermal Necrolysis

Cited by 22 publications

References 6 publications

Toxic Epidermal Necrolysis (Lyell's Disease)

Toxic Epidermal Necrolysis (Lyell's Disease)

Toxic Epidermal Necrolysis (Scalded Skin Syndrome)

Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments

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