Toxic Epidermal Necrolysis (Lyell's Disease)

Abstract

SUMMARY Two cases of “toxic epidermal necrolysis” with a fatal outcome are reported. The histological features have been assessed and it is believed that in this condition bullae form as a result of coalescence of intra‐epidermal vesicles which themselves have formed from the rupture of numerous intracellular vacuoles. Acantholysis did not occur. Although there was a history of drug ingestion in both cases the etiological role of these, or of intercurrent disease, was unhelpful in elucidating the pathogenesis of the syndrome.