Toxic effects of Lambda-cyhalothrin, on the rat thyroid: Involvement of oxidative stress and ameliorative effect of ginger extract

Al-Amoudi, Wael M.

doi:10.1016/j.toxrep.2018.06.005

Cited by 43 publications

(24 citation statements)

References 73 publications

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“…In the current study, terminal body weight and relative weight of liver of LCT-intoxicated rats were reduced that run in a good agreement with previous studies [14,[45][46][47][48]. Elhalwagy et al [1] demonstrated that decreasing body weight and organs relative weight is one of the chronic effects of pyrethroids toxicity.…”

Section: Discussionsupporting

confidence: 91%

Histological, ultrastructural, and biochemical study on the possible role of Panax ginseng in ameliorating liver injury induced by Lambda cyhalotherin

Abdul-Hamid

Mohamed

El‐Twab

et al. 2020

Beni-Suef Univ J Basic Appl Sci

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Background Lambda-cyhalotherin (LCT) is a pyrithroid type 2 pesticide that is broadly utilized in pest control in public health, animal health, and agriculture. Although claiming that LCT has a low mammalian toxicity, several investigations reported its mammalian hepatotoxicity by mediating oxidative stress causes severe hepatotoxicity and liver damage. Results LCT significantly decreased catalase (CAT), superoxide dismutase (SOD), and total thiol (T. thiol) and increased lipid peroxidation (LPO). mRNA and protein expression levels of p53 were upregulated, whereas Bcl-2 mRNA and protein expression levels were downregulated in LCT-intoxicated animals. Also, light microscopic and ultrastructure studies for liver tissues of LCT-intoxicated animals showed mononuclear leukocytic infiltration in the parenchyma, congested portal vein with thickened wall, and proliferation of bile duct and hepatocytes with cytoplasmic vacuolations, fatty changes, and collagen fibers. Panax ginseng co-treatment attenuated oxidative stress biomarkers. Both tested doses of Panax ginseng (100 and 200 mg /kg b. wt./day) significantly decreased p53 and elevate Bcl-2 mRNA and protein expression levels and reveals significant amelioration and restoration of normal histology and ultrastructure of liver, but 200 mg/kg b. wt. of Panax ginseng seems to be more potent. Conclusion Panax ginseng exhibited ameliorative effect against hepatic oxidative stress, apoptosis, histopathological, and ultrastructural changes induced by LCT.

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Section: Discussionsupporting

confidence: 91%

Histological, ultrastructural, and biochemical study on the possible role of Panax ginseng in ameliorating liver injury induced by Lambda cyhalotherin

Abdul-Hamid

Mohamed

El‐Twab

et al. 2020

Beni-Suef Univ J Basic Appl Sci

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“…Similarly, Al-Amodie stated that ginger extract improved the histochemical and histological changes of the thyroid gland induced by insecticide Lambda-cyhalothrin. Furthermore; it increased T3 and T4 and decreased TSH hormones levels, decreased MDA level the lipid peroxidation marker and increased the antioxidant enzymes (25) .Another study revealed the ameliorative role of ginger extract on the insecticide mancozeb toxicity of the thyroid gland in rats (26) . Yousef et al .suggested that administration of ginger extract was a valuable routine for protection in opposition to the damaging effect of cypermethrin in the thyroid gland structure (10) .Other study proved that the antioxidative, anti-inflammatory and antiapoptotic functions were the most effective role of ginger in protection against chlorpyrifos toxicity in the brain and reproductive organs of rats (27) .…”

Section: Discussionmentioning

confidence: 93%

Ameliorative Effect of Ginger Extract and Selenium in theThyroid Gland Toxicity Induced by Chlorpyrifos in Male Albino Rats

Elkerdasy

Elsayed

Mousa

2021

The Egyptian Journal of Hospital Medicine

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Background: Chlorpyrifos CPF is one of the organophosphate insecticides that were interfered with the body's hormones. Thyroid hormones are necessary to maintained normal metabolism, growth and development and the disturbance of their levels leads to adverse medical conditions. Ginger extract and selenium are effective antioxidants. Aim of the work: This study examined effect of CPF on the thyroid gland structure and function and the ameliorative effect of ginger extract and selenium. Material and Methods: forty rats were categorized into four groups. Control group I, group II: rats were given CPF at a dose of 6.7 mg/kg orally five days / week for six weeks, group III: rats were given CPF and ginger extract at a dose of 750 mg/kg orally, five days / week for six weeks. Group IV: rats were given CPF and sodium selenite 10 µg/Kg orally five days / week for six weeks, blood samples were taken for hormonal essay. Thyroid gland specimens were prepared for the histological and immunohistochemical studies. Results: chlorpyrifos induced functional toxic effect and destruction of the thyroid gland histological structures. There was a significant decrease in area % of the colloid and a significant increase in mean number of PCNA positive nuclei in comparison with the control group. Ginger extract and selenium eliminated the damage effect of CPF on the thyroid gland function and histological structure. Conclusion: CPF had adverse effects on the thyroid structure and function that could be eliminated by administration of ginger and selenium.

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“…The level of SOD, Catalase, GSH also showed significant perturbations in rat liver while on of Citrus limon fruit extract markedly ameliorated the toxicity of Carbofuran by protecting the levels of the aforementioned biomarkers to near the control level [19]. Al- [20] reported the protective role of ginger on Lambda cyhalothrin (LC) insecticide, a decrease in SOD and CAT but an increase in the cyhalothrin induced toxicity while LC plus ginger increased the antioxidant enzymes and decreased MDA Cyhalothrin may not have obvious effect on the organ weights, body weight and gonadosomatic indices but silently destroy target cells of the body overtime. A comparison of the trend in liver biomarkers, histopathological analysis of the liver vealed Cyhalothin induce oxidative and reproductive stress in exposed animals while results from groups co-administered Citrullus lanatus and Annona muricata revealed the therapeutic role this indigenous fruit on Cyhalothin-induced toxicity and therefore should be used as Supplement and a suitable first aid for pesticide related poisoning.…”

Section: Resultsmentioning

confidence: 99%

“…The level of SOD, Catalase, GSH also showed significant perturbations in rat liver while administration of Citrus limon fruit extract markedly ameliorated the toxicity of Carbofuran by protecting the levels of the aforementioned biomarkers to near the control level [19]. Amoudi [20] reported the protective role of ginger on Lambda cyhalothrin (LC) inse decrease in SOD and CAT but an increase in the levels of MDA in lambda-cyhalothrin induced toxicity while LC plus ginger increased the antioxidant enzymes and decreased MDA levels.…”

Section: Potential Reproductive Toxicity By Histopathological Analysimentioning

confidence: 99%

Evaluation of the Therapeutic Role of Citrullus lanatus and Annona muricata Fruit Extracts on Cyhalothrin-induced Toxicity

Titus

Orlu

Obulor

2020

JABB

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Aim: The aim of this study is to evaluate the therapeutic role of Citrullus lanatus and Annona muricata fruit Extracts on Cyhalothrin-induced Toxicity. Experimental Design: The study was a completely randomized design employing relevant statistical tools for analysis and interpretation. Place and Duration of Study: The study was carried out in the Reproductive Physiology and Genetics Research Laboratory of the Department of Applied and Environmental Biology, Rivers State University, Rivers State. The experiment lasted for 35 days. Methodology: The body weight of the animals was monitored and recorded twice a week throughout the duration of the experiment. For Biochemical analysis, blood samples were collected by ocular puncture into sterile tubes and serum separated by centrifugation at 2500 g for 10 mins and stored for determination of some liver biomarkers including ALT, ALP, AST, Total Cholesterol and Glucose using their respective kits. For histopathological analysis of Liver and Testis 0.5 g of the each organ was fixed in 10% neutral formalin and sectioned with a digital microtome (AO Spencer, No. 820) at 5 µm thick. Histological sections mounted on slides were stained with Hematoxylin and Eosin (H&E). Photomicrographs were generated at X40 magnification and interpreted. Data from biochemical analyses were subjected to one-way ANOVA. Results: All experimental animals showed a non-significant (P>0.05) increase in body weight throughout the experimental period. The range of values for Organ weight observed in the other treatmental groups were closer to that of the control group than the group exposed to Cyhalothrin only. The level of ALP, AST and ALT significantly p<0.05) increased in groups exposed to Cyhalothrin only but reduced with administration of 100% Citrullus lanatus and Annona muricata extract. Plate 1A shows the normal architecture of seminiferous tubules and spermatogenic elements in the control group, the Seminiferous tubules and epithelium of the group exposed to cyhalothrin only is characterized with large vacuoles devoid of spermatogenic elements. Testicular tissue of animals co-administered Citrullus lantanus and Annona muricata extracts shows regenerating epithelium filled with maturing spermatozoa.. Photomicrograph of the liver epithelium in the control group shows normal architecture of liver cell filled with normal hepatocytes. Hepatocytes degeneration and lesion in the liver cells of animals exposed to Cyhalothrin only was observed (Plate 2B). Plate 2C and D showed regeneration of hepatocytes with fewer lesion in the liver epithelium while fully regenerated liver epithelium of animals was observed in Plate 2 E. Conclusion: Cyhalothrin may not have obvious effect on the organ weights, body weight and gonadosomatic indices but silently destroys target cells of the body overtime. Cyhalothin induced oxidative and reproductive stress in exposed animals while from the groups co-administered Citrullus lanatus and Annona muricata the therapeutic role of this indigenous fruits on Cyhalothin-induced toxicity was observed both in the liver and testicular epithelium and therefore can be used as Supplement and a suitable first aid for pesticide related poisoning.

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Toxic effects of Lambda-cyhalothrin, on the rat thyroid: Involvement of oxidative stress and ameliorative effect of ginger extract

Abstract: Graphical abstract

Cited by 43 publications

References 73 publications

Histological, ultrastructural, and biochemical study on the possible role of Panax ginseng in ameliorating liver injury induced by Lambda cyhalotherin

Histological, ultrastructural, and biochemical study on the possible role of Panax ginseng in ameliorating liver injury induced by Lambda cyhalotherin

Ameliorative Effect of Ginger Extract and Selenium in theThyroid Gland Toxicity Induced by Chlorpyrifos in Male Albino Rats

Evaluation of the Therapeutic Role of Citrullus lanatus and Annona muricata Fruit Extracts on Cyhalothrin-induced Toxicity

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