Toxic effects of chlortetracycline on maize growth, reactive oxygen species generation and the antioxidant response

Wen, Bin; Liu, Yu; Wang, Peng; Wu, Tong; Zhang, Shuzhen; Shan, Xiao-quan; Lu, Jingfen

doi:10.1016/s1001-0742(11)60901-7

Cited by 29 publications

(15 citation statements)

References 28 publications

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“…Tetracyclines and amphenicols (e.g. chloramphenicol) also repress photosynthesis [75,86,91,99]. Although some studies showed that tetracyclines at high concentrations (500 mM) can quickly inhibit chloroplast translation by binding 16S rRNA and blocking the entry of amino-acylated tRNA into the A site of the 70S ribosome [97], in our hands chloroplast translation is 10-fold less sensitive to inhibition than mitochondrial translation [57].…”

Section: Plant Chloroplasts and Mitochondria Are Vulnerable To Antibimentioning

confidence: 52%

“…How can antibiotics inhibit plant growth? Many relevant studies focused on the impact of antibiotics on photosynthesis and oxidative stress response in plants [75,86,[91][92][93][94]. The bacterial origins of chloroplasts and mitochondria explain why they may be vulnerable to antibiotics ( Figs.…”

Section: Plant Chloroplasts and Mitochondria Are Vulnerable To Antibimentioning

confidence: 99%

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Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

et al. 2015

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Recently, several studies have demonstrated that tetracyclines, the antibiotics most intensively used in livestock and that are also widely applied in biomedical research, interrupt mitochondrial proteostasis and physiology in animals ranging from round worms, fruit flies and mice to human cell lines. Importantly, plant chloroplasts, like their mitochondria, are also under certain conditions vulnerable to these and other antibiotics that are leached into our environment. Together these endosymbiotic organelles are not only essential for cellular and organismal homeostasis stricto sensu, but also have an important role to play in the sustainability of our ecosystem as they maintain the delicate balance between autotrophs and heterotrophs, which fix and utilize energy, respectively. Therefore, stricter policies on antibiotic usage are absolutely required as their use in research confounds experimental outcomes, and their uncontrolled applications in medicine and agriculture pose a significant threat to a balanced ecosystem and the wellbeing of these endosymbionts that are essential to sustain health.

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Section: Plant Chloroplasts and Mitochondria Are Vulnerable To Antibimentioning

confidence: 52%

Section: Plant Chloroplasts and Mitochondria Are Vulnerable To Antibimentioning

confidence: 99%

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

et al. 2015

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“…CTC can inhibit the nitrification of the soils at concentrations >100 mg/kg [36]. Among plants, maize seems to be one of the most sensitive species to CTC and root elongation, the most sensitive endpoint, has an EC 50 = 2.28 mg/kg for this parameter [37] [38]. The effects of TCs on wheat only appear at higher concentrations [39].…”

Section: Potential Risk Assessment Of Tcs In Animal Manurementioning

confidence: 99%

Environmental Assessment of Tetracycline’s Residues Detected in Pig Slurry and Poultry Manure

Carballo¹,

Aguayo²,

González³

et al. 2016

JEP

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The widespread use of antimicrobials in animal husbandry has led to an increase in concentrations of antibiotics in animal faeces. Furthermore, the spreading of this waste as fertilizer on agricultural land indirectly introduces antimicrobial residues into the environment. This study examined samples of pig slurry and poultry manure for three tetracyclines-oxytetracycline (OTC), chlortetracycline (CTC) and doxycycline (DOC) and conducted an environmental evaluation of soils. The samples were taken from manure heaps on eight broiler chicken farms and from slurry ponds on eight pig farms. The tetracycline analysis was conducted using high-performance liquid chromatography combined with tandem mass spectrometry (HPLC/MS). The risk assessment was carried out on the basis of the estimated PECsoil value and the ecotoxicological information available for terrestrial organisms. TC concentrations were between >0.01 and 1.38 mg/kg. OCT was detected in 37% of the poultry manure and in 20% of the pig slurry samples. DOC was present in 50% of pig slurry samples with an average concentration of 1.2 mg/kg, while CTC was only found in one slurry sample at a concentration of 0.56 mg/kg. Compared with published values for these two farm animals from other countries, the TC concentrations obtained in this study were low. The environmental importance of the data generated was also discussed.

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“…They reduce the harmful effects of reactive oxygen species (ROS) and other free radicals, competing for active sites and receptors in diverse cellular structures. Furthermore, they modulate the expression of genes involved in intracellular defense mechanisms against degenerative oxidative processes of cellular structures (Bastos et al, 2009, Sikoraet al, 2008, Wen et al, 2012. Maize (Zea mays L.) is a crop of major socioeconomic importance around the world.…”

Section: Introductionmentioning

confidence: 99%

February 2020

2020

Aust J Crop Sci

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Biofortification and bioactive compounds enrichment of maize genotypes is a great alternative for mitigating micronutrients deficiency in human and animal diet, and also for improving the benefits of maize for human health. This work aimed to estimate variance components and genetic parameters of bioactive compounds and micronutrients to predict superior maize hybrids from different genetic bases, and to apply the RELM/BLUP methodology to multivariate techniques. The inbreed lines were crossed and the F1 hybrids were grown for evaluations in 2014/2015 and 2015/2016 growing seasons, respectively. Then, micronutrients and bioactive compounds related traits were evaluated. The variance components and genetic parameters were estimated by REML methodology. The BLUP methodology was employed to predict genetic values and to verify the percentages of genetic gain with selection. The predicted genetic values were applied to estimate genetic distances by the Mean Euclidean Distance. The relative contribution of each trait to genetic divergence was evaluated and the principal components analysis determined, proposing the genotypes that are potentially capable to increase a given trait. The presence of genetic variability was evidenced among genotypes, while some of them presented potential for increasing specific traits. The top cross hybrid L64XAS1590 showed the highest estimates for increasing antioxidant-responsible traits, and micronutrients contents such as manganese, cooper, iron and zinc. In general, there was the possibility of achieving genetic gains with selection under application of biofortified and bioactive compounds to enhance maize hybrids through conventional breeding. However, it does not applicable for iron content due to its low estimate of broad sense heritability.

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Toxic effects of chlortetracycline on maize growth, reactive oxygen species generation and the antioxidant response

Cited by 29 publications

References 28 publications

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Environmental Assessment of Tetracycline’s Residues Detected in Pig Slurry and Poultry Manure

February 2020

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