Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats

Lafuente, A.; González-Carracedo, A.; Romero, Alejandro; Cabaleiro, Teresa; Esquifino, Ana I.

doi:10.1016/j.toxlet.2004.08.011

Cited by 43 publications

(38 citation statements)

References 30 publications

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“…The results indicate that the inherent transcription, translation, and post-translational modifications that give the clock its own natural rhythmicity (Ramsey et al 2007) is disrupted in rats drinking a low amount of CdCl 2 in tap water. Previous studies form this laboratory indicated that chronic exposure of rats to low doses of Cd affected significantly the circadian variation of pituitary hormone release (Lafuente et al 2003(Lafuente et al , 2004(Lafuente et al , 2005. Presumably, the changes in clock gene expression in MBH, a key region in hormone regulation, play a role in the circadian hormone disruption.…”

Section: Discussionmentioning

confidence: 93%

“…According to WHO (Wakabayashi et al 1987) one cigarette (containing 0.5-3 lg Cd per gram of tobacco) can result in up to 3 lg daily Cd absorption via the lungs. Chronic exposure to these low doses of Cd causes neuroendocrine and neurobehavioral disturbances in animals and humans (Viaene et al 2000;Lafuente et al 2003Lafuente et al , 2004Lafuente et al , 2005Leret et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus

et al. 2010

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The effect of cadmium (Cd) in the brain has been attributed to an increase in reactive oxygen species in cells, particularly when high amounts of the metal are given. In this study we examined the effect of a low dose of Cd (7.5 microg/day) on 24-h changes in expression of redox pathway enzyme and circadian genes in rat medial basal hypothalamus (MBH). Rats receiving CdCl(2) (5 ppm in drinking water) or tap water for 1 month were killed at six different time intervals throughout a 24 h cycle. MBH mRNA levels were measured by real-time PCR analysis. In CdCl(2) treated rats a disruption of 24-h pattern of hypothalamic gene expression of nitric oxide synthase (NOS)-1 and -2, heme oxygenase (HO)-1 and -2, Mn- superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase was detectable. Mean levels of MBH mRNA for HO-2, Mn-SOD and catalase augmented after Cd intake, whereas those of NOS-2 decreased. After CdCl(2) intake rats the 24-h pattern of clock gene expression in MBH seen in controls was significantly suppressed (Bmal1) or changed in phase (Per1, Per2, Cry2) while in the case of Clock significant 24-h variations were induced. The results are compatible with the view that a low amount of Cd given in tap water brought about significant changes in circadian expression of redox enzyme and clock genes in rat MBH.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus

et al. 2010

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“…By choosing PND 15 for the last day of the experiment, we wanted to exclude the intake of any solid food by the pups (supplied to mother rats in the cage), which we noticed to occur in the late preweaning period (weaning at PND 21). The mean daily dose of Cd given to pups was in the range of those ingested by adult rats chronically exposed to 5-25 ppm of Cd in drinking water (Brzóska and Moniuszko-Jakoniuk 2005;Lafuente et al 2005;Rogalska et al 2009). According to Brzóska and Moniuszko-Jakoniuk (2005) treatment with these doses reflects real exposure level in moderately to heavily polluted areas, in active tobacco smokers or under occupational exposure conditions.…”

Section: Resultsmentioning

confidence: 99%

The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats

et al. 2009

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Selenium (Se) reduces cadmium (Cd) toxicity in adult animals, but its effects in newborn animals are still unknown. This study investigated Cd (as CdCl2) absorption, distribution, and retention in suckling rats receiving oral Se supplementation (as Na2SeO3) in equimolar doses (8 μmol Cd and/or Se per kg b.w./day). Selenium was given either before and during Cd exposure (Sepre + Cd group; pretreatment group) or only during Cd exposure (Se + Cd group). Rats were treated from postnatal day (PND) 6-14 as follows: controls (H2O, PND 6-14), Se (PND 10-14), Cd (PND 10-14), Sepre + Cd (Se PND 6-14 + Cd PND 10-14) and Se + Cd (Se + Cd PND 10-14). Selenium supplementation, especially pre-treatment, decreased Cd levels in the blood, brain, liver and kidney of suckling rats. Selenium levels in plasma, brain, and kidney also decreased. These findings suggest that higher Se intake could efficiently reduce Cd retention during the suckling period.

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“…Bhalla et al (2007) reported that orally administered Zn did not cause a significant alteration in serotonin concentration. Lafuente et al (2005) reported that rats exposed to Cd had no change in 5-HT concentration in the median eminence, although it increased in both the anterior and posterior pituitary.…”

Section: Discussionmentioning

confidence: 99%

“…These results support the theory that Zn supplementation can reduce the suppressive effect exerted by heavy metals on dopamine synthesis. Cd and Pb can cross the blood-brain barrier and reduce the concentrations of this amine (Lafuente et al, 2005;Romero et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Preventive action of zinc against heavy metals toxicity in honeybee

Nisbet¹,

Güler²,

OrmancÄ³

et al. 2018

Afr. J. Biochem. Res.

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A detrimental consequence of industrial growth has been the steady increase in heavy metal pollution which has major, negative impacts on living organisms. Heavy metals still pose a significant health threat, despite the implementation of many strategies to reduce pollution. The aim of this study was to investigate the possible effects of zinc on the accumulation of some heavy metals in honeybees. Groups totalling 15 hives of Apis mellifera were included in this study. Group A was fed sugar syrup, Group B was fed sugar syrup with Cu, Cd and Pb, and Group C was fed sugar syrup with Cu, Cd, Pb and Zn. Food stocks, number of mature worker bees, environment and colony management were standardised across the 15 hives. The data demonstrated that the co-administation of zinc to honeybees, exposed to heavy metals reduced Cu and Cd concentration in tissue samples, but had no effect on Pb concentration. Furthermore, Zn dietary supplementation was effective in reducing both the suppression of dopamine production and the negative effects of heavy metals on dopamine. The results of our study suggest that zinc supplementation in the diet of A. mellifera has a beneficial effect by reducing the cellular accumulation of some heavy metals.

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Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats

Cited by 43 publications

References 30 publications

Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus

Effect of cadmium on 24-hour pattern in expression of redox enzyme and clock genes in rat medial basal hypothalamus

The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats

Preventive action of zinc against heavy metals toxicity in honeybee

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