2005
DOI: 10.1016/j.toxlet.2004.08.011
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Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats

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Cited by 43 publications
(38 citation statements)
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“…The results indicate that the inherent transcription, translation, and post-translational modifications that give the clock its own natural rhythmicity (Ramsey et al 2007) is disrupted in rats drinking a low amount of CdCl 2 in tap water. Previous studies form this laboratory indicated that chronic exposure of rats to low doses of Cd affected significantly the circadian variation of pituitary hormone release (Lafuente et al 2003(Lafuente et al , 2004(Lafuente et al , 2005. Presumably, the changes in clock gene expression in MBH, a key region in hormone regulation, play a role in the circadian hormone disruption.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…The results indicate that the inherent transcription, translation, and post-translational modifications that give the clock its own natural rhythmicity (Ramsey et al 2007) is disrupted in rats drinking a low amount of CdCl 2 in tap water. Previous studies form this laboratory indicated that chronic exposure of rats to low doses of Cd affected significantly the circadian variation of pituitary hormone release (Lafuente et al 2003(Lafuente et al , 2004(Lafuente et al , 2005. Presumably, the changes in clock gene expression in MBH, a key region in hormone regulation, play a role in the circadian hormone disruption.…”
Section: Discussionmentioning
confidence: 93%
“…According to WHO (Wakabayashi et al 1987) one cigarette (containing 0.5-3 lg Cd per gram of tobacco) can result in up to 3 lg daily Cd absorption via the lungs. Chronic exposure to these low doses of Cd causes neuroendocrine and neurobehavioral disturbances in animals and humans (Viaene et al 2000;Lafuente et al 2003Lafuente et al , 2004Lafuente et al , 2005Leret et al 2003).…”
Section: Introductionmentioning
confidence: 99%
“…By choosing PND 15 for the last day of the experiment, we wanted to exclude the intake of any solid food by the pups (supplied to mother rats in the cage), which we noticed to occur in the late preweaning period (weaning at PND 21). The mean daily dose of Cd given to pups was in the range of those ingested by adult rats chronically exposed to 5-25 ppm of Cd in drinking water (Brzóska and Moniuszko-Jakoniuk 2005;Lafuente et al 2005;Rogalska et al 2009). According to Brzóska and Moniuszko-Jakoniuk (2005) treatment with these doses reflects real exposure level in moderately to heavily polluted areas, in active tobacco smokers or under occupational exposure conditions.…”
Section: Resultsmentioning
confidence: 99%
“…Bhalla et al (2007) reported that orally administered Zn did not cause a significant alteration in serotonin concentration. Lafuente et al (2005) reported that rats exposed to Cd had no change in 5-HT concentration in the median eminence, although it increased in both the anterior and posterior pituitary.…”
Section: Discussionmentioning
confidence: 99%
“…These results support the theory that Zn supplementation can reduce the suppressive effect exerted by heavy metals on dopamine synthesis. Cd and Pb can cross the blood-brain barrier and reduce the concentrations of this amine (Lafuente et al, 2005;Romero et al, 2011).…”
Section: Discussionmentioning
confidence: 99%