The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats

Lazarus, Maja; Orct, Tatjana; Jurasoviæ, Jasna; Blanuša, Maja

doi:10.1007/s10534-009-9249-9

Cited by 45 publications

(34 citation statements)

References 70 publications

(81 reference statements)

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“…Direct comparison with inorganic Se cannot be made in the present study as it was not used; however, previous work with inorganic Se showed that 0.1 mg/kg Se, as Na 2 SeO 3 , added to diets contained 200 mg/kg of CdCl 2 did not induce any significant changes in the levels of Cd accumulation in rats' kidney, liver (Jihen et al, 2008) and testis (Messaoudi et al, 2010). However, another study showed that inorganic Se supplementation reduced Cd levels in the liver and kidney of rat pups (Lazarus et al, 2009). It is possible that differences regarding reduction or not of Cd accumulation by Se noted between different studies may be related with the administered doses, the mode of application and the duration of exposure.…”

Section: Discussioncontrasting

confidence: 52%

“…The majority of studies examining ways to reduce Cd toxicity with Se were conducted in mammals using inorganic Se (Jihen et al, 2008;Messaoudi et al, 2010). Inorganic Se orally administered to suckling rats, equimolar to Cd, reduced Cd levels in the liver and kidney of the pups (Lazarus et al, 2009). Moreover, organic Se is a highly available form of Se for livestock and provides antioxidant protection at a level greater than inorganic Se (Mahan, 1999;Mahmoud and Edens, 2003).…”

Section: Introductionmentioning

confidence: 99%

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The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Al-Waeli

Zoidis

Pappas

et al. 2013

Animal

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This work was part of a project designed to assess whether organic selenium (Se) can protect against the toxic effects of cadmium (Cd). A total of 300 1-day-old, as hatched, broilers were randomly distributed in four dietary treatments with five replicate pens per treatment. In T1 treatment, broilers were fed a diet with 0.3 mg/kg added Se, as Se-yeast, without added Cd; in T2, broilers were fed a diet with 0.3 mg/kg Se and 10 mg/kg Cd; in T3, broilers were fed a diet with 0.3 mg/kg Se and 100 mg/kg of Cd; and in T4 treatment broilers were fed a diet with 3 mg/kg Se and 100 mg/kg Cd. The Cd was added to diets T2, T3 and T4 as CdCl 2 . On the 4th and 6th week, two broilers per replicate pen were killed in order to obtain whole blood, liver, kidney and breast samples. Body mass, feed conversion ratio and mortality were assessed and haematological analyses were performed. Se and Cd levels in tissues were analysed by inductively coupled plasma mass spectrometry. Broilers supplemented with 0.3 mg/kg Se can tolerate low levels of Cd added to the diets, as there were no significant negative effects on the examined performance parameters, whereas addition of excess Cd led to an impairment of broilers' performance. Mortality of broilers did not differ between the four dietary treatments at any interval point or the whole period. The examined haematological parameters such as haematocrit, total blood protein concentration, and leukocytes types ranged within physiological values, revealing no negative health effects after simultaneous Cd and Se addition. The present study indicated that Se can help against the negative effects of Cd, but cannot counteract all of its negative effects.

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Al-Waeli

Zoidis

Pappas

et al. 2013

Animal

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“…Se is incorporated into proteins to develop selenoproteins, some of which are important antioxidant enzymes, such as glutathione peroxidase (GPx), the enzyme playing central role in antioxidative response of the animal organism. Lazarus et al (2009) observed the effect of Se supplementation of the Cd-exposed suckling rats on GPx activity in brain and kidney of animals. Although not proven by the measurement of the enzymatic activity in this experiment, the engagement of the Se-incorporating enzymes is expectable in this case.…”

Section: Resultsmentioning

confidence: 99%

“…Special attention was paid to the Se interaction with toxic elements, especially Cd. Sasakura and Suzuki (1998) proved complexation mechanisms of Cd with selenoprotein P. Lazarus et al (2009) showed a more substantial decrease in blood Cd and Se in rats exposed to both elements compared to those exposed to them individually. In the rat liver, Cd accumulation decreased in Se-supplemented animals compared to the rats exposed solely to Cd, as well.…”

Section: Introductionmentioning

confidence: 93%

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Myška¹,

Száková²,

Fučíková³

et al. 2016

CZECH J ANIM SCI

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ABSTRACT:The effect of selenium-enriched defatted rapeseeds (DRS) added to the diet on Se uptake by rat organisms (whole blood, liver, kidney) was investigated in model conditions. Additionally, the response of other essential trace and major mineral elements (Cu, Ca, Fe, K, Mg, Mn, P, S, and Zn) in rat organisms on selenium and/or DRS addition was assessed. The experimental diets for the individual experimental groups were prepared as follows: group DRS 0 (control diet), group DRS 30 (30% of soybean meal in the diet replaced with DRS), group DRS60 (60% of soybean meal in the diet replaced with DRS), and group DRS100 (100% of soybean meal in the diet replaced with DRS), either unenriched or naturally fortified with Se. Whereas Se content in the blood and liver of the animals remained unchanged, increased Se levels were observed in kidney of the selenized DRS100 group compared to the others. Moreover, the results showed decreasing Cd content in the rat liver with increasing Se content in the diet, confirming antagonism of these elements. Concerning the essential elements, the application of the selenized DRS did not result in any serious imbalance in the utilization of these elements. In contrast, Se addition seems to be helpful for the improved utilization of essential elements such as P, S, and Zn, compared to the DRS-containing diet without Se fortification.

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“…Перспективним в цьому напрямку є вирощування рослин-накопичувачів Кадмію з метою зниження його рівня в грунті (Grant et аl., 2008). Експериментально було доведено, що здатність до виведення важких металів (у тому числі й кадмію) з тваринного організму мають Селен (El-Sharaky et al, 2007;Lazarus et al, 2009;Pirova et al, 2010), Цинк та Залізо (Alonco et al, 2004), глиноземи та алюмосилікати (Zasekin et al, 2000;Beltcheva et al, 2015), пектиновмісні добавки (Jourdain, 2005;Tarasenko et al, 2006) тощо. Заслуговує також на увагу застосування в годівлі тварин «функціональних кормів» (Banchi et.…”

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Природні Детоксиканти В Раціоні Та Їх Вплив На Продуктивність І Якість Продуктів Забою Свиней На Відгодівлі

et al. 2017

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Among the pollutants one of the main factor is heavy metals. Cadmium, a typical representative of this group has a very toxic effect on both the animal and the human. It is not involved in the vital processes of living organisms. Instead, exceeding the maximum permissible levels of cadmium has negative affects on animal, and accumulation in the tissues, is a threat to human life -the consumer of animal products. The results of research show efficiency of dry apple pulp and dry beet pulp as natural detoxicant of heavy metals, including cadmium, in the body of young pigs. Experimentally proved that the cadmium content in complete feed with the maximum permissible level (1 mg/kg) predetermined decrease of average daily gain of pigs experimental group, compared with the control, by 10.8% and increase of feed conversion by 9.8%. The introduction to the mixed fodder of dry apple pulp (45 g/kg) or dry beet pulp (45 g/kg) with of the same cadmium content contributed that the productivity of animals, the cost of feed for 1 kg of growth, slaughter weight, carcass yield, weight mascara and economic efficiency of fattening young pigs approaching to the level of control. In addition, the use of dry apple pulp and dry beet pulp as natural forage detoxicant in diets of young pigs helps significantly (P <0.05-0.001), reduction of heavy metals, including cadmium in products of slaughter (meat, bacon, liver, kidney, heart), which increases their purity, environmental safety and competitiveness. Key words: pigs; cadmium; forage detoxicants; productivity; slaughter products Природні детоксиканти в раціоні та їх вплив на продуктивність і якість продуктів забою свиней на відгодівлі Л.С. Дяченко, Т.Л. Сивик, О.М. Титарьова, О.А. Кузьменко, В.В. БількевичБілоцерківський національний аграрний університет E-mail: Djachenko@hotmail.comНаведено результати досліджень ефективності використання сухого яблучного і сухого бурякового жому як природних детоксикантів важких металів, зокрема Кадмію, в організмі молодняку свиней на відгодівлі. При цьому встановлено, що вміст Кадмію в повнораціонному комбікормі в межах максимально допустимого рівня (1 мг/кг) спричинював зменшення середньодобового приросту свиней дослідної групи, порівняно з контролем, на 10,8 % та збільшення затрат корму на приріст на 9,8 %. За уведення в комбікорм сухого яблучного жому (45 г/кг) чи сухого бурякового жому (45 г/кг) за такого самого вмісту Кадмію продуктивність тварин, затрати корму на 1 кг приросту, забійна маса, забійний вихід, маса туші та економічна ефективність відгодівлі молодняку свиней наближалися до рівня контролю. Поряд з цим використання сухого яблучного і бурякового жому, як природних кормових детоксикантів у раціонах молодняку свиней на відгодівлі, сприяє вірогідному (р<0,05-0,001), зменшенню накопичення важких металів, зокрема Кадмію, в продуктах забою тварин (м'ясо, шпик, печінка, нирки, серце), що підвищує їх доброякісність, екологічну безпечність і конкурентоздатність.

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The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats

Cited by 45 publications

References 70 publications

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Природні Детоксиканти В Раціоні Та Їх Вплив На Продуктивність І Якість Продуктів Забою Свиней На Відгодівлі

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