Toxic effects and residue of aflatoxin B1 in tilapia (Oreochromis niloticus×O. aureus) during long-term dietary exposure

Deng, Shi-Xi; Liu, Tian; Liu, Fujia; Jin, Sheng-Jie; Liang, Gehao; Yang, Hui‐Jun; Du, Zhen‐Yu; Liu, Yongjian

doi:10.1016/j.aquaculture.2010.07.029

Cited by 160 publications

(161 citation statements)

References 22 publications

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“…However, HSI values significantly decreased in animals exposed to high levels of AFB1 due to the inhibition of lipid mobilization in the adipose tissue. Deng et al (2010) also observed that AFB1 could decrease lipid content in liver lesions which could contribute to the abnormal growth in aflatoxicated livers. Also, the results showed significant decrease in HSI in the fish injected with 6ppm AFB1 which was related to damage in the liver, (a).…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, feeding AFB1 exhibited many pathological changes in the liver of tilapia including infiltration by eosinophilic cells and numerous inflammatory cells (Deng et al, 2010). Tilapia fed 0.05-0.2 mg AFB1/kg diet showed vacuolization with necrosis in the hepatocytes (El-Banna, Teleb, Hadi, & Fakhry, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Aflatoxin B1 causes reduction in body weight, behavioral abnormalities, depressed immune response, necrotic hepatocytes and other unfavorable impacts in aflatoxicated fish (Deng et al, 2010;Farabi,.Yousefian, & Hajimoradloo, 2006). In addition, AFB1 has been shown to cause immunosuppressive, teratogenic and mutagenic effects in laboratory and farm animals (IPCS-WHO, 1998).…”

Section: Introductionmentioning

confidence: 99%

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El‐Barbary¹

2018

Turk. J. Fish. Aquat. Sci.

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Aflatoxin B1 is one of the most important mycotoxins due to its hepatotoxic and carcinogenic effects on some fishes. This study was conducted to investigate the defensive role of curcumin and garlic on phase I of the biotransformation system in the liver of aflatoxicosis in Oreochromis niloticus in relation to the therapeutic properties by studying hepatic histopathology and cytochrome P450-CYP1A gene expression using real-time polymerase chain reaction (RT-PCR). Although varieties of methods have been used for gene expression quantification and are still used today, real-time RT-PCR method has achieved prominence in recent years. One hundred and eighty (180) fish were equally divided into 10 groups. T1 was the negative control; fish in T2 were injected intraperitonealy (IP) with AFB1 at a rate of 6 mg kg -1 B.W. and fed on a basal diet. Groups T3-T6 were fed with garlic (T3 & T4) and curcumin (T5 & T6) at 10 & 20 g kg -1 diet, respectively. Groups T7-T10 injected IP with AFB1 and fed on both garlic and curcumin at the different concentrations (10 & 20 g kg -1 diet). AFB1 reduced the HSI values in aflatoxicosis fish. Feeding a low dose of garlic led to significant improvement in the HSI values. Histologically, hepatic lesions were observed in the AFB1 injected groups; damage was reduced when fish were fed on garlic and curcumin diets at a concentration 10 g kg -1. The highest induction of CYP1A expression was observed in the curcumin groups followed by AFB1. The over expression of CYP1A in T2 was alleviated by the garlic. Therefore, it was found that garlic enhances the detoxification of AFB1 through the suppression of CYP1A in the liver.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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El‐Barbary¹

2018

Turk. J. Fish. Aquat. Sci.

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“…The increasing amount of herbal compounds in fish feed has enhanced chances of feed contamination with toxins, fungi metabolites and mycotoxins [1,2]. The same problem has been reported in varied species of farmed aquaculture [3].…”

Section: Introductionmentioning

confidence: 84%

Evaluation of Nephrotoxic Effects of Aflatoxins on Common Carp (Cyprinus carpio)

Taheri

Banaee

Haghi

et al. 2017

IJT

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“…Deng et al (2010), after evaluating the effect of aflatoxins on the tilapia diet for a period of 20 weeks, did not observe toxic effects when administered at concentrations of 1.6 mg/kg, thus attributing this to good growing conditions. However, El-Sayed and Khalil (2009) demonstrated acute toxic effects and changes in behavior among sea bass (Dicentrarchus labrax L.) fed with aflatoxin at concentrations of 0.018 mg/kg, which were lower than those used in our study.…”

Section: Discussionmentioning

confidence: 99%

Aeromonas hydrophila in tilapia (Oreochromis niloticus) after the intake of aflatoxins

et al. 2013

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) e um grupo controle com ração sem aflatoxina, em um delineamento inteiramente randomizado com quatro tratamentos e cinco repetições. No segundo ensaio, utilizou-se um grupo controle que recebeu ração livre de aflatoxina, o qual foi inoculado com solução salina (grupo 1) e Aeromonas hydrophila (grupo 2), bem como grupos de animais que receberam ração contendo 0,350 mg.kg feed -1 de aflatoxina (grupo 3); 0,757 mg.kg feed -1 de aflatoxina (grupo 4); e 1,177 mg.kg ração -1 de aflatoxina (grupo 5), sendo estes grupos inoculados com Aeromonas hydrophila. A sobrevivência e o comprimento total dos alevinos foram influenciados pelos tratamentos (p < 0,05). A ação sinérgica de aflatoxinas e Aeromonas hydrophila mostrou-se eficaz ao provocar a morte dos alevinos e influenciar a conversão alimentar e comprimento. PALAVRAS-CHAVE:peixe; micotoxina; patógeno oportunista. ABSTRACT:The objectives of this study were to assess the effect of the intake of aflatoxin on the development of tilapia and to evaluate the impact of inoculation with Aeromonas hydrophila on performance parameters, so these two individual tests were performed. One hundred and twenty fingerlings aged 35 days old, with mean weight of 1.55 ± 0.005 g and mean length of 5 cm were used in each test, distributed in 20 tanks. Each experimental unit consisted of a 60 L tank with six fingerlings. In the first experiment, increasing levels of aflatoxin (0.350, 0.757, 1.177 mg.kg feed -1 ) were used as treatments and, for the control group, a diet without aflatoxin was used in a completely randomized design with four treatments and five replicates. In the second experiment, a control group of Nile tilapia fingerlings was used and received a diet without aflatoxin, inoculated with saline solution (group 1) and Aeromonas hydrophila (group 2), as well as groups of animals fed on diets containing 0.350 mg.kg feed -1 of aflatoxin (group 3), 0.757 mg.kg feed -1 of aflatoxin (group 4) and 1.177 mg.kg feed -1 of aflatoxin (group 5), and these groups were inoculated with Aeromonas hydrophila. The survival rate and the total length of fingerlings were influenced by the treatments (p < 0.05). The synergistic action of aflatoxins and Aeromonas hydrophila was effective and caused the death of experimental fish, thus affecting feed conversion and length.

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Toxic effects and residue of aflatoxin B1 in tilapia (Oreochromis niloticus×O. aureus) during long-term dietary exposure

Cited by 160 publications

References 22 publications

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Evaluation of Nephrotoxic Effects of Aflatoxins on Common Carp (Cyprinus carpio)

Aeromonas hydrophila in tilapia (Oreochromis niloticus) after the intake of aflatoxins

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