Toxic drug-induced chronic pruritus

Veña, Gino Antonio; Cassano, Nicoletta

doi:10.3109/08923973.2012.690100

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Cutaneous lesions related to adverse drug reactions (ADRs) are neither specific nor unique for any drug, consisting in a great variety of possible clinical manifestations, such as vasculitis, photosensitivity, erythema multiforme, purpura, bullous eruptions, lupus erythematosus-like lesions, pityriasis rosea-like lesions, urticaria, angioedema, lichenoid rashes, pruritus, exanthemata, eczema and Stevens-Johnson's syndrome [1][2][3][4][5] . Antihypertensive drugs include a heterogeneous group of agents which are widely prescribed and very frequently used in the management of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Eczematous reactions due to angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers

Veña

Cassano

Coco

et al. 2013

Immunopharmacology and Immunotoxicology

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Cutaneous adverse drug reactions (ADRs) to antihypertensive drugs have been frequently reported. We describe a peculiar clinical pattern of cutaneous ADR, represented by an eczematous reaction induced by certain antihypertensive drugs that we observed in elderly patients. The case series consisted of 23 hypertensive patients aged 66-87 years; 19 of them were taking another drug in addition to the suspected antihypertensive medication and 15 were on polytherapy with three or more drugs to treat multiple comorbidities. The antihypertensive culprit agents were angiotensin-converting enzyme (ACE) inhibitors in 9 patients, ACE-inhibitors combined to hydrochlorothiazide (HCT) in 7 subjects, angiotensin II receptor blockers alone in 2 patients and associated with HCT in 5 cases. The cutaneous ADR was characterized by an eczematous rash that was generalized in 16 patients and localized in 7 cases, with predominant involvement of lower limbs. Such lesions developed after a latency of 4-30 months and were associated with moderate-to-severe itch, usually unresponsive to oral antihistamines. Histopathological diagnosis was available for 9 cases, confirming the presence of a spongiotic dermatitis with possible associated psoriasiform skin changes.

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Section: Introductionmentioning

confidence: 99%