Toxic and beneficial effects of carbon nanomaterials on human and animal health

Hassan, Atef A.; Mansour, Mogda K.; Ahl, Rasha M.H. Sayed El; Hamaky, Ahmed M.A. El; Oraby, Noha H.

doi:10.1016/b978-0-12-819786-8.00023-2

Cited by 16 publications

(19 citation statements)

References 117 publications

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“… 1 Research on the antiviral properties of carbon-based nanomaterials is still in its embryonic state. The main interest in these systems lies precisely in their potential low toxicity 3 and innovative virus inhibition mechanisms. The ambition of using nanoscale systems is to combine virostatic properties with virucidal inactivation processes.…”

Section: Introductionmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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Section: Introductionmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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“…Even though the numbers of nanomaterials based clinical trials has grown recently, the CNMs based clinical studies have come across several challenges in terms of approvals for application in patients. This is mainly due to their intrinsic cytotoxicity to all major organs in the body [ 14 , [215] , [216] , [217] , [218] ]. Therefore, in order to develop safe CNM based strategies for cardiovascular repair, the toxic effects of these materials need to be thoroughly investigated.…”

Section: Barrier For Clinical Translation Of Cnmsmentioning

confidence: 99%

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Alagarsamy

Mathan

Yan

et al. 2021

Bioactive Materials

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to “damage-control” rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside.

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“…Carbon nanomaterials have significant antifungal and antimycotoxin potential [ 3 , 5 ]. The carbon atom contents enable the destruction of pathogen cell walls [ 40 ].…”

Section: Nanoantifungals: Diversity and Relevance For Applications In Veterinary Medicinementioning

confidence: 99%

“…The specific fungal disorders include bovine mastitis, fungal diarrhea in calve, respiratory disorders, superficial, subcutaneous, and systemic infections and mycotoxicosis [ 1 , 2 ]. The variability of the extent of serious public health risk effects of fungal infections in livestock and other domesticated animals spans carcinogenic, nephrotoxic, and hepatotoxic effects following their consumption in the contaminated grains/animal food products [ 1 , 3 ]. Animal production holds considerable economic importance for humans, particularly in low-income countries [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further, dual benefits can be reaped through use of nanomaterials for both therapy and diagnosis of disease pathogens separately and for developing conjugate systems for simultaneous diagnosis and targeted release of the therapeutic agent, theragnostic systems [ 9 ]. Moreover, novel nano-based disease diagnosis and therapeutic systems have been developed for effective treatment of different animal diseases caused by fungal, parasitic and viral pathogens [ 3 , 5 ]. The antifungal nanomaterials can be applied for the diagnosis of the problems related to reproductive system of the animals [ 10 ] and for the protection of the physiological activities of animal genital organs and secretions [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

Alghuthaymi

Hassan

Kalia

et al. 2021

JoF

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The global recognition for the potential of nanoproducts and processes in human biomedicine has given impetus for the development of novel strategies for rapid, reliable, and proficient diagnosis, prevention, and control of animal diseases. Nanomaterials exhibit significant antifungal and antimycotoxin activities against mycosis and mycotoxicosis disorders in animals, as evidenced through reports published over the recent decade and more. These nanoantifungals can be potentially utilized for the development of a variety of products of pharmaceutical and biomedical significance including the nano-scale vaccines, adjuvants, anticancer and gene therapy systems, farm disinfectants, animal husbandry, and nutritional products. This review will provide details on the therapeutic and preventative aspects of nanoantifungals against diverse fungal and mycotoxin-related diseases in animals. The predominant mechanisms of action of these nanoantifungals and their potential as antifungal and cytotoxicity-causing agents will also be illustrated. Also, the other theragnostic applications of nanoantifungals in veterinary medicine will be identified.

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Toxic and beneficial effects of carbon nanomaterials on human and animal health

Cited by 16 publications

References 117 publications

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

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