This study of the Inuvialuit Se lement Region (ISR) socio-economic wellbeing used the established indicators framework, which was developed by the Arc c Social Indicators (ASI) project under the auspices of the Arc c Council. The assessment was conducted for the following six domains: health and popula on, material well-being, cultural vitality, closeness to nature, educa on, and fate control. The analysis revealed considerable internal diff erences within the Inuvialuit Se lement Region in Canada's western Arc c, especially between Inuvik and other communi es in the Northwest Territories (NWT). With respect to most indicators, the ISR was be er off than other NWT regions-with the excep on of the capital city Yellowknife (unemployment, engagement in tradi onal ac vi es, land claims status, and fate control)-or close to average (incomes, dependency on government transfers, consump on of country food, and educa on). The ISR fared worse than other NWT regions with respect to language reten on and outmigra on rates. In comparison with Inuit communi es in Nunavut, the ISR had a generally higher level of material well-being, but demonstrated low language reten on, lower consump on of tradi onal food, and inferior fate control status. The analysis shows that although the Inuvialuit Se lement Region appears to have variable levels of socio-economic well-being across most of the six domains, with some posi ve trends, it s ll faces considerable social challenges and has to deal with interregional inequali es. The most important problems revealed in this study are a con nuing gap between the ISR and Yellowknife with respect to material well-being; dispari es among the ISR communi es (Inuvik vs. all other); poten al shortage and leakage of human capital in outlying communi es; and low language reten on compared to other Inuit regions. h ps://doi.