Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Szász, András

doi:10.31487/j.cor.2020.09.07

Cited by 8 publications

(4 citation statements)

References 44 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The immune stimuli and the immunogenic cancer cell-death [ 154 ] are probably a considerable addition to the elongation of the patient’s survival.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

Lee,

Lorant,

Grand

et al. 2023

Cancers

View full text Add to dashboard Cite

The mEHT method uses tissues’ thermal and bioelectromagnetic heterogeneity for the selective mechanisms. The success of the therapy for advanced, relapsed, and metastatic aggressive tumors can only be demonstrated by measuring survival time and quality of life (QoL). The complication is that mEHT-treated patients cannot be curatively treated any longer with “gold standards”, where the permanent progression of the disease, the refractory, relapsing situation, the organ failure, the worsening of blood counts, etc., block them. Collecting a cohort of these patients is frequently impossible. Only an intent-to-treat (ITT) patient group was available. Due to the above limitations, many studies have single-arm data collection. The Phase III trial of advanced cervix tumors subgrouping of HIV-negative and -positive patients showed the stable efficacy of mEHT in all patients’ subgroups. The single-arm represents lower-level evidence, which can be improved by comparing the survival data of various studies from different institutes. The Kaplan–Meier probability comparison had no significant differences, so pooled data were compared to other methods. Following this approach, we demonstrate the feasibility and superiority of mEHT in the cases of glioblastoma multiform, pancreas carcinomas, lung tumors, and colorectal tumors.

show abstract

“…The immune stimuli and the immunogenic cancer cell-death [ 154 ] are probably a considerable addition to the elongation of the patient’s survival.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

Lee,

Lorant,

Grand

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…Immunogenic cell death is one of the main advantages of mEHT [196], which produces damage-associated molecular pattern (DAMP) [197] by extrinsic excitation of apoptotic pathways through various channels, including the TRAIL-R2 (DR5) death receptors [198] with the complex interaction of FAD + FASS molecules [41] [199]. The concomitant immune-stimulative treatments with dendritic cells [33] [66] and another stimulator [200], with the applied bioelectromagnetic forces by modulated RF signal [19] [44] [45] [201], improve the immunogenic processes.…”

Section: Immune Effectsmentioning

confidence: 99%

The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia

Szász,

Lóránt,

Szász

et al. 2023

OJBIPHY

View full text Add to dashboard Cite

Hyperthermia in oncology is an emerging complementary therapy. The clinical results depend on multiple conditional factors, like the type of cancer, the stage, the applied treatment device, and the complementary conventional therapy. The molecular effect could also be different depending on the temperature, heating dose, kind of energy transfer, and timing sequences compared to the concomitant treatment. This article examines the molecular impacts of a specific technique used in oncological hyperthermia called modulated electro-hyperthermia (mEHT). What sets mEHT apart is its emphasis on harnessing the combined effects of thermal and nonthermal factors. Nonthermal energy absorption occurs through the excitation of molecules, while the thermal component ensures the ideal conditions for this process. The applied radiofrequency current selects the malignant cells, and the modulation drives the nonthermal effects to immunogenic cell death, helping to develop tumor-specific antitumoral immune reactions. The synergy of the thermal and nonthermal components excites the lipid-assembled clusters of transmembrane proteins (membrane rafts) as the channels of transient receptor potentials (TRPs), the heat-shock proteins (HSPs), the voltage-gated channels, and the voltage-sensitive phosphatases (VSPs). All these transmembrane compartments channeling various ionic species (like calcium and proton) interact with the cytoskeleton and are involved in the apoptotic signal pathways.

show abstract

“…An important observation of the modulated treatment is the immunogenic hyperthermic action [155], which can be improved by the independent stimuli of the immune system by dendritic cell therapy [156] [157], or viral therapy [158].…”

Section: Efferent Hepatic Vagus Activity Has Anti-inflammatory Effect...mentioning

confidence: 99%

Stimulation and Control of Homeostasis

Szász¹

2022

OJBIPHY

Self Cite

View full text Add to dashboard Cite

Healthy homeostasis is a principal driving force of the dynamic equilibrium of living organisms. The dynamical basis of homeostasis is the complex and interconnected feedback mechanisms, which are fundamentally governed by the nervous system, mainly the balance of the sympathetic and parasympathetic controlling actions. The balancing regulation is well presented in the heart's sinus node and can be measured by the time-domain heart-rate variation (HRV) of its frequency domain to analyze the constitutional frequencies of the variation. This last is a fluctuation that shows 1/f time fractal arrangement (f is the composing frequency). The time-fractal arrangement could depend on the structural fractal of the His-Purkinje system of the heart and personally modify the HRV. The cancers gradually destroy the homeostatic harmony, starting locally and finishing systemically. The controlling activity of vagus-nerve changes the HRV or the power density spectrum of the signal fluctuations in malignant development, presenting an appropriate control of the cancerous processes. The modified spectrum by a non-invasive radiofrequency treatment could arrest the tumor growth. An appropriate modulation could support the homeostatic control and force reconstructing of the broken complexity.

show abstract

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Cited by 8 publications

References 44 publications

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia

Stimulation and Control of Homeostasis

Contact Info

Product

Resources

About