Towards the development of a miniaturized fiberless optofluidic biosensor for glucose

Cocovi-Solberg, David J.; Miró, Manuel; Cerdà, Vı́ctor; Pokrzywnicka, Marta; Tymecki, Łukasz; Koncki, Robert

doi:10.1016/j.talanta.2011.11.021

Cited by 27 publications

(10 citation statements)

References 48 publications

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“…If the signal is detected by a photodetector, detection limits of 50 mM and less for glucose have been shown feasible Cocovi-Solberg et al, 2012). When the signal is read out by eye, a detection limit of 0.5 mM for glucose is feasible (Dungchai et al, 2010).…”

Section: Characteristics and Performancementioning

confidence: 99%

Microfluidic enzymatic biosensing systems: A review

Mross

Pierrat

Zimmermann

et al. 2015

Biosensors and Bioelectronics

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Section: Characteristics and Performancementioning

confidence: 99%

Microfluidic enzymatic biosensing systems: A review

Mross

Pierrat

Zimmermann

et al. 2015

Biosensors and Bioelectronics

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“…Subsequently, and in line with the above, publications in the bio-sensing field began to emerge. Examples include sweat [15][16][17], hemoglobin [18], human serum [19][20][21], proteins [22,23], glucose [24], dissolved organic substances [25], creatinine in physiological fluids [20], urine [26][27][28], liver function screening [29] and saliva [30].…”

Section: Introductionmentioning

confidence: 99%

LED PEDD Discharge Photometry: Effects of Software Driven Measurements for Sensing Applications

Fay

Nattestad

2022

Sensors

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This work explores the effects of embedded software-driven measurements on a sensory target when using a LED as a photodetector. Water turbidity is used as the sensory target in this study to explore these effects using a practical and important water quality parameter. Impacts on turbidity measurements are examined by adopting the Paired Emitter Detector Diode (PEDD) capacitive discharge technique and comparing common embedded software/firmware implementations. The findings show that the chosen software method can (a) affect the detection performance by up to 67%, (b) result in a variable sampling frequency/period, and (c) lead to an disagreement of the photo capacitance by up to 23%. Optimized code is offered to correct for these issues and its effectiveness is shown through comparative analyses, with the disagreement reduced significantly from 23% to 0.18%. Overall, this work demonstrates that the embedded software is a key and critical factor for PEDD capacitive discharge measurements and must be considered carefully for future measurements in sensor related studies.

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“…In this regard, the non-invasive on-chip characterization of biological and chemical responses by UV-Vis spectrophotometry has led to numerous PhLoC and optofluidic sensors [19,20]. These systems have been proposed for a wide range of applications, from cell culturing and cell analysis [21,22,23,24] to heavy metal ion detection [25,26], enzymatic catalysis for different applications [27,28], and protein concentration measurements [29]. More particularly, this technology can be of special interest to investigate reactions involving radioactive elements, (e.g., for nucleation studies [30], mass transfer [31], etc.).…”

Section: Introductionmentioning

confidence: 99%

Innovative High-Throughput SAXS Methodologies Based on Photonic Lab-on-a-Chip Sensors: Application to Macromolecular Studies

Rodríguez-Ruiz

Radajewski

Charton

et al. 2017

Sensors

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The relevance of coupling droplet-based Photonic Lab-on-a-Chip (PhLoC) platforms and Small-Angle X-Ray Scattering (SAXS) technique is here highlighted for the performance of high throughput investigations, related to the study of protein macromolecular interactions. With this configuration, minute amounts of sample are required to obtain reliable statistical data. The PhLoC platforms presented in this work are designed to allow and control an effective mixing of precise amounts of proteins, crystallization reagents and buffer in nanoliter volumes, and the subsequent generation of nanodroplets by means of a two-phase flow. Spectrophotometric sensing permits a fine control on droplet generation frequency and stability as well as on concentration conditions, and finally the droplet flow is synchronized to perform synchrotron radiation SAXS measurements in individual droplets (each one acting as an isolated microreactor) to probe protein interactions. With this configuration, droplet physic-chemical conditions can be reproducibly and finely tuned, and monitored without cross-contamination, allowing for the screening of a substantial number of saturation conditions with a small amount of biological material. The setup was tested and validated using lysozyme as a model of study. By means of SAXS experiments, the proteins gyration radius and structure envelope were calculated as a function of protein concentration. The obtained values were found to be in good agreement with previously reported data, but with a dramatic reduction of sample volume requirements compared to studies reported in the literature.

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Towards the development of a miniaturized fiberless optofluidic biosensor for glucose

Cited by 27 publications

References 48 publications

Microfluidic enzymatic biosensing systems: A review

Microfluidic enzymatic biosensing systems: A review

LED PEDD Discharge Photometry: Effects of Software Driven Measurements for Sensing Applications

Innovative High-Throughput SAXS Methodologies Based on Photonic Lab-on-a-Chip Sensors: Application to Macromolecular Studies

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