Towards Integration of Biorefinery and Microbial Amino Acid Production

Marx, Achim; Wendisch, Volker F.; Kelle, Ralf; Buchholz, Stefan

doi:10.1002/9783527619849.ch23

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Recently, Marx et al (2005) and also Thomsen (2005) proposed an integration of biorefinery and microbial amino acid production. Biorefineries are referred to as a new manufacturing concept for conversion of renewable biomass to multiple products including fuels and (high-value) chemicals (Kamm and Kamm, 2004;Ragauskas et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Dual transcriptional control of the acetaldehyde dehydrogenase gene ald of Corynebacterium glutamicum by RamA and RamB

Auchter

Arndt

Eikmanns

2009

Journal of Biotechnology

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Section: Discussionmentioning

confidence: 99%

Dual transcriptional control of the acetaldehyde dehydrogenase gene ald of Corynebacterium glutamicum by RamA and RamB

Auchter

Arndt

Eikmanns

2009

Journal of Biotechnology

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“…Currently, there are no ISPR techniques developed in the literature for the extraction of 3‐HP. However, it is thought that processes which proved to be effective for the extraction of short chains carboxylic acids may apply to 3‐HP. Several techniques have been investigated for the recovery of 2‐hydroxypropionic acid (2‐HP), also known as lactic acid, a positional isomer of 3‐HP, including solvent extraction, precipitation, electrodialysis, adsorption by ion exchange resins, aqueous two phase system, etc .…”

Section: Introductionmentioning

confidence: 99%

Reactive extraction of 3-hydroxypropionic acid from model aqueous solutions and real bioconversion media. Comparison with its isomer 2-hydroxypropionic (lactic) acid

Moussa

Burgé

Chemarin

et al. 2015

J. Chem. Technol. Biotechnol.

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BACKGROUND: Bioconversion is a promising route to produce bio-based building blocks such as 3-hydroxypropionic acid (3-HP). Reactive extraction can be used for 3-HP recovery, and ultimately integrated to the bioconversion process. To the best of our knowledge, there is no published experimental data about the reactive extraction of 3-HP. This work aimed to study the extraction of 3-HP using tri-n-octylamine and Aliquat 336 as extractants in n-decanol. Comparison was also made with its positional isomer, lactic acid. Finally, the extraction of 3-HP from model and real bioconversion broths was examined.

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“…Recently, Marx et al [2006] and also Thomsen [2005] proposed an integration of biorefinery and microbial amino acid production. Biorefineries are referred to as a new manufacturing concept for conversion of renewable biomass to multiple products including fuels and (high-value) chemicals [e.g., Kamm and Kamm, 2004;Ragauskas et al, 2006].…”

Section: Introductionmentioning

confidence: 99%

Ethanol Catabolism in <i>Corynebacterium glutamicum</i>

et al. 2007

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Corynebacterium glutamicum grows on a variety of carbohydrates and organic acids as single or combined sources of carbon and energy. Here we show the ability of C. glutamicum to grow on ethanol with growth rates up to 0.24 h^–1 and biomass yields up to 0.47 g dry weight (g ethanol)^–1. Mutants of C. glutamicum deficient in phosphotransacetylase (PTA), isocitrate lyase (ICL) and malate synthase (MS) were unable to grow on ethanol, indicating that acetate activation and the glyoxylate cycle are essential for utilization of this substrate. In accordance, the expression profile of ethanol-grown C. glutamicum cells compared to that of glucose-grown cells revealed an increased expression of genes encoding acetate kinase (AK), PTA, ICL and MS. Furthermore, the specific activities of these four enzymes as well as those of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) were found to be high in ethanol-grown and low in glucose-grown cells. Growth of C. glutamicum on a mixture of glucose and ethanol led to a biphasic growth behavior, which was due to the sequential utilization of glucose before ethanol. Accordingly, the specific activities of ADH, ALDH, AK, PTA, ICL and MS in cells grown in medium containing both substrates were as low as in glucose-grown cells in the first growth phase, but increased 5- to 100-fold during the second growth phase. The results indicate that ethanol catabolism in C. glutamicum is subject to carbon source-dependent regulation, i.e., to a carbon catabolite control.

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Towards Integration of Biorefinery and Microbial Amino Acid Production

Cited by 4 publications

References 35 publications

Dual transcriptional control of the acetaldehyde dehydrogenase gene ald of Corynebacterium glutamicum by RamA and RamB

Dual transcriptional control of the acetaldehyde dehydrogenase gene ald of Corynebacterium glutamicum by RamA and RamB

Reactive extraction of 3-hydroxypropionic acid from model aqueous solutions and real bioconversion media. Comparison with its isomer 2-hydroxypropionic (lactic) acid

Ethanol Catabolism in <i>Corynebacterium glutamicum</i>

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