Towards further understanding of the co-morbidity between attention deficit hyperactivity disorder and bipolar disorder: a MRI study of brain volumes

Abstract

Our results support the hypothesis that ADHD and BPD independently contribute to volumetric alterations of selective and distinct brain structures. In the co-morbid state of ADHD plus BPD, the profile of brain volumetric abnormalities consists of structures that are altered in both disorders individually. Attention to co-morbidity is necessary to help clarify the heterogeneous neuroanatomy of both BPD and ADHD.

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

“…Studies that have compared the morphometric characteristics of the caudate in adults with ADHD 26,27 have found no differences between healthy controls and ADHD patients. In contrast, we found significant differences.…”

“…The studies by Biederman and colleagues 27 and Siedman and colleagues 26 used the same image analysis method developed by This approach includes the selection of region of interest by the user and may produce somewhat imprecise anatomic validity. 39 However, the reliability of VBM is uncertain.…”

“…20,22,23 There have been 4 structural MRI reports regarding morphologic abnormalities in adults with ADHD. [24][25][26][27] Two studies did not report an analysis of the subcortical structures, 24,25 and the other 2 studies 26,27 reported that there was no difference in the volume of the caudate nucleus between adults with ADHD and healthy individuals.…”

Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

“…Structural neuroimaging findings regarding the amygdala are markedly heterogeneous, with findings of decreased, [5][6][7][8] unchanged, [9][10][11][12][13] as well as increased [14][15][16][17][18] amygdala volumes in patients with BD relative to control subjects. Similarly, the literature regarding hippocampal volumes is inconsistent with most studies reporting lack of hippocampal volume changes, 7,[14][15][16] but also with findings of decreased 10 as well as increased 5,19 hippocampal volumes in patients with BD.…”

Trouble bipolaire et trouble déficit d’attention avec hyperactivité

“…Cependant, il n'y a pas de travaux chez l'adulte qui aient directement comparé ces deux populations. En revanche, Rucklidge et al [13] Certains résultats en neuro-imagerie structurale supportent cette hypothèse : des anomalies des structures sous-corticales limbiques (nucleus accumbens) concerneraient plus spécifiquement le TB, tandis que des perturbations des ganglions de la base seraient plus spécifiques du TDAH [2,8]. Ces deux études, en revanche, ne concordent pas sur la nature des anomalies morphométriques des patients comorbides : dans l'étude de Biederman et al [2], le pattern d'anomalies observées résulte clairement de l'association des anomalies observées individuellement dans chacune des deux pathologies, tandis que dans l'étude de Lopez-Larson et al [8], les sujets avec double diagnostic sont très proches des bipolaires sans TDAH associé.…”