Towards FAIR nanosafety data

Jeliazkova, Nina; Apostolova, Margarita D.; Andreoli, Cristina; Barone, Flavia; Barrick, Andrew; Battistelli, Chiara Laura; Bossa, Cecilia; Botea‐Petcu, Alina; Châtel, Amélie; Angelis, De; Dušinská, Maria; Yamani, Naouale El; Gheorghe, Daniela; Giusti, Anna Maria; Gómez-Fernández, Paloma; Grafström, Roland C.; Gromelski, Maciej; Jacobsen, Nicklas Raun; Jeliazkov, Vedrin; Jensen, Keld Alstrup; Kochev, Nikolay; Kohonen, Pekka; Manier, Nicolas; Mariussen, Espen; Mech, Agnieszka; Navas, José M.; Paskaleva, Vesselina; Precupaş, Aurica; Puzyn, Tomasz; Rasmussen, Kirsten; Ritchie, Peter; Llopis, Isabel Rodríguez; Rundén-Pran, Elise; Sandu, Romică; Shandilya, Neeraj; Tănăsescu, Speranţa; Haase, Andrea; Nymark, Penny

doi:10.1038/s41565-021-00911-6

Cited by 84 publications

(85 citation statements)

References 46 publications

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“…Jeliazkova et al [ 49 ] provide a detailed description of the eNanoMapper interface, the data included within and the path towards FAIRifying data (challenges and recommendations). The authors stress the lack of structured data available for re-use purposes and the need for user-friendly reporting formats, complete metadata description, ontology IDs and a harmonized terminology.…”

Section: Discussionmentioning

confidence: 99%

“…The eNanoMapper database provides a FAIR-aligned Nanosafety Data Interface ( https://search.data.enanomapper.net/ (accessed on 5 June 2021)), with an aggregated search application to find data across diverse database instances [49]. The NanoReg2 database, included in eNanoMapper, is freely available and includes twelve datasets comprising of occupational exposure data derived from the Nano Exposure and Contextual Information Database (NECID) (https://perosh.eu/repository/necid-demo-version/ (accessed on 5 June 2021)) database.…”

Section: Comparison With the Enanomapper And Necid Databasementioning

confidence: 99%

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Data Shepherding in Nanotechnology. The Exposure Field Campaign Template

et al. 2021

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In this paper, we demonstrate the realization process of a pragmatic approach on developing a template for capturing field monitoring data in nanomanufacturing processes. The template serves the fundamental principles which make data scientifically Findable, Accessible, Interoperable and Reusable (FAIR principles), as well as encouraging individuals to reuse it. In our case, the data shepherds’ (the guider of data) template creation workflow consists of the following steps: (1) Identify relevant stakeholders, (2) Distribute questionnaires to capture a general description of the data to be generated, (3) Understand the needs and requirements of each stakeholder, (4) Interactive simple communication with the stakeholders for variables/descriptors selection, and (5) Design of the template and annotation of descriptors. We provide an annotated template for capturing exposure field campaign monitoring data, and increase their interoperability, while comparing it with existing templates. This paper enables the data creators of exposure field campaign data to store data in a FAIR way and helps the scientific community, such as data shepherds, by avoiding extensive steps for template creation and by utilizing the pragmatic structure and/or the template proposed herein, in the case of a nanotechnology project (Anticipating Safety Issues at the Design of Nano Product Development, ASINA).

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Section: Discussionmentioning

confidence: 99%

Section: Comparison With the Enanomapper And Necid Databasementioning

confidence: 99%

Data Shepherding in Nanotechnology. The Exposure Field Campaign Template

et al. 2021

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“…Data quality is the heart of science, and many efforts have been made to ensure and improve data quality in other fields such as genetics [ 64 , 65 ], genomics [ 66 , 67 , 68 ], and food science [ 69 ]. According to the recently established FAIR (finable, accessible, interoperable, and reusable) guiding principles, the reuse of nanosafety data involves data quality issues such as different levels of processed data, poorly described (meta)data, and limited harmonized reporting formats and tools for data integration and interpretation [ 70 ]. Notably, these issues are also the technical challenges that scientists face when building a nanomaterial database.…”

Section: Perspectivesmentioning

confidence: 99%

Nanomaterial Databases: Data Sources for Promoting Design and Risk Assessment of Nanomaterials

Guo

Sakkiah

et al. 2021

Nanomaterials

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Nanomaterials have drawn increasing attention due to their tunable and enhanced physicochemical and biological performance compared to their conventional bulk materials. Owing to the rapid expansion of the nano-industry, large amounts of data regarding the synthesis, physicochemical properties, and bioactivities of nanomaterials have been generated. These data are a great asset to the scientific community. However, the data are on diverse aspects of nanomaterials and in different sources and formats. To help utilize these data, various databases on specific information of nanomaterials such as physicochemical characterization, biomedicine, and nano-safety have been developed and made available online. Understanding the structure, function, and available data in these databases is needed for scientists to select appropriate databases and retrieve specific information for research on nanomaterials. However, to our knowledge, there is no study to systematically compare these databases to facilitate their utilization in the field of nanomaterials. Therefore, we reviewed and compared eight widely used databases of nanomaterials, aiming to provide the nanoscience community with valuable information about the specific content and function of these databases. We also discuss the pros and cons of these databases, thus enabling more efficient and convenient utilization.

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“…Exposureomics has revealed the interrelated interactions of physicochemical, human toxicity, ecotoxicological and exposure data (Fan et al 2016;Jeliazkova et al 2021). Aldehydes are common organic compounds produced from a variety of sources, such as e-cigarettes and tobacco smoke, environmental exposure, dietary intake and endogenous intermediary metabolism, to which organisms are frequently exposed (O'Brien et al 2005;Silva et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Dietary Fiber Reduces the Concentrations of Certain Aldehydes in Serum

Shi¹,

Zhu²,

Liao³

et al. 2021

Preprint

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Aldehydes have been shown to be potentially carcinogenic, mutagenic, and cardiotoxic to humans. Dietary fiber reduces exposure to certain environmental pollutants and has been widely used to improve various metabolic disorders. However, the effects of dietary fiber on serum concentrations of aldehydes remain unexplored. We collected data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. Generalized linear regression and restricted cubic spline models were performed to elucidate the association of dietary fiber intake with the serum concentration of aldehydes. After fully adjusting for age, sex, education level, race, smoking status, alcohol use, diabetes, hypertension, body mass index, energy intake, poverty-income ratio and physical activity, dietary fiber intake had a strong negative association with serum levels of isopentanaldehyde and propanaldehyde and a positive association with serum levels of benzaldehyde. The estimated increases in the mean log2-unit (ng/mL) of aldehydes for each fold increase in dietary fiber ranged from − 0.155 (95% confidence intervals [CI]: -0.210 to -0.101) for isopentanaldehyde to -0.053 (95% CI: -0.094 to -0.011) for propanaldehyde and 0.156 (95% CI: 0.091 to 0.222) for benzaldehyde. No significant association was observed between dietary fiber intake and the concentration of any other aldehydes. These results demonstrate that dietary fiber reduces the concentration of certain aldehydes in serum.

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Towards FAIR nanosafety data

Cited by 84 publications

References 46 publications

Data Shepherding in Nanotechnology. The Exposure Field Campaign Template

Data Shepherding in Nanotechnology. The Exposure Field Campaign Template

Nanomaterial Databases: Data Sources for Promoting Design and Risk Assessment of Nanomaterials

Dietary Fiber Reduces the Concentrations of Certain Aldehydes in Serum

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