PurposeThis study seeks to explore the interrelationships between knowledge management and ISO 9001:2000, and details knowledge management and ISO 9001:2000 practices for organizations, according to the prevailing ISO 9001:2000 guidelines and processes.Design/methodology/approachThis study proposes an intact process model that integrates ISO 9001:2000 processes in order to exploit critical knowledge within an organization. A Delphi approach is designed and used to identify activities within this process model, which will facilitate knowledge flow practices. In addition, a knowledge management conceptual framework which integrated ISO 9000 processes, quality information system and infrastructure is proposed. Empirical research, involving a case study with thematic analysis, is presented to discuss the proposed framework.FindingsThis paper identifies the most important activities within ISO 9001:2000 processes which can facilitate knowledge flow. Meanwhile, a comprehensive ISO 9000 process‐based knowledge management system architecture which is derived from the in‐depth interview and the qualitative analyses will be proposed.Research limitations/implicationsThis study is limited in its research methodology. This case study is considered as only one empirical illustration of many other possible implementation processes. It is not assumed that this company is a paradigm or that its specific situation is applicable to all other business enterprises.Originality/valueThis architecture offers an initial model for an organization that wants to facilitate knowledge flows according to the prevailing ISO 9001:2000 guidelines and processes, and further proceed with its knowledge management system implementation to encourage the management of corporate knowledge and effectively enhance the firm's competitiveness.