Towards development of colorimetric test-systems for phenols detection based on computationally-designed molecularly imprinted polymer membranes

Sergeyeva, Т.А.; Gorbach, L.A.; Slinchenko, Olena A.; Honcharova, L.A.; Piletska, O.V.; Brovko, О.O.; Sergeeva, L. M.; Elska, G.V.

doi:10.1016/j.msec.2009.12.012

Cited by 34 publications

(37 citation statements)

References 41 publications

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“…13 Other factors which affect the quality of MIPs include: monomer composition, solvents, polymerisation time, temperature, even the application of a magnetic field. 14 Imprinted polymers can be produced in bulk, in thin film format and as membranes 15 or as a suspension of spherical particles with well-defined size. 16 The high specificity and stability of MIPs renders them promising alternatives to enzymes, antibodies, and natural receptors for use in sensor technology.…”

Section: Natural Biomolecules Mipsmentioning

confidence: 99%

The rational development of molecularly imprinted polymer-based sensors for protein detection

et al. 2011

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The detection of specific proteins, as biomarkers of disease, health status, environmental monitoring, food quality, control of fermenters and civil defence purposes means that biosensors for these targets will become increasing more important. Among the technologies used for building specific recognition properties, molecularly imprinted polymers, molecularly imprinted polymers (MIPs) are attracting much attention. In this critical review we describe many of methods used for imprinting recognition for protein targets in polymers and their incorporation with a number of transducer platforms with the aim of identifying the most promising approaches for the preparation of MIP-based protein sensors.2

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Section: Natural Biomolecules Mipsmentioning

confidence: 99%

The rational development of molecularly imprinted polymer-based sensors for protein detection

et al. 2011

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“…Colorimetric biosensor systems for detection of phenol [93] and creatinine [94] for environmental monitoring and medical diagnostics were developed on the basis of MIP membranes obtained by the methods of in situ and grafting polymerization.…”

Section: Place Of Samplingmentioning

confidence: 99%

Biosensors. A quarter of a century of R&D experience

et al. 2013

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The paper is a review of the researches of Biomolecular Electronics Laboratory concerning the development of biosensors based on electrochemical transducers (amperometric and conductometric electrodes, potentiometric pH-sensitive field effect transistors) and different biorecognition molecules (enzymes, cells, antibodies), biomimics (molecularly imprinted polymers), as sensitive elements for direct analysis of substrates or inhibitory analysis of toxicants. Highly specific, sensitive, simple, fast and cheap detection of different substances renders them as promising tools for needs of health care, environmental control, biotechnology, agriculture and food industries. Diverse biosensor formats for direct determination of different analytes and inhibitory enzyme analysis of a number of toxins have been designed and developed. Improvement of their analytical characteristics may be achieved by using differential mode of measurement, negatively or positively charged additional semipermeable membranes, nanomaterials of different origin, genetically modified enzymes. These approaches have been aimed at increasing the sensitivity, selectivity and stability of the biosensors and extending their dynamic ranges. During the last 25 years more than 50 laboratory prototypes of biosensor systems based on mono- and multibiosensors for direct determination of a variety of metabolites and inhibitory analysis of different toxic substances were created. Some of them were tested in real samples analysis. The advantages and disadvantages of the biosensors developed are discussed. The possibility of their practical application is considere

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“…MIPs for phenol have been prepared by non-covalent imprinting approach in the form of crushed monolith [15], a recognition layer immobilized on silica particles [16], as a membrane [17]. …”

Section: Introductionmentioning

confidence: 99%

Development of Molecularly Imprinted Polymer in Porous Film Format for Binding of Phenol and Alkylphenols from Water

Gryshchenko

Bottaro

2014

IJMS

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Molecularly imprinted polymers (MIPs) were fabricated on glass slides with a “sandwich” technique giving ~20 μm thick films. Methanol/water as a solvent, and polyethyleneglycol and polyvinylacetate as solvent modifiers, were used to give a porous morphology, which was studied with scanning electron microscopy and gravimetric analysis. Various MIPs were synthesized through non-covalent imprinting with phenol as the template; itaconic acid, 4-vinylpyridine, and styrene as monomers; ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, and pentaerythritol triacrylate (PETA) as cross-linkers. Binding and imprinting properties of the MIPs were evaluated based on phenol adsorption isotherms. Since phenol has only one weakly acidic hydroxyl group and lacks unique structural characteristics necessary for binding specificity, the preparation of selective MIPs was challenging. The recognition of phenol via hydrogen bonding is suppressed in water, while hydrophobic interactions, though promoted, are not specific enough for highly-selective phenol recognition. Nevertheless, the styrene-PETA MIP gave modest imprinting effects, which were higher at lower concentrations (Imprinting Factor (IF) = 1.16 at 0.5 mg·L−1). The isotherm was of a Freundlich type over 0.1–40 mg·L−1 and there was broad cross-reactivity towards other structurally similar phenols. This shows that phenol MIPs or simple adsorbents can be developed based on styrene for hydrophobic binding, and PETA to form a tighter, hydrophilic network.

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Towards development of colorimetric test-systems for phenols detection based on computationally-designed molecularly imprinted polymer membranes

Cited by 34 publications

References 41 publications

The rational development of molecularly imprinted polymer-based sensors for protein detection

The rational development of molecularly imprinted polymer-based sensors for protein detection

Biosensors. A quarter of a century of R&D experience

Development of Molecularly Imprinted Polymer in Porous Film Format for Binding of Phenol and Alkylphenols from Water

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