Towards consistency for magnetic resonance (MR) relaxometry of lumbar intervertebral discs

Wáng, Yì-Xiáng J.

doi:10.21037/qims.2016.08.04

Cited by 24 publications

(38 citation statements)

References 24 publications

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“…(IV) To define disc degeneration in vivo, we recommend MRI based methods which provide quantification of biochemical composition of disc tissues, such as T2/T1rho/CEST (54)(55)(56)(57)(58)(59)(60)(61). However, it should be noted that accurate measurement of disc tissues can be challenging (57,(62)(63)(64), and a standard approach for segmenting annuls fibrosis and nucleus pulposus should be considered (64). (V) Ideally, study subjects sample size should be sufficiently large (57) and lumbar disc levels are analyzed individually, as lumbar discs at different levels are under different biomechanical stress (65).…”

mentioning

confidence: 99%

Senile osteoporosis is associated with disc degeneration

Wáng

2018

Quant. Imaging Med. Surg.

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mentioning

confidence: 99%

Senile osteoporosis is associated with disc degeneration

Wáng

2018

Quant. Imaging Med. Surg.

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“…Lumbar disc herniation (LDH) entrapping a nerve root, which leads to lower back and leg pain, is common. Magnetic resonance imaging (MRI), which is often used to diagnose disc herniation, offers considerable information about the location and size of the disc herniation and as well as its mass effect on the nerve roots 1 2 3 . However, inconsistencies between the symptoms and the degree of nerve root compression seen on conventional MRI are continually observed.…”

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confidence: 99%

Microstructural changes are coincident with the improvement of clinical symptoms in surgically treated compressed nerve roots

Wu¹,

Liang²,

Chen³

et al. 2017

Sci Rep

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Diffusion tensor imaging (DTI) has been widely used to visualize peripheral nerves, but the microstructure of compressed nerve roots can be assessed using DTI. However, there are no data regarding the association among microstructural changes evaluated using DTI, the symptoms assessed using the Oswestry Disability Index (ODI) and the duration of symptoms after surgery in patients with lumbar disc herniation (LDH). Thirty patients with unilateral radiculopathy were investigated using DTI. The changes in the mean fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) values as well as the correlation between these changes and the severity and duration of the clinical symptoms were investigated before and at least one month after surgery. The FA values were significantly increased after surgical treatment (p < 0.0001). Both the ADC and ODI values were noticeably decreased (p < 0.0001). A strong positive correlation between the preoperative and postoperative DTI parameters (p < 0.0001) as well as between the preoperative ODI and postoperative ODI/ODI changes (p < 0.0001) were found. In addition, there was a significant positive correlation between the changes in the DTI parameters and changes in the ODI (p < 0.0001). This preliminary study suggests it may be possible to use DTI to diagnose, quantitatively evaluate and follow-up patients with LDH.

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“…This limits its clinical application as does the current lack of validation with a reference standard. 116…”

Section: Disk Volume and Degenerationmentioning

confidence: 99%

Advanced Quantitative Spine Imaging

Griffith¹

2020

Semin Musculoskelet Radiol

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Although advanced quantitative imaging may not be currently used to any degree in the routine reporting of spinal examinations, this situation will change in the not too distant future. Advanced quantitative imaging has already allowed us to understand a great deal more regarding spinal development, marrow physiology, and disease pathogenesis. Radiologists are ideally suited to drive this research forward. To speed up this process and optimize the impact of studies reporting spine quantitative data, we should work toward universal standards on the acquisition of spine data that will allow quantitative studies to be more easily compared, contrasted, and amalgamated.

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Towards consistency for magnetic resonance (MR) relaxometry of lumbar intervertebral discs

Cited by 24 publications

References 24 publications

Senile osteoporosis is associated with disc degeneration

Senile osteoporosis is associated with disc degeneration

Microstructural changes are coincident with the improvement of clinical symptoms in surgically treated compressed nerve roots

Advanced Quantitative Spine Imaging

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