Towards cancer diagnostics – an α-feto protein electrochemical immunosensor on a manganese(<scp>iv</scp>) oxide/gold nanocomposite immobilisation layer

Idris, Azeez O.; Mabuba, Nonhlangabezo; Arotiba, Omotayo A.

doi:10.1039/c8ra06135a

Cited by 13 publications

(4 citation statements)

References 53 publications

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“…The development of biosensing gadgets has also benefited from advancements in bio-recognition components. Traditional biomolecules such as enzymes and antibodies have commonly been used as recognition elements in biosensors [62][63].…”

Section: Advancing Biosensing Technologiesmentioning

confidence: 99%

Exploring the potential of ternary nanocomposite in biosensor development

Olayiwola Idris

2024

Electroanalysis

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Section: Advancing Biosensing Technologiesmentioning

confidence: 99%

Exploring the potential of ternary nanocomposite in biosensor development

Olayiwola Idris

2024

Electroanalysis

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“…The heterojunction formed between g-C 3 N 4 and BiOCl assisted in increasing the photocurrent response of the PEC immunoassay [ 109 ]. We have developed various electrochemical immunosensors for the detection of AFP [ 110 , 111 , 112 ]. In 2019, we developed an exfoliated graphite-based electrochemical immunosensor on a dendrimer/carbon nanodot platform to detect the carcinoembryonic antigen (CEA) cancer biomarker [ 113 ].…”

Section: Multifunctional Applications Of Graphitic Carbon Nitride mentioning

confidence: 99%

Graphitic Carbon Nitride: A Highly Electroactive Nanomaterial for Environmental and Clinical Sensing

Idris

Oseghe

Msagati

et al. 2020

Sensors

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Graphitic carbon nitride (g-C3N4) is a two-dimensional conjugated polymer that has attracted the interest of researchers and industrial communities owing to its outstanding analytical merits such as low-cost synthesis, high stability, unique electronic properties, catalytic ability, high quantum yield, nontoxicity, metal-free, low bandgap energy, and electron-rich properties. Notably, graphitic carbon nitride (g-C3N4) is the most stable allotrope of carbon nitrides. It has been explored in various analytical fields due to its excellent biocompatibility properties, including ease of surface functionalization and hydrogen-bonding. Graphitic carbon nitride (g-C3N4) acts as a nanomediator and serves as an immobilization layer to detect various biomolecules. Numerous reports have been presented in the literature on applying graphitic carbon nitride (g-C3N4) for the construction of electrochemical sensors and biosensors. Different electrochemical techniques such as cyclic voltammetry, electrochemiluminescence, electrochemical impedance spectroscopy, square wave anodic stripping voltammetry, and amperometry techniques have been extensively used for the detection of biologic molecules and heavy metals, with high sensitivity and good selectivity. For this reason, the leading drive of this review is to stress the importance of employing graphitic carbon nitride (g-C3N4) for the fabrication of electrochemical sensors and biosensors.

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“…Sometimes, the nanomaterials are not even incorporated into the sensor development but to obtain a low detection limit, nanomaterials are incorporated in the sensor fabrication processes. Electrochemical approaches have provided novel opportunities for the detection of biological molecules [21][22][23][24], illegal substances, heavy metals [20,25], and organic pollutants [26,27]. This method can also take advantage of smart nanomaterials, which allow for quicker electron transit, better conductivity, and quantum effects to improve sensitivity and selectivity within complicated matrices [28,29].…”

Section: Introductionmentioning

confidence: 99%

A Review on Monitoring of Organic Pollutants in Wastewater Using Electrochemical Approach

et al. 2023

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This review focuses on monitoring selected organic contaminants utilising an electrochemistry technique due to intrinsic benefits such as simplicity, portability, cost, and improved sensitivity. Because the presence of organic pollutants in water causes a variety of health issues such as tumour, headaches, tiredness, and developmental abnormalities, it is critical to explore an effective approach to quantifying these contaminants in various matrices. Although remarkable results have been documented in the use of conventional techniques in the quantification of organic pollutants, owing to high costs, longer pre-concentration steps and analysis times, high power consumption, and the need for sophisticated skilled personnel, their applications for monitoring organic pollutants on-site have been hampered. The electrochemistry approach has emerged to address the difficulties that have hindered the use of traditional approaches for quantifying organic contaminants in water. Thus, the purpose of this review is to examine the concept of employing electrochemistry techniques to determine organic contaminants in various matrixes, and various recommendations for future research have been highlighted. Graphical Abstract This diagram illustrates the steps involved in creating a sensor utilising nanomaterial and connected to a three-electrode system. The nanomaterial is immobilised onto the surface of the working electrode. A suitable potentiostat is then employed to generate the current signal of the reaction between the sensor and the desired analyte.

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Towards cancer diagnostics – an α-feto protein electrochemical immunosensor on a manganese(iv) oxide/gold nanocomposite immobilisation layer

Abstract: A novel electrochemical immunosensor for the quantification of α-feto protein (AFP) using a nanocomposite of manganese(iv) oxide nanorods (MnO2NRs) and gold nanoparticles (AuNPs) as the immobilisation layer is presented.

Cited by 13 publications

References 53 publications

Exploring the potential of ternary nanocomposite in biosensor development

Exploring the potential of ternary nanocomposite in biosensor development

Graphitic Carbon Nitride: A Highly Electroactive Nanomaterial for Environmental and Clinical Sensing

A Review on Monitoring of Organic Pollutants in Wastewater Using Electrochemical Approach

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