Towards calixarene-based prodrugs: Drug release and antibacterial behaviour of a water-soluble nalidixic acid/calix[4]arene ester adduct

Applications of calixarene nano-baskets in pharmacology

“…Thus, researchers are developing the synthetic strategies leading to a water-soluble analogue via introduction of hydrophilic groups at the upper and lower rims of the calixarene scaffold. Dibama et al [51] synthesized a water-soluble calixarene bearing the nalidixic acid, a quinolone antibiotic, and examined its prodrug behavior in vitro by high performance liquid chromatography. Figure 8 presents the chemical structure of the synthetic prodrug.…”

“…8 Chemical structure of a calix [4]arene bearing nalidixic acid as a prodrug [51] J Incl Phenom Macrocycl Chem (2012) 73: 1-15 7 used in the treatment of many diseases including small cell lung, ovarian and cervical cancer. The problem is its low solubility, which have to be prepared as TPT-hydrochloride for improving the solubility.…”

Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents

“…They have also been used in enzyme inhibition and gene transfection studies [44]. Calix[n]arenes have also been used as a non-therapeutic residue in prodrug assemblies [45]. The use of calix[n]arenes as pharmaceutical agents in their own right is not detailed within this review but such compounds do provide opportunities for dual use.…”

Calix[4]arene α-hydroxymethylphosphonic acids as potential inhibitors of protein tyrosine phosphatases

“…Because of their unique three-dimensional structure they have used as important tools for investigations in bioorganic chemistry and medicine [15][16][17][18]. The calixarenes were found to exhibit antibacterial activity against gram-positive and gramnegative bacterial strains [19][20][21], antiviral [22,23] and anticancer properties [24]. Finely, calixarenes can be used for biochemical recognition and separation of bioactive molecules such as amino acids, proteins, nucleotides, saccharides and steroids [25].…”