Towards BirthAlert—A Clinical Device Intended for Early Preterm Birth Detection

Etemadi, Mozziyar; Chung, Philip; Heller, J. Alex; Liu, Jonathan A.; Rand, Larry; Roy, Shuvo

doi:10.1109/tbme.2013.2272601

Cited by 13 publications

(13 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous works published in the literature (Avis et al, 1997;Etemadi et al, 2013;Gandhi et al 2006a;2006b;Hoe et al, 2004;O'Connell et al, 2000) produced results in line with those reported here. However, none of them include an equivalent circuit for the cervical tissue, as it is done here.…”

Section: Discussionsupporting

confidence: 92%

“…2018 June;34(2): 110-114 111/114 disassembles, together with the cervical tissue hydration (Cunningham et al, 2010). Currently, these cervical tissue microstructural changes can be inferred by using two techniques: light-induced fluorescence spectroscopy (LIF) and electrical impedance spectroscopy (EIS) (Etemadi et al, 2013). The former is based on the auto fluorescent properties of the collagen cross-links; and the latter is based on the electrical impedance characteristics of the cervical tissue.…”

Section: Introductionmentioning

confidence: 99%

“…The former is based on the auto fluorescent properties of the collagen cross-links; and the latter is based on the electrical impedance characteristics of the cervical tissue. The use of electrical impedance to assess cervical ripening has been reported in the literature, e.g., Avis et al (1997), Etemadi et al (2013), Gandhi et al (2006a;2006b), Hoe et al (2004) andO'Connell et al (2000). Avis et al (1997) presented in-vitro measurements of the electrical impedance of cervical tissue from samples taken at caesarean sections, and reported differences between term and preterm samples.…”

Section: Introductionmentioning

confidence: 99%

“…In their case, only the larger probe (12 mm) was predictive of any labour. Combined results from LIF and EIS were used in (Etemadi et al, 2013) to assess microstructural changes in the cervix. Initial results were presented for a 6-electrode transvaginal probe.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Preliminary results of cervical impedance measurements

et al. 2018

View full text Add to dashboard Cite

In this work, we report the development and initial tests of a measuring system that is used to measure the cervical electrical impedance with the purpose of assessing cervical ripening. The objective is to offer a system that provides real-time information about the cervical electrical impedance and, indirectly, of the cervical ripening with the aim of preventing premature birth. Methods: Probes were developed and initial tests were performed. The probes used had electrodes that are far apart, with the assumption that in such cases deeper layers of the cervical tissue are measured. Results: Preliminary measurements were performed in a single session on a non-gravid uterus, using as excitation signal a sinusoidal wave with frequency varying from 3 kHz to 100 kHz. Results indicate, as expected, that the magnitude of the impedance is inversely proportional to the frequency, indicating capacitive impedance. Conclusion: Preliminary results were very encouraging. However, further measurements must be performed to correlate the impedance to the cervical ripening.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preliminary results of cervical impedance measurements

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Specific use of this device is described in Etemadi et al 12,13 . The mold used to create the intravaginal probe was fabricated from ABS430 material using a Dimension uPrint Plus 3D printer.…”

Section: Representative Resultsmentioning

confidence: 99%

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Chung

Heller

Etemadi

et al. 2014

JoVE

Self Cite

View full text Add to dashboard Cite

Biologically inert elastomers such as silicone are favorable materials for medical device fabrication, but forming and curing these elastomers using traditional liquid injection molding processes can be an expensive process due to tooling and equipment costs. As a result, it has traditionally been impractical to use liquid injection molding for low-cost, rapid prototyping applications. We have devised a method for rapid and low-cost production of liquid elastomer injection molded devices that utilizes fused deposition modeling 3D printers for mold design and a modified desiccator as an injection system. Low costs and rapid turnaround time in this technique lower the barrier to iteratively designing and prototyping complex elastomer devices. Furthermore, CAD models developed in this process can be later adapted for metal mold tooling design, enabling an easy transition to a traditional injection molding process. We have used this technique to manufacture intravaginal probes involving complex geometries, as well as overmolding over metal parts, using tools commonly available within an academic research laboratory. However, this technique can be easily adapted to create liquid injection molded devices for many other applications.

show abstract

Biomechanics of the human uterus

Myers

Elad

2017

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

The appropriate biomechanical function of the uterus is required for the execution of human reproduction. These functions range from aiding the transport of the embryo to the implantation site, to remodeling its tissue walls to host the placenta, to protecting the fetus during gestation, to contracting forcefully for a safe parturition and postpartum, to remodeling back to its nonpregnant condition to renew the cycle of menstruation. To serve these remarkably diverse functions, the uterus is optimally geared with evolving and contractile muscle and tissue layers that are cued by chemical, hormonal, electrical, and mechanical signals. The relationship between these highly active biological signaling mechanisms and uterine biomechanical function is not completely understood for normal reproductive processes and pathological conditions such as adenomyosis, endometriosis, infertility and preterm labor. Animal studies have illuminated the rich structural function of the uterus, particularly in pregnancy. In humans, medical imaging techniques in ultrasound and magnetic resonance have been combined with computational engineering techniques to characterize the uterus in vivo, and advanced experimental techniques have explored uterine function using ex vivo tissue samples. The collective evidence presented in this review gives an overall perspective on uterine biomechanics related to both its nonpregnant and pregnant function, highlighting open research topics in the field. Additionally, uterine disease and infertility are discussed in the context of tissue injury and repair processes and the role of computational modeling in uncovering etiologies of disease. WIREs Syst Biol Med 2017, 9:e1388. doi: 10.1002/wsbm.1388 For further resources related to this article, please visit the WIREs website.

show abstract

Towards BirthAlert—A Clinical Device Intended for Early Preterm Birth Detection

Cited by 13 publications

References 65 publications

Preliminary results of cervical impedance measurements

Preliminary results of cervical impedance measurements

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Biomechanics of the human uterus

Contact Info

Product

Resources

About