Towards autonomous lateral flow assays: Paper-based microfluidic fuel cell inside an HIV-test using a blood sample as fuel

Déctor, A.; Galindo‐de‐la‐Rosa, J.; Amaya-Cruz, Diana M.; Ortiz‐Verdín, A.; Guerra‒Balcázar, Minerva; Olivares-Ramírez, J.M.; Arriaga, L.G.; Ledesma‐García, J.

doi:10.1016/j.ijhydene.2017.07.079

Cited by 47 publications

(24 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these configurations are based on the integration of hard-electrode materials with a soft nitrocellulose membrane, thus negating the flexible properties of the lateral-flow membranes. To overcome this limitation, Wicaksono et al (Dector et al, 2017) reported the integration of a soft carbon-based working electrode that was placed underneath the nitrocellulose membrane to construct electrochemical lateral-flow tests for melamine in milk sample. In addition, a platinised carbon paper electrode was integrated with a lateral-flow membrane for the construction of electrochemical fuel cells to create selfpowered autonomous lateral flow tests (Esquivel et al, 2014).…”

Section: Lateral-flow Membrane-based Strip Testsmentioning

confidence: 99%

Soft and flexible material-based affinity sensors

Meng

Turner

Mak

2020

Biotechnology Advances

View full text Add to dashboard Cite

Recent advances in biosensors and point-of-care (PoC) devices are poised to change and expand the delivery of diagnostics from conventional lateral-flow assays and test strips that dominate the market currently, to newly emerging wearable and implantable devices that can provide continuous monitoring. Soft and flexible materials are playing a key role in propelling these trends towards real-time and remote health monitoring. Affinity biosensors have the capability to provide for diagnosis and monitoring of cancerous, cardiovascular, infectious and genetic diseases by the detection of biomarkers using affinity interactions. This review tracks the evolution of affinity sensors from conventional lateral-flow assay and test strips to wearable/implantable devices enabled by soft and flexible materials. Initially, we highlight conventional affinity sensors exploiting membrane and paper materials which have been so successfully applied in point-of-care tests, such as lateral-flow immunoassay strips and emerging microfluidic paper-based devices. We then turn our attention to the multifarious polymer designs that provide both the base materials for sensor designs, such as PDMS, and more advanced functionalised materials that are capable of both recognition and transduction, such as conducting and molecularly imprinted polymers. The subsequent content discusses wearable soft and flexible material-based affinity sensors, classified as flexible and skinmountable, textile materials-based and contact lens-based affinity sensors. In the final sections, we explore the possibilities for implantable/injectable soft and flexible affinity sensors, including hydrogels, microencapsulated sensors and optical fibers. This area is truly a work in 2 progress and we trust that this review will help pull together the many technological streams that are contributing to the field.

show abstract

Section: Lateral-flow Membrane-based Strip Testsmentioning

confidence: 99%

Soft and flexible material-based affinity sensors

Meng

Turner

Mak

2020

Biotechnology Advances

View full text Add to dashboard Cite

show abstract

“…Pasala and Ramanujam presented a similar device acting as an ion‐conducting medium with 6 mWcm −2 within 100 minutes . Dector et al demonstrated an MPFC for an HIV test kit using human blood and serum as fuel, which provided a power density of 0.16 mWcm −2 . All these studies indicate that the paper‐based membraneless microfluidic fuel cell, with two inlets driven by colaminar flow and capillary mechanism, has become a significant research domain.…”

Section: Introductionmentioning

confidence: 99%

Performance optimization of microfluidic paper fuel‐cell with varying cellulose fiber papers as absorbent pad

et al. 2020

View full text Add to dashboard Cite

Summary Miniaturization of devices, combined with other features such as portability, proneness to automation, rapid performance, amenability to integration, multiplexing, and cost‐effectiveness, is rapidly increasing for various sensing and energy harvesting applications. One such emerging area is the development of microfluidic fuel cell on cellulose papers, which has enormous scope to optimize its performance. This is primarily because such devices eliminate the need for membranes as well as external pumps since they have built‐in colaminar flow embedded capillaries. Such peripherals are usually used in conventional microfluidic fuel cells, which are fabricated using methods like photolithography, PDMS lithography, and 3D printing. This paper presents investigations on microfluidic paper–based fuel cells (MPFCs) with different cellulose absorbent pads for their performance optimization. Herein, the MPFC utilizes formic acid as fuel, oxygen from quiescent air as oxidant, and sulfuric acid as electrolyte for conducting ionic exchange under colaminar flow. The electrodes are realized through simple pencil strokes depositing a thin layer of graphite. The porous graphite electrodes act as diffusion agents breathing oxygen directly from the atmospheric air. Such an MPFC configuration, costing less than US $1, was optimized to achieve maximum energy density by examining various combinations of absorbent pads with different grades of cellulose papers. It is seen that the maximum open circuit potential is 0.46 V, while the maximum current and power densities are 1505.66 μAcm−2 and 173.97 μWcm−2, respectively, with a grade 6 absorbent pad. Such performance can be further enhanced by investigating MPFCs with various graphite pencils with a diverse number of strokes at different concentration levels.

show abstract

“…Dector et al. presented a paper‐based microfluidic fuel cell inside an HIV‐test kit that runs with blood and serum as the fuel . All these studies indicate paper‐based microfluidic fuel cells specifically with two‐inlet configuration have become the major focus in the realization of membrane‐less fuel cells by introducing co‐laminar nature of the flowing streams necessary to produce energy.…”

Section: Introductionmentioning

confidence: 99%

Selection of Graphite Pencil Grades for the Design of Suitable Electrodes for Stacking Multiple Single‐Inlet Paper‐Pencil Fuel Cells

et al. 2019

View full text Add to dashboard Cite

We present a single-inlet paper-pencil based microfluidic fuel cell which works on the capillary driven fluid flow of a mixture of fuel (formic acid) and electrolyte (dilute sulfuric acid) solutions as a single entity. Different types of pencils are used to prepare the graphite electrodes to observe their effect on the fuel cell performance. The graphite electrodes are porous and act as a gas diffusion electrode which breaths in oxygen directly from the quiescent air and out CO 2 from the cell. The paper fuel cell also fabricated in different dimensions and connected as cell-stacks to enhance its performance. The paper-pencil device generates maximum open circuit potential of ∼ 2.5 V in series combination and maximum current density of ∼ 82 mA cm À 2 and power density of ∼ 100 mW cm À 2 in parallel combination. Later, rGOÀ Cu/CuO nanocomposite embedded electrodes are used to observe their effect on the device performance.[a] Dr.

show abstract

Towards autonomous lateral flow assays: Paper-based microfluidic fuel cell inside an HIV-test using a blood sample as fuel

Cited by 47 publications

References 26 publications

Soft and flexible material-based affinity sensors

Soft and flexible material-based affinity sensors

Performance optimization of microfluidic paper fuel‐cell with varying cellulose fiber papers as absorbent pad

Selection of Graphite Pencil Grades for the Design of Suitable Electrodes for Stacking Multiple Single‐Inlet Paper‐Pencil Fuel Cells

Contact Info

Product

Resources

About