Adaptation to climate change is challenging in terms of managing knowledge flow among diverse actors. This paper examines the roles of key actors in Namibia in the production and dissemination of climate adaptation knowledge. The intention was to identify opportunities for enhancing collaboration among actors to facilitate knowledge flow and uptake in adaptation action. The Omusati Region was used as a case study in understanding the chain of interactions among actors from local/district to the national level vis-à-vis the production and dissemination of adaptation knowledge in Namibia. The researchers conducted key informant interviews with representatives of key organizations in the Namibian adaptation network operating in the Omusati Region. The selection of the organizations of interviewed respondents was based on a previous climate change adaptation stakeholder and influence network mapping exercise in the region. Results indicate that adaptation knowledge generation by organizations happens mainly in the context of other developmental services. Furthermore, most organizations generate their adaptation knowledge internally through their directorates of research and also through cooperation with other organizations. However, there is little or no collaboration between organizations with respect to dissemination of adaptation knowledge to intended targets. The study, therefore, recommends a more concerted effort towards improving collaboration between organizations, and with local communities in the dissemination of adaptation knowledge as a way of enhancing knowledge uptake. This will have practical implications for the improvement in the rate of knowledge uptake in adaptation actions, particularly at the local level. In this regard, the use of workshop and field day meetings show the best prospect for improving collaboration between organizations in knowledge dissemination.