Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice

Tian, Peijun; O’Riordan, Kenneth J.; Lee, Yuan‐Kun; Wang, Gang; Zhao, Jianxin; Zhang, Hao; Cryan, John F.

doi:10.1016/j.ynstr.2020.100216

Cited by 199 publications

(182 citation statements)

References 68 publications

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“…In addition, the remarkable improvement of memory deficits, cerebral neuronal and synaptic injuries, microglia activation, and microbial composition were found in the feces and brain of aged mice model [ 183 ]. Chronically stressed mice treated with B. breve CCFM1025 reversed chronic stress-induced depression and anxiety-like behaviors and gut microbiome changes in vivo [ 184 ]. It has increased the expression of BDNF, SCFAs, and 5-hydroxytryptophan (5-HTP) and decreased the pCREB-c-Fos pathway.…”

Section: Interaction Of Gut and Nervous System: Gut–brain Axismentioning

confidence: 99%

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Suganya

Koo

2020

IJMS

170

112

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The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has the largest and vulnerable surface with desirable features to observe foods, nutrients, and environmental factors, as well as to differentiate commensals, invading pathogens, and others. It is well-known that the gut has a strong connection with the central nervous system (CNS) in the context of health and disease. A healthy gut with diverse microbes is vital for normal brain functions and emotional behaviors. In addition, the CNS controls most aspects of the GI physiology. The molecular interaction between the gut/microbiome and CNS is complex and bidirectional, ensuring the maintenance of gut homeostasis and proper digestion. Besides this, several mechanisms have been proposed, including endocrine, neuronal, toll-like receptor, and metabolites-dependent pathways. Changes in the bidirectional relationship between the GIT and CNS are linked with the pathogenesis of gastrointestinal and neurological disorders; therefore, the microbiota/gut-and-brain axis is an emerging and widely accepted concept. In this review, we summarize the recent findings supporting the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. In addition, we highlight the recent advances in improving of neurological diseases by probiotics/prebiotics/synbiotics and fecal microbiota transplantation via the concept of the gut–brain axis.

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Section: Interaction Of Gut and Nervous System: Gut–brain Axismentioning

confidence: 99%

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Suganya

Koo

2020

IJMS

170

112

View full text Add to dashboard Cite

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“…It also increased the level of 5-hydroxytryptamine and brain-derived neurotrophic factor in the brain and decreased depressive behaviors [ 155 ]. Similarly, other studies using the same probiotics, found that treatment of chronically stressed mice with probiotics could restore gut microbiota perturbation, mitigate inflammation, and alleviate depression- and anxiety-like behaviors [ 156 , 157 ].…”

Section: Effect Of Probiotics On the Gut-brain Axis And Neuroinflamentioning

confidence: 85%

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

et al. 2020

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Inflammation is a biological response to the activation of the immune system by various infectious or non-infectious agents, which may lead to tissue damage and various diseases. Gut commensal bacteria maintain a symbiotic relationship with the host and display a critical function in the homeostasis of the host immune system. Disturbance to the gut microbiota leads to immune dysfunction both locally and at distant sites, which causes inflammatory conditions not only in the intestine but also in the other organs such as lungs and brain, and may induce a disease state. Probiotics are well known to reinforce immunity and counteract inflammation by restoring symbiosis within the gut microbiota. As a result, probiotics protect against various diseases, including respiratory infections and neuroinflammatory disorders. A growing body of research supports the beneficial role of probiotics in lung and mental health through modulating the gut-lung and gut-brain axes. In the current paper, we discuss the potential role of probiotics in the treatment of viral respiratory infections, including the COVID-19 disease, as major public health crisis in 2020, and influenza virus infection, as well as treatment of neurological disorders like multiple sclerosis and other mental illnesses.

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“…Additionally, an increase in the regulation of BDNF was identified. Finally, the authors were also able to conclude that the psychobiotic supplementation managed to restore the equilibrium on the gut microbiota, specifically by the ratio of Actinobacteria to Proteobacteria [ 61 ]. We can observe that Hao, Wang, Guo, and Liu (2019) performed a similar preclinical study whose main objective was to test if Faecalibacterium prausnitzii ATCC 27766 had psychobiotic potential in ameliorating both anxiety and depression symptoms, and whether it could reverse the impact of chronic unpredictable mild stress in rats.…”

Section: Action Mechanisms Regarding the Psychobiotic Potential Ofmentioning

confidence: 99%

Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products

et al. 2020

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The gut-brain-microbiota axis consists of a bilateral communication system that enables gut microbes to interact with the brain, and the latter with the gut. Gut bacteria influence behavior, and both depression and anxiety symptoms are directly associated with alterations in the microbiota. Psychobiotics are defined as probiotics that confer mental health benefits to the host when ingested in a particular quantity through interaction with commensal gut bacteria. The action mechanisms by which bacteria exert their psychobiotic potential has not been completely elucidated. However, it has been found that these bacteria provide their benefits mostly through the hypothalamic-pituitary-adrenal (HPA) axis, the immune response and inflammation, and through the production of neurohormones and neurotransmitters. This review aims to explore the different approaches to evaluate the psychobiotic potential of several bacterial strains and fermented products. The reviewed literature suggests that the consumption of psychobiotics could be considered as a viable option to both look after and restore mental health, without undesired secondary effects, and presenting a lower risk of allergies and less dependence compared to psychotropic drugs.

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Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice

Cited by 199 publications

References 68 publications

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products

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