2017
DOI: 10.1016/j.ecolind.2017.03.038
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Towards a physiological response of fishes under variable environmental conditions: An approach through neural network

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Cited by 18 publications
(4 citation statements)
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“…Therefore, impacts of environmental variables (such as temperature and pH) and growth dilution on ADME processes of chemicals in fish species are assumed crucial. 12 Besides, unlike human PBTK models, obvious interspecific variation in sensitivity across various fish species cannot be ignored, which may significantly influence the reliability of chemical ecological risk assessment results. 13 Despite the increasing development of fish PBTK models, some critical issues in construction and validation of models still exist: (1) many models were oversimplified without involving the main biological pathways and target tissues of chemicals.…”
Section: Introductionmentioning
confidence: 99%
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“…Therefore, impacts of environmental variables (such as temperature and pH) and growth dilution on ADME processes of chemicals in fish species are assumed crucial. 12 Besides, unlike human PBTK models, obvious interspecific variation in sensitivity across various fish species cannot be ignored, which may significantly influence the reliability of chemical ecological risk assessment results. 13 Despite the increasing development of fish PBTK models, some critical issues in construction and validation of models still exist: (1) many models were oversimplified without involving the main biological pathways and target tissues of chemicals.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, fish physiological properties can also be altered by complicated environmental conditions. Therefore, impacts of environmental variables (such as temperature and pH) and growth dilution on ADME processes of chemicals in fish species are assumed crucial . Besides, unlike human PBTK models, obvious interspecific variation in sensitivity across various fish species cannot be ignored, which may significantly influence the reliability of chemical ecological risk assessment results …”
Section: Introductionmentioning
confidence: 99%
“…The large volume of contaminants in the aquatic ecosystem, may induce oxidative stress on the biota including fish, causing temporary or permanent damage in oxidative homeostasis and imbalance of metabolic pathways (12,14). Biomarkers including antioxidant defence enzymes have been used immensely to provide the link between external concentrations of contaminant exposure, internal concentrations of contaminant in tissue and early adverse effects in organism (15,16,17), as such provide critical information on ecosystem structure and function (5).…”
Section: Introductionmentioning
confidence: 99%
“…Silver coloured African Catfish Chrysichthys nigrodigitatus (Lacepede 1802) is a commercial fish of high value among indigenous African populations (21). It is a benthopelagic fish, whose diet components includes sand particles, phytoplankton, zooplanktons and macrobenthic organisms (22,23). This fish inhabits the lagoon, and its feeding habits predisposes it to metal accumulation, hence there is a possibility that contaminants in the lagoon may exert stress, induce oxidative damage to physiological processes and ultimately affect the wild population.…”
Section: Introductionmentioning
confidence: 99%