1988
DOI: 10.1016/0264-410x(88)90134-x
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Towards a live oral vaccine against enterotoxigenic Escherichia coli of swine

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Cited by 24 publications
(11 citation statements)
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“…Heterologous Ag delivery by Salmonella used to be largely dependent upon antibiotic selectable genes (37,38) or by alternative methods, including nonantibiotic-based vectors (39), balanced lethal stabilization systems (20,40), or by chromosomal insertions (41,42). Owing to the apparent drawbacks of stability and antibiotic gene leakage, the antibiotic-based vector delivery systems cannot be further developed for human use.…”
Section: Discussionmentioning
confidence: 99%
“…Heterologous Ag delivery by Salmonella used to be largely dependent upon antibiotic selectable genes (37,38) or by alternative methods, including nonantibiotic-based vectors (39), balanced lethal stabilization systems (20,40), or by chromosomal insertions (41,42). Owing to the apparent drawbacks of stability and antibiotic gene leakage, the antibiotic-based vector delivery systems cannot be further developed for human use.…”
Section: Discussionmentioning
confidence: 99%
“…Since the initial proposal to use Salmonella organisms to deliver fimbrial antigens (3,31,42,50), construction of such recombinants that stably express high levels of CFA/I, K88, and K99 fimbriae has evolved from the utilization of antibioticbased vectors (3,50) and nonantibiotic-based vectors (for plasmid retention and antigen expression) (4,42) to the present well-established balanced lethal stabilization system in Salmonella (17,36,48). Here we report the construction of a bal- FIG.…”
Section: Discussionmentioning
confidence: 99%
“…ETEC virulence is also dependent on the expression of fimbrial colonization factor antigens, which mediate the colonization of the gastrointestinal tract (25,26,30). This heterogeneous group of fimbrial adhesins also dictates host specificity (1,3,25,26), and antibodies against these fimbriae have been implicated in protective immunity against ETEC infection in a number of animal and human systems (1,15,25,26,30,32).…”
mentioning
confidence: 99%
“…Live oral vaccines still represent a more controlled and more effective way of specific immune prevention of neonatal diarrhoea as compared to the so-called "feed back" (feeding of diarrhoeal faecal material to pregnant sows, as practised on some farms). The use of recombinant Salmonella-vector vaccines expressing the necessary adhesive epitopes could also come into question (Attridge et al, 1988;Morona et al, 1994). Finally, it is hoped that more progress in the area of genetically engineered plants (containing the required antigens produced for feeding) will be made in the future.…”
Section: Prevention By Vaccination (Using Adhesins As Protective Antimentioning
confidence: 99%