Towards a classification strategy for complex nanostructures

Castagnola, Valentina; Cookman, Jennifer; Araújo, João M. de; Polo, Ester; Cai, Qi; Silveira, Camila P.; Krpetić, Željka; Yan, Yan; Boselli, Luca; Dawson, Kenneth A.

doi:10.1039/c6nh00219f

Cited by 45 publications

(27 citation statements)

References 88 publications

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“…Their agglomeration state depends on their electromagnetic properties, such as surface charge and magnetism [78]. When in a liquid, their agglomeration depends on their surface morphology and functionalization which can confer them either hydrophobicity or hydrophilicity [79,80], see Figure 3A. Nanoparticles can be made of a single material, compact or hollow.…”

Section: Classificationmentioning

confidence: 99%

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Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

2019

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The interaction of drugs with DNA has been searched thoroughly giving rise to an endless number of findings of undoubted importance, such as a prompt alert to harmful substances, ability to explain most of the biological mechanisms, or provision of important clues in targeted development of novel chemotherapeutics. The existence of some drugs that induce oxidative damage is an increasing point of concern as they can cause cellular death, aging, and are closely related to the development of many diseases. Because of a direct correlation between the response, strength/ nature of the interaction and the pharmaceutical action of DNA‐targeted drugs, the electrochemical analysis is based on the signals of DNA before and after the interaction with the DNA‐targeted drug. Nowadays, nanoscale materials are used extensively for offering fascinating characteristics that can be used in designing new strategies for drug‐DNA interaction detection. This work presents a review of nanomaterials (NMs) for the study of drug‐nucleic acid interaction. We summarize types of drug‐DNA interactions, electroanalytical techniques for evidencing these interactions and quantification of drug and/or DNA monitoring.

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Section: Classificationmentioning

confidence: 99%

“…A. The multitude of possibilities in terms of the combination of physical properties, surface chemistry, and functionalization which will be further modified by the biological environment From references[79] with permission from The Royal Society of Chemistry. B.…”

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confidence: 99%

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

2019

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“…This can modify both the surface charge and the superficial chemistry of the nanoparticle. Another common effect is the increase in particle size, which in turns affects stability, modifies NPs‐cell interactions and biodistribution ,,. Protein type and composition of the biological environment, exposition time, and physicochemical factors can also alter the size of the protein corona …”

Section: Action Mechanisms In Vivomentioning

confidence: 99%

“…Another common effect is the increase in particle size, which in turns affects stability, modifies NPs-cell interactions and biodistribution. [52,229,230] Protein type and composition of the biological environment, exposition time, and physicochemical factors can also alter the size of the protein corona. [231] The size and shape of a particle are key factors that determine its surface free energy, in turn affecting protein adsorption; for this reason, morphology control is very 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 important.…”

Section: Protein Coronamentioning

confidence: 99%

Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

et al. 2018

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To achieve optimal results when employing nanoparticles in biomedical fields, choosing the right type of nanoparticle and determining the correct procedure for drug loading are key factors. Each type of nanoparticle presents a determined set of characteristics that are, in some cases, unique. In general, their surface charge, geometry or hydrophilic character may be limiting factors, depending on what their intended application is. Once synthesized, additional factors, such as their interaction with biological systems and liberation mechanisms into the target cells, also need to be taken into account. Multiple advantages arise from the use of nanoparticles, such as the capability to solubilize hydrophobic compounds and an increased bioavailability. Those advantages justify the extensive and delicate study that should be undertaken in order to use them as drug delivery agents. One of the most important factors for the design of a drug delivery system with nanoparticles is achieving a high drug-to-nanoparticle ratio. In this Minireview, all of these key factors, both physicochemical and biological, are described, and special emphasis is placed on loading methods employed to introduce drugs into nanoparticles.

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“…[5][6][7][8][9][10] It is also now believed that more complex forms of receptor-corona engagements involving scavenger and pattern recognition interactions are relevant. 11 In parallel, shape, on the nanoscale, is being investigated as a defining factor in framing biological interactions, [12][13][14][15] and therefore it can be hypothesized that this combination of shape and surface biomolecular presentation could form the basis of a broader view of biological recognition.…”

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confidence: 99%

Graphene Nanoflake Uptake Mediated by Scavenger Receptors

et al. 2019

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The biological interactions of graphene have been extensively investigated over the last 10 years. However, very little is known about graphene interactions with the cell surface and how the graphene internalization process is driven and mediated by specific recognition sites at the interface with the cell. In this work, we propose a methodology to investigate direct molecular correlations between the biomolecular corona of graphene and specific cell receptors, showing that key protein recognition motifs, presented on the nanomaterial surface, can engage selectively with specific cell-receptors. We consider the case of apolipoprotein A-I, found to be very abundant in the graphene protein corona, and observe that the uptake of graphene nanoflakes is somewhat increased in cells with greatly elevated expression of scavenger receptors B1, suggesting a possible mechanism of endogenous interaction. The uptake results, obtained by flow cytometry, have been confirmed using Raman microspectroscopic mapping, exploiting the strong Raman signature of graphene.

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Towards a classification strategy for complex nanostructures

Abstract: The range of possible nanostructures is so large and continuously growing, that collating and unifying the knowledge connected to them, including their biological activity, is a major challenge.

Cited by 45 publications

References 88 publications

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

Graphene Nanoflake Uptake Mediated by Scavenger Receptors

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