Toward portable breath acetone analysis for diabetes detection

Righettoni, Marco; Tricoli, Antonio

doi:10.1088/1752-7155/5/3/037109

Cited by 121 publications

(88 citation statements)

References 48 publications

(83 reference statements)

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“…2 The current breathe analysers are based on gas chromatography and mass spectrometry, which are large, expensive, and require pre-concentration procedures for reliable measurement. 6 Metal oxide based chemo-resistive sensors has shown significant potential because of their high sensitivity towards different analytes with fast response and recovery. 6 Metal oxide based chemo-resistive sensors has shown significant potential because of their high sensitivity towards different analytes with fast response and recovery.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical nanostructured WO₃–SnO₂for selective sensing of volatile organic compounds

et al. 2015

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It remains a challenge to find a suitable gas sensing material that shows a high response and shows selectivity towards various gases simultaneously. Here, we report a mixed metal oxide WO3-SnO2 nanostructured material synthesized in situ by a simple, single-step, one-pot hydrothermal method at 200 °C in 12 h, and demonstrate its superior sensing behavior towards volatile organic compounds (VOCs) such as ammonia, ethanol and acetone. SnO2 nanoparticles with controlled size and density were uniformly grown on WO3 nanoplates by varying the tin precursor. The density of the SnO2 nanoparticles on the WO3 nanoplates plays a crucial role in the VOC selectivity. The responses of the present mixed metal oxides are found to be much higher than the previously reported results based on single/mixed oxides and noble metal-doped oxides. In addition, the VOC selectivity is found to be highly temperature-dependent, with optimum performance obtained at 200 °C, 300 °C and 350 °C for ammonia, ethanol and acetone, respectively. The present results on the cost-effective noble metal-free WO3-SnO2 sensor could find potential application in human breath analysis by non-invasive detection.

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Section: Introductionmentioning

confidence: 99%

Hierarchical nanostructured WO₃–SnO₂for selective sensing of volatile organic compounds

et al. 2015

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“…Furthermore, there are robust and portable prototypes that show the possibility of miniaturization in the coming decades. 6 Due to its potential, the development of exhaled breath analysis is reaching technological and commercial importance. 7 In particular, acetone is a very attractive molecule to study diabetes because its volatility makes it easy to detect in breath.…”

mentioning

confidence: 99%

Study of the Exhaled Acetone in Type 1 Diabetes Using Quantum Cascade Laser Spectroscopy

et al. 2014

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The acetone concentration exhaled in the breath of three type 1 diabetes patients (two minors and one adult) and one healthy volunteer is studied using a quantum cascade laser-based spectroscopic system. Using the acetone signature between 1150 and 1250 cm(-1) and a multiline fitting method, the concentration variations on the order of parts per billion by volume were measured. Blood glucose and ketone concentrations in blood measurements were performed simultaneously to study their relation with acetone in exhaled breath. We focus on personalized studies to better understand the role of acetone in diabetes. For each volunteer, we performed a series of measurements over a period of time, including overnight fastings of 11 ± 1 h and during ketosis-hyperglycemia events for the minors. Our results highlight the importance of performing personalized studies because the response of the minors to the presence of ketosis was consistent but unique for each individual. Also, our results emphasize the need for performing more studies with T1D minors, because the acetone concentration in the breath of the minors differs, with respect to those reported in the literature, which are based on adults.

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“…A correlation between acetone concentration in exhaled breath and blood glucose concentration has also been reported (Righettoni et al 2013). The acetone concentration of exhaled breath in healthy people ranges from 200 to 900 ppb in previous research (Righettoni and Tricoli 2011;Toyooka et al 2013). Increases in breath acetone concentration are usually a sign that cells lack insulin or are unable to effectively use available insulin; this occurs in diabetes.…”

mentioning

confidence: 71%

An acetone bio-sniffer (gas phase biosensor) enabling assessment of lipid metabolism from exhaled breath

Chien

Toma

et al. 2015

Biosensors and Bioelectronics

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Several volatile organic compounds (VOCs) are released from human breath or skin. Like chemical substances in blood or urine, some of these vapors can provide valuable information regarding the state of the human body. A highly sensitive acetone biochemical gas sensor (bio-sniffer) was developed and used to measure exhaled breath acetone concentration, and assess lipid metabolism based on breath acetone analysis. A fiber-optic biochemical gas sensing system was constructed by attaching a flow-cell with nicotinamide adenine dinucleotide (NADH)-dependent secondary alcohol dehydrogenase (S-ADH) immobilized membrane onto a fiber-optic NADH measurement system. The NADH measurement system utilizes an ultraviolet-light emitting diode with peak emission of 335 nm as an excitation light source. NADH is consumed by the enzymatic reaction of S-ADH, and the consumption is proportional to the concentration of acetone vapor. Phosphate buffer which contained NADH was circulated into the flow-cell to rinse products and the excessive substrates from the optode. The change of fluorescent emitted from NADH is analyzed by the PMT. Hence, fluorescence intensity decreased as the acetone concentration increased. The relationship between fluorescence intensity and acetone concentration was identified from 20 ppb to 5300 ppb. This interval included the concentration of acetone vapor in the breath of healthy people and those suffering from disorders of carbohydrate metabolism. Finally, the acetone bio-sniffer was used to measure breath acetone during an exercise stress test on an ergometer after a period of fasting. The concentration of acetone in breath was shown to significantly increase after exercise. This biosensor allows rapid, highly sensitive and selective measurement of lipid metabolism.

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Toward portable breath acetone analysis for diabetes detection

Cited by 121 publications

References 48 publications

Hierarchical nanostructured WO₃–SnO₂for selective sensing of volatile organic compounds

Hierarchical nanostructured WO₃–SnO₂for selective sensing of volatile organic compounds

Study of the Exhaled Acetone in Type 1 Diabetes Using Quantum Cascade Laser Spectroscopy

An acetone bio-sniffer (gas phase biosensor) enabling assessment of lipid metabolism from exhaled breath

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Toward portable breath acetone analysis for diabetes detection

Cited by 121 publications

References 48 publications

Hierarchical nanostructured WO3–SnO2for selective sensing of volatile organic compounds

Hierarchical nanostructured WO3–SnO2for selective sensing of volatile organic compounds

Study of the Exhaled Acetone in Type 1 Diabetes Using Quantum Cascade Laser Spectroscopy

An acetone bio-sniffer (gas phase biosensor) enabling assessment of lipid metabolism from exhaled breath

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Product

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Hierarchical nanostructured WO₃–SnO₂for selective sensing of volatile organic compounds

Hierarchical nanostructured WO₃–SnO₂for selective sensing of volatile organic compounds