Toward a Practical Impedimetric Biosensor: A Micro-Gap Parallel Plate Electrode Structure That Suppresses Unexpected Device-to-Device Variations

Honda, Haruka; Kusaka, Yusuke; Wu, Haiyun; Endo, Hideki; Tsuya, Daiju; Ohnuki, Hitoshi

doi:10.1021/acsomega.1c06942

Cited by 6 publications

(3 citation statements)

References 46 publications

(67 reference statements)

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“…The use of an alternative redox couple for an impedimetric biosensor with high stability was proposed for a stable IgG biosensor with redox-probe Hexaammineruthenium (II)/(III) [ 87 ]. Protein G has a binding affinity with IgG, so this interaction of both proteins was used to develop a highly sensitive biosensor with a limit of detection up to 1 × 10 –14 mol/L [ 41 ]. Moreover, measles-specific primary IgG antibodies have been reported to be sensed via an impedimetric immunosensor with the help of a label-free approach [ 42 ].…”

Section: Biosensors For the Detection Of Iggmentioning

confidence: 99%

Emerging Methods in Biosensing of Immunoglobin G—A Review

Azam

Bukhari

Liaqat

et al. 2023

Sensors

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Human antibodies are produced due to the activation of immune system components upon exposure to an external agent or antigen. Human antibody G, or immunoglobin G (IgG), accounts for 75% of total serum antibody content. IgG controls several infections by eradicating disease-causing pathogens from the body through complementary interactions with toxins. Additionally, IgG is an important diagnostic tool for certain pathological conditions, such as autoimmune hepatitis, hepatitis B virus (HBV), chickenpox and MMR (measles, mumps, and rubella), and coronavirus-induced disease 19 (COVID-19). As an important biomarker, IgG has sparked interest in conducting research to produce robust, sensitive, selective, and economical biosensors for its detection. To date, researchers have used different strategies and explored various materials from macro- to nanoscale to be used in IgG biosensing. In this review, emerging biosensors for IgG detection have been reviewed along with their detection limits, especially electrochemical biosensors that, when coupled with nanomaterials, can help to achieve the characteristics of a reliable IgG biosensor. Furthermore, this review can assist scientists in developing strategies for future research not only for IgG biosensors but also for the development of other biosensing systems for diverse targets.

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Section: Biosensors For the Detection Of Iggmentioning

confidence: 99%

Emerging Methods in Biosensing of Immunoglobin G—A Review

Azam

Bukhari

Liaqat

et al. 2023

Sensors

View full text Add to dashboard Cite

show abstract

“…The electrical sensors employed several transducing methods such as amperometry, potentiometry, impedimetry, calorimetry, chromatography, and mass-balance detection. ,,− Electrical tests are favorable in many circumstances because they can be easily integrated with a smartphone readout and because of the ability to share data wirelessly with the primary care doctor or store it in the Cloud for future use.…”

Section: Diagnostic Tests Of Sars-cov-2 Based On Nanomaterials and 2d...mentioning

confidence: 99%

Diagnostic Approaches For COVID-19: Lessons Learned and the Path Forward

Alafeef

Pan

2022

ACS Nano

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Coronavirus disease 2019 (COVID-19) is a transmitted respiratory disease caused by the infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although humankind has experienced several outbreaks of infectious diseases, the COVID-19 pandemic has the highest rate of infection and has had high levels of social and economic repercussions. The current COVID-19 pandemic has highlighted the limitations of existing virological tests, which have failed to be adopted at a rate to properly slow the rapid spread of SARS-CoV-2. Pandemic preparedness has developed as a focus of many governments around the world in the event of a future outbreak. Despite the largely widespread availability of vaccines, the importance of testing has not diminished to monitor the evolution of the virus and the resulting stages of the pandemic. Therefore, developing diagnostic technology that serves as a line of defense has become imperative. In particular, that test should satisfy three criteria to be widely adopted: simplicity, economic feasibility, and accessibility. At the heart of it all, it must enable early diagnosis in the course of infection to reduce spread. However, diagnostic manufacturers need guidance on the optimal characteristics of a virological test to ensure pandemic preparedness and to aid in the effective treatment of viral infections. Nanomaterials are a decisive element in developing COVID-19 diagnostic kits as well as a key contributor to enhance the performance of existing tests. Our objective is to develop a profile of the criteria that should be available in a platform as the target product. In this work, virus detection tests were evaluated from the perspective of the COVID-19 pandemic, and then we generalized the requirements to develop a target product profile for a platform for virus detection.

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“…Thus, device-to-device variation needs to be suppressed, which requires rigorous simulations and calculations for guiding innovative fabrication techniques. Honda et al thus fabricated a practical impediment biosensor having parallel plate electrodes (PPE) with an insulated electrode edge that enables current to be uniformly distributed on a planar electrode surface [ 97 ]. This improved the device-to-device variation as compared to interdigitated microelectrode (IDE) arrays.…”

Section: Challenges In Device Yield and Device-to-device Variationmentioning

confidence: 99%

Advancement and Challenges of Biosensing Using Field Effect Transistors

Thriveni

Ghosh

2022

Biosensors

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Field-effect transistors (FETs) have become eminent electronic devices for biosensing applications owing to their high sensitivity, faster response and availability of advanced fabrication techniques for their production. The device physics of this sensor is now well understood due to the emergence of several numerical modelling and simulation papers over the years. The pace of advancement along with the knowhow of theoretical concepts proved to be highly effective in detecting deadly pathogens, especially the SARS-CoV-2 spike protein of the coronavirus with the onset of the (coronavirus disease of 2019) COVID-19 pandemic. However, the advancement in the sensing system is also accompanied by various hurdles that degrade the performance. In this review, we have explored all these challenges and how these are tackled with innovative approaches, techniques and device modifications that have also raised the detection sensitivity and specificity. The functional materials of the device are also structurally modified towards improving the surface area and minimizing power dissipation for developing miniaturized microarrays applicable in ultra large scale integration (ULSI) technology. Several theoretical models and simulations have also been carried out in this domain which have given a deeper insight on the electron transport mechanism in these devices and provided the direction for optimizing performance.

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Toward a Practical Impedimetric Biosensor: A Micro-Gap Parallel Plate Electrode Structure That Suppresses Unexpected Device-to-Device Variations

Cited by 6 publications

References 46 publications

Emerging Methods in Biosensing of Immunoglobin G—A Review

Emerging Methods in Biosensing of Immunoglobin G—A Review

Diagnostic Approaches For COVID-19: Lessons Learned and the Path Forward

Advancement and Challenges of Biosensing Using Field Effect Transistors

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